Abstract
Cardiovascular diseases (CVDs) are disorders of the heart and blood vessels and include coronary heart diseases, cerebrovascular diseases, rheumatic heart diseases, and other conditions. CVDs are one of the most major causes of morbidity and mortality around the world, taking the lives of 17.9 million people every year. Several investigations have shown the influence of Ganoderma lucidum (G. lucidum, Lingzhi) on some metabolic markers, such as low-density lipoprotein (LDL), high-density lipoprotein (HDL), total cholesterol (TC), blood pressure, and oxidative damage. G. lucidum potentially reduces the risk of suffering cardiovascular diseases. Some studies found that G. lucidum prevented from heart damage in a variety of disease models, such as streptozotocin (STZ)-induced diabetic, high-fat-diet-induced diabetic, isoprenaline (ISO)-induced myocardial hypertrophy, acute ethanol-induced heart toxicity, and transverse aortic constriction (TAC) models. This chapter summarizes putative preventive and therapeutic effects of G. lucidum on cardiovascular diseases and the potential clinical use of G. lucidum involved in these effects.
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Acknowledgments
Research in the authors’ laboratory is supported by National Natural Science Foundation of China grants 81620108029, 81330074, 81261160507, 81974083 and 81170632, Beijing Natural Science Foundation grant 7172113, Drug Discovery Program grant 2009ZX09301-010-30, the Research Fund for the Doctoral Program of Higher Education 20100001110047, the 111 project, and International Science and Technology Cooperation Program of China 2012DFA11070.
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Meng, J., Yang, B. (2019). Protective Effect of Ganoderma (Lingzhi) on Cardiovascular System. In: Lin, Z., Yang, B. (eds) Ganoderma and Health. Advances in Experimental Medicine and Biology, vol 1182. Springer, Singapore. https://doi.org/10.1007/978-981-32-9421-9_7
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DOI: https://doi.org/10.1007/978-981-32-9421-9_7
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