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Plasticizer Exposure and Reproductive Health: Phthalates and Bisphenol A

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Emerging Chemicals and Human Health

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Abstract

Phthalates and bisphenol A are among the most popular plasticizers used today, which are ubiquitous environmental chemical pollutants with endocrine disruption. In this chapter, we summarize the basic characteristics of phthalates and bisphenol A and their effects on male and female reproductive health. We focus on the effects of phthalates exposure on testosterone level, anogenital distance, semen quality and hypospadias incidence in the male, as well as on precocious puberty, endometriosis, abnormalities of pregnancy in the female. Moreover, the effects of bisphenol A exposure on male semen quality, reproductive cells, sex hormones and female steroid hormone levels, reproductive organ diseases, and adverse birth outcomes are discussed. Results indicate that exposure to phthalates and bisphenol can adversely affect male and female reproductive health. However, evidence is still controversial. More large-scale prospective cohort studies are needed to verify the effects of plasticizer exposure on reproductive health in humans.

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Authors and Affiliations

  1. School of Public Health, Fudan University, Shanghai, China

    Pengpeng Wang

  2. Key Laboratory of Public Health Safety, Ministry of Education, Fudan University, Shanghai, China

    Pengpeng Wang

  3. Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, China

    Yan Zhao

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  1. Pengpeng Wang
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  1. Key Laboratory of Health Technology Assessment, National Health Commission of the People’s Republic of China, Fudan University, Shanghai, China, Key Laboratory of Public Health Safety, Ministry of Education, Fudan University, Shanghai, China

    Yunhui Zhang

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Wang, P., Zhao, Y. (2019). Plasticizer Exposure and Reproductive Health: Phthalates and Bisphenol A. In: Zhang, Y. (eds) Emerging Chemicals and Human Health. Springer, Singapore. https://doi.org/10.1007/978-981-32-9535-3_4

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