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Gut Bacterial Dysbiosis and Its Clinical Implications

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Probiotic Research in Therapeutics

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Abstract

The gut microbiota as it is collectively known, functions as an organ of the human body influencing various metabolic, immunologic and neurologic activities. Our understanding of this microbial community has drastically increased in the past decade owing to a burst in ‘omics’ sciences. A healthy microbiome is essential for energy harvest and normal functioning of other body processes beyond the gut. However, perturbances in the gut microbiota referred to as ‘dysbiosis’ are said to hamper the homeostatic condition and are implicated in the development of a number of diseases such as obesity, metabolic syndrome, diabetes, inflammation, etc. A number of factors such as antibiotic misuse, dietary lifestyle, etc. are said to lead to bacterial dysbiosis. Since the gut microbial community is largely composed of bacteria, understanding the composition, factors influencing dysbiosis and its implications in several diseases is important. Thus, this chapter focuses on highlighting the importance of the gut microbiota, factors responsible for dysbiosis, effects of dysbiosis leading to several conditions as well as scope for normalizing the dysbiotic state.

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  1. Division of Microbiology and Tissue Culture, School of Life Sciences, JSS Academy of Higher Education & Research, Mysuru, Karnataka, India

    Ann Catherine Archer

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  1. University Institute of Pharmaceutical Sciences, Chandigarh, Punjab, India

    Sandip V. Pawar

  2. Department of Microbiology, Panjab University, Chandigarh, Punjab, India

    Praveen Rishi

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Archer, A.C. (2021). Gut Bacterial Dysbiosis and Its Clinical Implications. In: Pawar, S.V., Rishi, P. (eds) Probiotic Research in Therapeutics. Springer, Singapore. https://doi.org/10.1007/978-981-33-6236-9_1

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