Abstract
Heavy metals are toxic contaminants that enter the human body from the environment. These contaminants have an impact on newborn leukocytes and may be associated with chromosomal changes that might alter the length of the leukocyte telomeres. Heavy metals often contaminate water and soil; consequently, accumulate in the food chain. The present investigation was conducted at the Institute of Public Health and Hygiene, New Delhi; considering 312 pregnant women and newborns. 200 people of all age groups were also taken into consideration. Urine samples were collected and analyzed through mass spectroscopy (ICP-MS). This study explores the progress of knowledge related to the toxic effects of heavy metals in pregnant woman and their neonates. Assessment of heavy metal concentration in maternal urine was done to examine prenatal heavy metal exposure. Arsenic, cadmium, chromium, and lead exposure were inversely related to birth weight, mortality, and effects on newborns. Blood smear preparations, qPCR chromosomal telomere length assay, inductively coupled plasma mass spectrometry (ICP-MS) study illustrates the effects of heavy metals. Correlation between prenatal exposures of toxic heavy metals (in the environment), and detrimental birth outcomes was evaluated. The effect of heavy metal inducing leukemia was significantly high in neonates than in adults.
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References
Malik DS, Maurya PK (2014) Heavy metal concentration in water, sediment, and tissues of fish species (Heteropneustis fossilis and Puntius ticto) from Kali River, India. Toxicol Env Chem 96(8):1195–1206
Wai KM, Mar O, Kosaka S et al (2017) Prenatal heavy metal exposure and adverse birth outcomes in Myanmar: a birth-cohort study. Int J Env Res Pub Health 14(11):1339. https://doi.org/10.3390/ijerph14111339
Rehman K, Fatima F, Waheed I, Akash MSH (2018) Prevalence of exposure of heavy metals and their impact on health consequences. J Cell Biochem 119(1):157–184. https://doi.org/10.1002/jcb.26234 Epub 2017 Aug 2 PMID: 28643849
Bacquart T, Frisbie S, Mitchell E et al (2015) Multiple inorganic toxic substances contaminating the groundwater of Myingyan Township, Myanmar: Arsenic, manganese, fluoride, iron, and uranium. Sci Tot Env 517:232–245
Barbu C, Popescu A, Selisteanu D, Preda A (2008) Determination of toxic heavy metals present in Jiu River Water using ICP-MS. Asia J Chem 20(3):2037–2046
Jan AT, Azam M, Siddiqui K et al (2015) Heavy metals and the human health: mechanistic insight into toxicity and counter defense system of antioxidants. Int J Mol Sci 16:29592–29630. https://doi.org/10.3390/ijms161226183
Beck S, Wojdyla D, Say L et al (2010) The worldwide incidence of preterm birth: a systematic review of maternal mortality and morbidity. Bulletin WHO 88:31–38
Lawn JE, Wilczynska-Ketende K, Cousens SN (2006) Estimating the causes of 4 million neonatal deaths in the year 2000. Int J Epi 35:706–718
Ministry of Health (MOH); The United Nations Children’s Fund (Unicef) (2013) An analysis of arsenic content in drinking water sources of Ayeyarwaddy Region. MOH, Naypyidaw, Myanmar
Ministry of Health and Sports (MOHS); ICF International. Demographic and Health Survey (2015–2016): Key Indicators Report. In: Myanmar Demographic and Health Survey (DHS); Ministry of Health and Sports (MOHS), Naypyidaw, Myanmar; The DHS Program ICF International, Rockville, MD, USA, 2016
Hanan FA (2012) Dietary habits and relation to cancer disease in different population. Arch Cancer Res 1(1:2): https://doi.org/10.3823/901
Rahman A, Persson L, Nermell B et al (2010) Arsenic exposure and risk of spontaneous abortion, stillbirth, and infant mortality. Epidem 21:797–804
World Health Organization (WHO), United Nations Children’s Fund (UNICEF) (2004) Low Birth Weight: Country, Regional and Global Estimate; United Nations Children’s Fund (UNICEF), New York, NY, USA
World Health Organization (WHO); United Nations Children’s Fund (UNICEF) (2004) Low Birth Weight: Country, Regional and Global Estimate; United Nations Children’s Fund (UNICEF), New York, NY, USA
Tun TN (2003) Arsenic contamination of water sources in rural Myanmar. In: Proceedings of the 29th WEDC international conference towards the Millennium Development Goals, Abuja, Nigeria, 22–26 Sep 2003, pp 219–221
Van Geen A, Win KH, Zaw T et al (2014) Confirmation of elevated arsenic levels in groundwater of Myanmar. Sci Tot Env 21–24
Al-Saleh I, Shinwari N, Mashhour A, Rabah A (2014) Birth outcome measures and maternal exposure to heavy metals, (lead, cadmium and mercury) in Saudi Arabian population. Int J Hyg Env Health 217:205–218
Gundacker C, Hengstschlager M (2012) The role of the placenta in fetal exposure to heavy metals. Wien Med Wochenschr 162:201–206
Rai PK, Lee SS, Zhang M (2019) Heavy metals in food crops: health risks, fate, mechanisms, and management. Env Int 125:365–385. https://doi.org/10.1016/j.envint.2019.01.067 Epub 2019 Feb 8 PMID: 30743144
Bamji MS (2011) Hazardous metals and minerals pollution in India: sources, toxicity and management. A Position Paper. Indian National, Published by Shri S. K. Sahni, Executive Secretary On Behalf of Indian National Science Academy, Bahadurshah Zafar Marg, New Delhi, Angkor Publishers (P) Ltd., Noida-201301
Quansah R, Armah FA, Essumang DK et al (2015) Association of arsenic with adverse pregnancy outcomes/infant mortality: a systematic review and meta-analysis. Env Health Pers 123(5):412–421. https://doi.org/10.1289/ehp.1307894
Wai KM, Umezaki M, Kosaka S et al (2018) Impact of prenatal heavy metal exposure on newborn leucocyte telomere length: a birth-cohort study. Env Pol 243(Pt B):1414–1421. https://doi.org/10.1016/j.envpol.2018.09.090 Epub 2018 Sep 21 PMID: 30278415
Vahter M (2009) Effects of arsenic on maternal and fetal health. Annu Rev Nutri 29:381–399
Zheng G, Zhong H, Guo Z et al (2014) Levels of heavy metals and trace elements in umbilical cord blood and the risk of adverse pregnancy outcomes: a population-based study. Bio Trace Elem Res 160:437–444
Blencowe H, Cousens S, Oestergaard MZ et al (2012) National, regional, and worldwide estimates of preterm birth rates in the year 2010 with time trends since 1990 for selected countries: a systematic analysis and implications. Lancet 379:2162–2172
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Kumar, K.M., Mukherjee, A. (2021). Impact of Heavy Metal Exposure on Newborn and Pregnant Women Associated with Leukocyte Carcinoma. In: Roy, P.K., Roy, M.B., Pal, S. (eds) Advances in Water Resources Management for Sustainable Use. Lecture Notes in Civil Engineering, vol 131. Springer, Singapore. https://doi.org/10.1007/978-981-33-6412-7_24
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