Skip to main content

New Markers of Acute Kidney Injury in Children Undergoing Hematopoietic Stem Cell Transplantation

  • 340 Accesses

Abstract

Acute kidney injury (AKI) is one of the common complications in children after hematopoietic stem cell transplantation (HSCT). Unfortunately, the current diagnostic methods are imperfect and may underestimate AKI occurrence. Therefore, creatinine-based evaluations should be enriched with more efficient tools. The new classification of AKI takes into account both glomerular function and features of cell damage, distinguishing between functional AKI (decreased function, no damage), subclinical AKI (proper function, damage present), and combined AKI (decreased function, damage to the tubules). The combination of serum creatinine, serum cystatin C and urinary NGAL turned out useful in AKI diagnosis and prediction of renal outcome in children undergoing HSCT, confirming that the analysis of multiple markers gives better results than measurements of single parameters. Further research on the concurrent analysis of markers of glomerular function (serum creatinine and cystatin C) and urinary indices of tubular damage (NGAL, L-FABP or association of IGFBP-7 and TIMP-2 [IGFBP-7]x[TIMP-2]), may broaden the group of patients with diagnosed AKI, thus facilitating early diagnosis, effective intervention and prevention of progression into chronic kidney disease.

This is a preview of subscription content, access via your institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • DOI: 10.1007/978-981-33-4554-6_14
  • Chapter length: 8 pages
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
eBook
USD   89.00
Price excludes VAT (USA)
  • ISBN: 978-981-33-4554-6
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
Softcover Book
USD   119.99
Price excludes VAT (USA)
Hardcover Book
USD   169.99
Price excludes VAT (USA)
Fig. 14.1

References

  1. Raina R, Herrera N, Krishnappa V, Sethi SK, Deep A, Kao W-M, et al. Hematopoietic stem cell transplantation and acute kidney injury in children: a comprehensive review. Pediatr Transplant. 2017;21(4):e12935.

    Google Scholar 

  2. Teo SH, Endre ZH. Biomarkers in acute kidney injury (AKI). Best Pract Res Clin Anaesthesiol. 2017;31:331–44.

    Google Scholar 

  3. Sutherland SM, Byrnes JJ, Kothari M, Longhurst CA, Dutta S, Garcia P, et al. AKI in hospitalized children: comparing the pRIFLE, AKIN, and KDIGO definitions. Clin J Am SocNephrol. 2015;10(4):554–61.

    Google Scholar 

  4. Akcan-Arikan A, Zappitelli M, Loftis LL, Washburn KK, Jefferson LS, Goldstein SL. Modified RIFLE criteria in critically ill children with acute kidney injury. Kidney Int. 2007;71:1028–35.

    Google Scholar 

  5. Murray PT, Mehta RL, Shaw A, Ronco C, Endre Z, et al. Potential use of biomarkers in acute kidney injury: report and summary of recommendations from the 10th acute dialysis quality initiative consensus conference. Kidney Int. 2014;85:513–21.

    Google Scholar 

  6. Benoit SW, Dixon BP, Goldstein SL, Bennett MR, Lane A, et al. A novel strategy for identifying early acute kidney injury in pediatric hematopoietic stem cell transplantation. Bone Marrow Transplant. 2019. https://doi.org/10.1038/s41409-018-0428-6.

  7. Sanjeevani S, Pruthi S, Kalra S, Goel A, Kalra OP. Role of neutrophil gelatinase-associated lipocalin for early detection of acute kidney injury. Int J Crit Illn Inj Sci. 2014;4:223–8.

    Google Scholar 

  8. Shingai N, Morito T, Najima Y, Igarashi A, Kobayashi T, et al. Urinary liver-type fatty acid-binding protein linked with increased risk of acute kidney injury after allogeneic stem cell transplantation. Biol Blood Marrow Transplant. 2014;20:2010–4.

    Google Scholar 

  9. Bennett MR, Nehus E, Haffner C, Ma Q, Devarajan P. Pediatric reference ranges for acute kidney injury biomarkers. Pediatr Nephrol. 2015;30:677–85.

    Google Scholar 

  10. Di Somma S, Zampini G, Vetrone F, Soto-Ruiz KM, Magrini L, et al. Opinion paper on utility of point-of-care biomarkers in the emergency department pathways decision making. Clin Chem Lab Med. 2014;52:1401–7.

    Google Scholar 

  11. Pickering JW, Endre ZH. Bench to bedside: the next steps for biomarkers in acute kidney injury. Am J Physiol Renal Physiol. 2016;311:F717–21.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Kinga Musiał .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and Permissions

Copyright information

© 2021 Springer Nature Singapore Pte Ltd.

About this chapter

Verify currency and authenticity via CrossMark

Cite this chapter

Musiał, K., Zwolińska, D. (2021). New Markers of Acute Kidney Injury in Children Undergoing Hematopoietic Stem Cell Transplantation. In: Sethi, S.K., Raina, R., McCulloch, M., Bunchman, T.E. (eds) Advances in Critical Care Pediatric Nephrology. Springer, Singapore. https://doi.org/10.1007/978-981-33-4554-6_14

Download citation

  • DOI: https://doi.org/10.1007/978-981-33-4554-6_14

  • Published:

  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-33-4553-9

  • Online ISBN: 978-981-33-4554-6

  • eBook Packages: MedicineMedicine (R0)