Preventive and Therapeutic Effect of Ganoderma (Lingzhi) on Liver Injury

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1182)


Ganoderma lucidum (G. lucidum, Lingzhi) has a wide range of hepatoprotective effects. Its bioactive substances include triterpenoids, polysaccharides, sterols, steroids, peptides, and other bioactive ingredients. Based on our research and other references, this chapter discusses the hepatoprotective effects of G. lucidum in different liver diseases, including hepatocellular carcinoma, nonalcoholic liver disease, alcoholic liver disease, hepatitis B, inflammation, fibrosis, and toxicant-induced liver injury. The liver protective mechanisms of G. lucidum vary from diseases to diseases. This chapter will summarize the hepatoprotective effects of G. lucidum on different liver injury and their clinical applications.


Ganoderma Lingzhi Polysaccharides Triterpenes Liver injury 



Research in the authors’ laboratory is supported by National Natural Science Foundation of China grants 81620108029, 81330074, 81261160507, 81974083, and 81170632, Beijing National Natural Science Foundation grant 7172113, and 111 project.


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© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  1. 1.State Key Laboratory of Natural and Biomimetic Drugs, Department of Pharmacology, School of Basic Medical SciencesPeking UniversityBeijingChina
  2. 2.Department of Pharmacology, School of Basic Medical SciencesPeking UniversityBeijingChina

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