Abstract
Progression of Chronic Myeloid Leukemia from chronic phase to accelerated phase to blast crisis is often associated with secondary chromosomal aberrations, such as trisomy 8, trisomy 19, duplication of Ph chromosome, isochromosome 17 q, acquisition of t(1;21) or translocations and inversions associated with AML/Myelodysplasia and show complex karyotypes.
The following case studies describe the karyotypic features in lymphoid as well as myeloid blast crisis in patients of CML. Cases only in blast crisis and not classic CML have been selected for additional chromosomal abnormalities demonstrated on cytogenetics (Annexure).
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Annexure
Annexure
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Case Study 7.1: Chronic Myeloid Leukemia with Lymphoid Blast crisis with rare dic (7;9)
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Case Study 7.2: Chronic Myeloid Leukemia in Myeloid Blast Crisis with Hyperdiploid Complex Karyotype
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Case Study 7.3: Chronic Myeloid Leukemia in Myeloid Blast Crisis with t(9;22) and inv(16)
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Case Study 7.4: Chronic Myeloid Leukemia in Myeloid Blast Crisis with a novel dic(16;17) and TP53 Gene Deletion
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Bhargava, M. (2021). Chronic Myeloid Leukemia. In: Hematologic Malignancies. Springer, Singapore. https://doi.org/10.1007/978-981-33-4799-1_7
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DOI: https://doi.org/10.1007/978-981-33-4799-1_7
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