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Application of Indocyanine Green Fluorescent Imaging in Biliary Surgery

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Biliary Tract Surgery
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Abstract

Molecular imaging (MI) is a comprehensive interdisciplinary subject that is the product of the combination of medical imaging technology and modern molecular biology. It involves the qualitative and quantitative study of organisms in vivo at the cellular and molecular levels through imaging technology and methods. Through MI, various pathophysiological processes in the body at the cellular or subcellular levels can be reflected and identified. Compared with the current clinical imaging studies of the human form from the morphological and structural aspects, molecular imaging focuses on revealing the occurrence and development process of diseases at the biochemical and intracellular pathways. Optical imaging, as an essential component and living force of molecular imaging, combines high sensitivity with no ionizing radiation. It can detect the optical signals emitted by endogenous or exogenous contrast agents and present to the observer the coding information of the biochemistry process in vivo carried by the signal.

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References

  • AbbasoÄŸlu O, Tekant Y, Alper A, et al. Prevention and acute management of biliary injuries during laparoscopic cholecystectomy: Expert consensus statement. Ulus Cerrahi Derg. 2016;32(4):300–5.

    Google Scholar 

  • Aoki T, Yasuda D, Shimizu Y, et al. Image-guided liver mapping using fluorescence navigation system with indocyanine green for anatomical hepatic resection. World J Surg. 2008;32:1763–7. https://doi.org/10.1007/s00268-008-9620-y.

    Article  PubMed  Google Scholar 

  • Capussotti L, Ferrero A, Vigano L, Sgotto E, Muratore A, Polastri R. Bile leakage and liver resection: where is the risk? Arch Surg. 2006;141:690–4.

    Article  Google Scholar 

  • Caro JJ, Trindade E, McGregor M. The risks of death and of severe nonfatal reactions with high- vs low-osmolality contrast media: a metanalysis. AJR Am J Roentgenol. 1991;156:825–32.

    Article  CAS  Google Scholar 

  • Dip FD, Asbun D, Rosales-Velderrain A, et al. Cost analysis and effectiveness comparing the routine use of intraoperative fluorescent cholangiography with fluoroscopic cholangiogram in patients undergoing laparoscopic cholecystectomy. Surg Endosc. 2014;28(6):1838–43.

    Article  Google Scholar 

  • Flum DR, Dellinger EP, Cheadle A, Chan L, Koepsell T. Intraoperative cholangiography and risk of common bile duct injury during cholecystectomy. JAMA. 2003;289(13):1639–44. https://doi.org/10.1001/jama.289.13.1639.

    Article  PubMed  Google Scholar 

  • Ishizawa T, Fukushima N, Shibahara J, et al. Real-time identification of liver cancers by using indocyanine green fluorescent imaging[J]. Cancer. 2009;115(11):2491–504.

    Article  Google Scholar 

  • Jonak C, Skvara H, Kunstfeld R, Trautinger F, Schmid JA. Intradermal indocyanine green for in vivo fluorescence laser scanning microscopy of human skin: a pilot study. PLoS One. 2011;6(8):e23972. https://doi.org/10.1371/journal.pone.0023972.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Landsman ML, Kwant G, Mook GA, et al. Light-absorbing properties, stability, and spectral stabilization of indocyanine green. J Appl Physiol. 1976;40:575–83. https://doi.org/10.1152/jappl.1976.40.4.575.

    Article  CAS  PubMed  Google Scholar 

  • Lieberman PL, Seigle RL. Reactions to radiocontrast material: anaphylactoid events in radiology. Clin Rev Allergy Immunol. 1999;17:469–96.

    Article  CAS  Google Scholar 

  • Morita Y, Sakaguchi T, Unno N, et al. Detection of hepatocellular carcinomas with near-infrared fluorescence imaging using indocyanine green: its usefulness and limitation. Int J Clin Oncol. 2013;18:232–41. https://doi.org/10.1007/s10147-011-0367-3.

    Article  CAS  PubMed  Google Scholar 

  • Nishino H, Hatano E, Seo S, et al. Real-time navigation for liver surgery using projection mapping with indocyanine green fluorescence: development of the novel medical imaging projection system. Ann Surg. 2018;267(6):1134–40.

    Article  Google Scholar 

  • Osayi SN, Wendling MR, Drosdeck JM, Chaudhry UI, Perry KA, Noria SF, Mikami DJ, Needleman BJ, Muscarella P II, Abdel-Rasoul M, et al. Near-infrared fluorescent cholangiography facilitates identification of biliary anatomy during laparoscopic cholecystectomy. Surg Endosc. 2015;29(2):368–75.

    Article  Google Scholar 

  • Pesce A, Piccolo G, La Greca G, Puleo S. Utility of fluorescent cholangiography during laparoscopic cholecystectomy: a systematic review. World J Gastroenterol. 2015;21(25):7877–83. https://doi.org/10.3748/wjg.v21.i25.7877.

    Article  PubMed  PubMed Central  Google Scholar 

  • Sanjay P, Tagolao S, Dirkzwager I, Bartlett A. A survey of the accuracy of interpretation of intraoperative cholangiograms. HPB (Oxford). 2012;14(10):673–6. https://doi.org/10.1111/j.1477-2574.2012.00501.x.

    Article  Google Scholar 

  • Tanaka S, Hirohashi K, Tanaka H, Shuto T, Lee SH, Kubo S, Takemura S, Yamamoto T, Uenishi T, Kinoshita H. Incidence and management of bile leakage after hepatic resection for malignant hepatic tumors. J Am Coll Surg. 2002;195:484–9.

    Article  Google Scholar 

  • Trcka J, Schmidt C, Seitz CS, Bröcker E-B, Gross GE, Trautmann A. Anaphylaxis to iodinated contrast material: nonallergic hypersensitivity or IgE-mediated allergy? AJR Am J Roentgenol. 2008;190:666–70.

    Article  Google Scholar 

  • Way LW, Stewart L, Gantert W, Liu K, Lee CM, Whang K, Hunter JG. Causes and prevention of laparoscopic bile duct injuries: analysis of 252 cases from a human factors and cognitive psychology perspective. Ann Surg. 2003;237:460–9.

    PubMed  PubMed Central  Google Scholar 

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Fang, C., Zhu, W. (2021). Application of Indocyanine Green Fluorescent Imaging in Biliary Surgery. In: Fang, C., Lau, W.Y. (eds) Biliary Tract Surgery. Springer, Singapore. https://doi.org/10.1007/978-981-33-6769-2_7

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  • DOI: https://doi.org/10.1007/978-981-33-6769-2_7

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  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-33-6768-5

  • Online ISBN: 978-981-33-6769-2

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