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Role of Medicinal Plants in Pulmonary Hypertension

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Medicinal Plants for Lung Diseases

Abstract

Pulmonary hypertension is a chronic and advanced disease associated with increased resistance to the pulmonary vasculature, which causes changes in the morphology of the pulmonary arteries and is a major reason for death worldwide. It is associated more in women than in men. It remains asymptomatic until the harmful effects of hypertension such as stroke, myocardial infarction, etc. are observed. Synthetic drugs are used to overcome this disease, but they produce serious side effects, so alternative medicines from medicinal plants need to be developed. Traditionally, medicinal plants have been used since ancient time and are shown to be effective. Examples of plants include Moringa Oleifera Lam, Allium sativum L., Terminalia Arjuna, Withania Somnifera, and many more. They act by decreasing SOD, increasing nitric oxide levels, and also lowering the BCL2/BAX ratio. This chapter focuses on the recent discovery of medicinal plants and its phytoconstituents used in the treatment of pulmonary hypertension and the pathways involved.

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Conflicts of Interest

The authors declare no conflict of interest.

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Author notes

  1. Deepak Kumar Jindal and Prachi Sah contributed equally.

Authors and Affiliations

  1. Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology, Hisar, Haryana, India

    Deepak Kumar Jindal

  2. Department of Pharmaceutical Sciences, Sardar Bhagwan Singh University, Dehradun, Uttarakhand, India

    Prachi Sah

  3. Department of Pharmaceutical Sciences, Kumaun University, Nainital, Uttarakhand, India

    Dheeraj Bisht

  4. Department of Pharmacy, Regional Institute of Paramedical and Nursing Sciences, Aizawl, Mizoram, India

    H. Lalhlenmawia

  5. Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, UCSI University, Kuala Lumpur, Malaysia

    Dharmendra Kumar

  6. Department of Pharmaceutical Chemistry, School of Pharmaceutical Sciences, Shoolini University, Solan, Himachal Pradesh, India

    Deepak Kumar

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  1. Deepak Kumar Jindal
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  2. Prachi Sah
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Editor information

Editors and Affiliations

  1. Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Sydney, NSW, Australia

    Kamal Dua

  2. Discipline of Medical Sciences, School of Science, Western Sydney University, Sydney, NSW, Australia

    Srinivas Nammi

  3. NICM Health Research Institute, Western Sydney University, Sydney, NSW, Australia

    Dennis Chang

  4. Department of Life Sciences, School of Pharmacy, International Medical University, Kuala Lumpur, Malaysia

    Dinesh Kumar Chellappan

  5. School of Pharmacy, Suresh Gyan Vihar University, Jaipur, Rajasthan, India

    Gaurav Gupta

  6. Faculty of Health, Queensland University of Technology, Brisbane, QLD, Australia

    Trudi Collet

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Jindal, D.K., Sah, P., Bisht, D., Lalhlenmawia, H., Kumar, D., Kumar, D. (2021). Role of Medicinal Plants in Pulmonary Hypertension. In: Dua, K., Nammi, S., Chang, D., Chellappan, D.K., Gupta, G., Collet, T. (eds) Medicinal Plants for Lung Diseases. Springer, Singapore. https://doi.org/10.1007/978-981-33-6850-7_13

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