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Mesenchymal Stem Cell-derived Extracellular Vesicles for Skin Wound Healing

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Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1310)

Abstract

Skin is vulnerable to various external insults such as burn, severe injury, or inflammation, which necessitates a better strategy for wound repair. Mesenchymal stem cells (MSCs) can self-renew and differentiate into various supporting tissues including cartilage, bone, muscle, and adipose tissue. Along with their unique multipotent capacity, they secrete various paracrine mediators such as growth factors, cytokines, and membrane-enclosed particles called extracellular vesicles (EVs). Herein, we discussed the general traits of EVs such as cell-to-cell communicator, and highlighted the recent preclinical outcomes, with a focus on the application of MSC-derived EVs in wound repair. This chapter provides insights into developing novel strategies for skin wound healing in a cell-free manner.

Keywords

Extracellular vesicles Mesenchymal stem cells Wound healing 
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Copyright information

© Springer Nature Singapore Pte Ltd. 2021

Authors and Affiliations

  1. 1.Brexogen Inc.SeoulSouth Korea
  2. 2.Graduate School of International Agricultural Technology and Institute of Green-Bio Science and Technology, Pyeongchang Daero 1447Seoul National UniversityPyeongchangSouth Korea

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