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Dopamine in the Pancreas

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Dopamine in the Gut

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Abstract

Dopamine (DA) presents in the pancreas at a high level. Pancreatic endocrine or exocrine is able to synthesize DA, although DA may come from other sources such as the autonomic nervous system and blood circulation. Dopamine receptors (DARs), including D1R, D2R, D3R, D4R, and D5R, are widely expressed in the pancreatic tissues. Pancreatic DA regulates insulin secretion and protects pancreas from inflammation. DA-related biomarkers such as the vesicular monoamine transporter 2 (VMAT2) and D2R have become the research hot spots to look for the therapeutic targets and develop the pancreatic islets imaging probes used for monitoring β-cell mass morphology and physiology.

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Abbreviations

6-OHDA:

6-hydroxydopamine

COMT:

Catechol-O-methyltransferase

D1R:

Dopamine D1 receptor

D2R:

Dopamine D2 receptor

D3R:

Dopamine D3 receptor

D4R:

Dopamine D4 receptor

D5R:

Dopamine D5 receptor

DA:

Dopamine

DARs:

Dopamine receptors

DAT:

DA transporter

DDC:

DOPA decarboxylase

GLU:

Glucagon

GSIS:

Glucose-stimulated insulin secretion

i.p.:

Intraperitoneal

IF:

Immunofluorescence

INS:

Insulin

IR:

Immunoreactivity

LAT:

l-amino acid transporter

l-DOPA:

Levodopa

MAO:

Monoamine oxidase

SST:

Somatostatin

TH:

Tyrosine hydroxylase

VMAT2:

Vesicular monoamine transporter 2

WB:

Western blot

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Authors and Affiliations

  1. Department of Physiology, School of Preclinical Medicine, Wannan Medical College, Wuhu, China

    Feng Hong

  2. Department of Physiology and Pathophysiology, School of Basic Medical Science, Capital Medical University, Beijing, China

    Feng Hong, Guang-Wen Li, Yan Zhang, Xiao-Yan Feng & Jin-Xia Zhu

  3. Department of Biology, College of Science and Health, University of Wisconsin-La Crosse, La Crosse, WI, USA

    Sumei Liu

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  1. Feng Hong
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  2. Guang-Wen Li
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  3. Sumei Liu
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  4. Yan Zhang
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  5. Xiao-Yan Feng
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  6. Jin-Xia Zhu
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Correspondence to Jin-Xia Zhu .

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  1. Physiology and Pathophysiology, Capital Medical University, Beijing, Beijing, China

    Jin-Xia Zhu

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Hong, F., Li, GW., Liu, S., Zhang, Y., Feng, XY., Zhu, JX. (2021). Dopamine in the Pancreas. In: Zhu, JX. (eds) Dopamine in the Gut. Springer, Singapore. https://doi.org/10.1007/978-981-33-6586-5_6

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