Abstract
The analysis of a multitude of genes in one shot has been made possible with the introduction of microarrays to the scientific community. Microarrays are microscopic slides that are printed with thousands of tiny spots with each spot containing a specific nucleotide (known DNA). These nucleotides act as probes to detect the expression of the desired gene (mRNA). With growing scientific knowledge over the years, microarrays have found applications in a plethora of research specializations such as gene discovery, mutational analysis, detection of single nucleotide polymorphisms, identification and detection of microorganisms, and detection of clinical conditions such as cancer, heart diseases, neurological disorders, etc. Detection and diagnosis of such clinical conditions are now relatively easy with techniques such as microarrays, and timely therapeutic intervention is now no more a farfetched dream. Microarrays are these days being used to their full potential as elucidated by a variety of studies suggesting that the utility of microarrays will continue to grow in the forthcoming years as viable detection and identification methods.
Keywords
- Microarray
- SNPs
- CNVs
- Gene expression
- Mutational analysis
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Khurana, S., Bose, S., Kumar, D. (2019). Applications of Microarray-Based Technologies in Identifying Disease-Associated Single Nucleotide Variations. In: Tripathi, V., Kumar, P., Tripathi, P., Kishore, A., Kamle, M. (eds) Microbial Genomics in Sustainable Agroecosystems. Springer, Singapore. https://doi.org/10.1007/978-981-32-9860-6_4
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