Skip to main content

Nitric Oxide, Vasoactive Peptides, and Purines

  • Chapter
  • First Online:
Introduction to Basics of Pharmacology and Toxicology
  • 2494 Accesses

Abstract

This chapter explains in detail, the role of nitric oxide pathway and its players, in health and disease. These players may be endogenous (activators or inhibitors) or exogenous (donors or inhibitors) in nature. Nitric oxide donors are clinically important since they have a major share to play in the management of several pathophysiological disorders. The chapter also throws light on the various vasoactive peptides that may be vasoconstrictors or vasodilators (or sometimes, mixed). Finally, the chapter also explains the role of purines in the management of various microbial disorders and cancers.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 189.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 249.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 249.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Similar content being viewed by others

Bibliography

  • Bilezikian JP, Raisz LG, Martin JT (eds) (2008) Principles of bone biology, 3rd edn. Elsevier, Amsterdam, pp 285–318

    Google Scholar 

  • Carroll GR (ed) (2007) Endocrine system. Elsevier, Amsterdam, pp 157–176

    Google Scholar 

  • Chandran S, Sridhar N, Veeranjaneyulu A (1998) Nitric oxide: concepts, current perspectives and future therapeutic implications. Indian J Pharmacol 30:351–366

    CAS  Google Scholar 

  • Despande SR, Satyanarayana K, Rao MNA, Pai KV (2012) Nitric oxide modulators: an emerging class of medicinal agents. Indian J Pharm Sci 74(6):487–497

    Article  Google Scholar 

  • Dinesh S, Shikha G, Bhavana G, Nidhi S, Dileep S (2012) Biological activities of purine analogues: a review. JPSI 1(2):29–34

    Google Scholar 

  • Gribble FM, Reimann F, Robert GP (2018) Gastrointestinal hormones. In: Said HM (ed) Physiology of gastrointestinal tract, 2nd edn. Elsevier, Amsterdam, pp 31–70

    Chapter  Google Scholar 

  • Huerta S, Chilka S, Bonavida B (2008) Nitric oxide donors: novel cancer therapeutics (review). Int J Oncol 33(5):909–927

    CAS  PubMed  Google Scholar 

  • Kastin AJ (ed) (2013) Somatostatin, 2nd edn. Elsevier, Amsterdam, pp 1320–1329

    Google Scholar 

  • Kusserow H, Unger T (2004) Vasoactive peptides, their receptors and drug development. Basic Clin Pharmacol Toxicol 94(1):5–12

    Article  CAS  Google Scholar 

  • Said SI (1983) Vasoactive peptides. State-of-the-art review. Hypertension 5(2 Pt 2):I17–I26

    CAS  PubMed  Google Scholar 

  • Somerville RL (2001) Purine. In: Brenner S, Miller JH (eds) Encyclopedia of genetics. Elsevier, Amsterdam, p 1585

    Chapter  Google Scholar 

  • Treschan TA, Peters J (2006) The vasopressin system: physiology and clinical strategies. Anesthesiology 105(3):599–612

    Article  CAS  Google Scholar 

  • Vrachnis N, Malamas MF, Sifakis S, Deligeoroglou E, Iliodromiti Z (2011) The oxytocin-oxytocin receptor system and its antagonists as tocolytic agents. Int J Endocrinol 2011:350546

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Rinz Mathew Paulose .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2021 Springer Nature Singapore Pte Ltd.

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Paulose, R.M. (2021). Nitric Oxide, Vasoactive Peptides, and Purines. In: Paul, A., Anandabaskar, N., Mathaiyan, J., Raj, G.M. (eds) Introduction to Basics of Pharmacology and Toxicology. Springer, Singapore. https://doi.org/10.1007/978-981-33-6009-9_22

Download citation

Publish with us

Policies and ethics