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A Non-human Primate Model for Cerebral Stroke

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Models and Techniques in Stroke Biology

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Abstract

Rodents have extensively used in the production of ischemic stroke. However, effective therapeutical treatments have been tested in the rodent stroke model and have often been ineffective when tested clinically. Subsequently, to close the gap between human and rodent studies, the panel of the Academic Stroke Therapy Committee (STAIR) recommends using non-human primates (NHP) for translational stroke and pre-clinical research. NHP is similar to the human brain through brain metabolism, white/gray matter ratio, cerebrovascular system, and abundant behavioral capabilities. Most ischemic strokes are ephemeral and permanent middle cerebral artery (MCA) occlusion foremost to stroke due to an embolic or filamentous method. This chapter will provide a summary of the transient and permanent occlusion of the MCA in the NHP. The advantage, disadvantages, and potential applications shall be examined for each model. The NHP model of transient focal cerebral ischemia offers excellent opportunities to understand the cellular and vascular pathophysiology of ischemic brain injury that mimics human stroke and the suitable model for pharmacological interventions in relevant human contexts.

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Abbreviations

NHP:

Non human primate

MCA:

Middle cerebral artery occlusion

rtPA:

Recombinant tissue plasminogen artery

STAIR:

Stroke therapy academic industry roundtable

MCAO:

Middle cerebral artery occlusion

RCBF:

Regional cerebral blood flow

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Authors and Affiliations

  1. Amity Institute of Biotechnology, Amity University Mumbai, Mumbai, India

    Jovel Varghese Jose

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  1. Jovel Varghese Jose
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Editors and Affiliations

  1. School of Biomedical Engineering, Indian Institute of Technology BHU, Varanasi, Uttar Pradesh, India

    Amit Kumar Tripathi

  2. Amity Institute of Neuropsychology and Neurosciences, Amity University, Noida, Uttar Pradesh, India

    Abhishek Kumar Singh

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Jose, J.V. (2021). A Non-human Primate Model for Cerebral Stroke. In: Tripathi, A.K., Singh, A.K. (eds) Models and Techniques in Stroke Biology . Springer, Singapore. https://doi.org/10.1007/978-981-33-6679-4_4

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