Abstract
Congestive heart failure (CHF) is a systolic dysfunction of the heart in which the pumping efficiency or ejection fraction reduces and the body responses by compensatory mechanisms. Sympathetic activation and activating the RAAS help in the short run but are deleterious in the longer run and cause myocardial remodeling and apoptosis. Drugs which remove these stressors usually reduce mortality such as RAAS inhibitors, beta-blockers, mineralocorticoid antagonists and a combination of hydralazine and isosorbide dinitrate. Drugs which act to reduce congestion and other symptoms reduce preload (diuretics, nitrates) and afterload (RAAS inhibitors). Digoxin works uniquely by stimulating the heart but its use has come down because of its narrow therapeutic window and availability of better drugs. Newer agents include recombinant atrial natriuretic peptide and vasopeptidase inhibitors. Decompensated heart failure is treated by inotropic agents such as dopamine, dobutamine, and phosphodiesterase inhibitors.
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Entresto (sacubitril/valsartan) dosing, indications, interactions, adverse effects, and more. https://reference.medscape.com/drug/entresto-sacubitril-valsartan-1000010#10. Accessed 26 Dec 2019
Ezekowitz JA, O’Meara E, McDonald MA, Abrams H, Chan M, Ducharme A et al (2017) Comprehensive update of the canadian cardiovascular society guidelines for the management of heart failure. Canadian J Cardiol 33(11):1342–1433
Klabunde R (n.d.) Cardiovascular physiology concepts, atrial and brain natriuretic peptides. https://www.cvphysiology.com/Blood%20Pressure/BP017. Accessed 26 Dec 2019
Liu LC, Dorhout B, van der Meer P, Teerlink JR, Voors AA (2016) Omecamtiv mecarbil: a new cardiac myosin activator for the treatment of heart failure. Expert Opin Investig Drugs 25(1):117–127
Maron BA, Rocco TP (2011) Pharmacotherapy of congestive heart failure. In: Brunton LL, Chabner BA, Knollman BJ (eds) Goodman & Gilman’s the pharmacological basis of therapeutics, 12th edn. McGraw-Hill, New York, pp 789–813
Satoskar RS, Rege NN, Bhandarkar SD (2013) Pharmacotherapy of congestive heart failure. In: Pharmacology and pharmacotherapeutics, 23rd edn. Popular Prakashan, Mumbai, pp 447–464
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Shah, N.J. (2021). Drugs Used in Heart Failure. In: Paul, A., Anandabaskar, N., Mathaiyan, J., Raj, G.M. (eds) Introduction to Basics of Pharmacology and Toxicology. Springer, Singapore. https://doi.org/10.1007/978-981-33-6009-9_26
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DOI: https://doi.org/10.1007/978-981-33-6009-9_26
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