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Implication of Quorum Sensing and Biofilm Formation in Medicine, Agriculture and Food Industry pp 189–217Cite as

Antimicrobial and Anti-quorum Sensing Activities of Medicinal Plants

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Abstract

Medicinal plants have been used for several centuries for prevention, treatment, and cure of diseases. The study of many of these traditional medicinal plants has led to the isolation and characterization of bioactive compounds. Some of these compounds have been chemically modified and used as drugs to mitigate ailments. Several commercially available antibiotics are derived from plants. The rise of multidrug-resistant strains of pathogens has led to an intensive search for compounds that can curb this alarming trend. The phenomenon of quorum sensing sheds a whole new light on the process of mitigation of microbial infection, where the plant-derived compounds block essential pathways (like virulence factor expression and biofilm formation) controlled by quorum sensing. Since the discovery that halogenated furanones produced by red marine algae Delisea pulchra can interfere with the process of quorum sensing in several Gram-negative bacteria, several medicinal plants (Mentha piperita, Syzygium aromaticum, Rosmarinus officinalis, Jasminum sambac, Lilium brownii, Ocimum sanctum, etc.) have been assessed for anti-quorum sensing potential. Some of them possess only anti-quorum sensing activity, and a few others possess both antimicrobial and anti-quorum sensing activity. Some studies have also identified the compounds responsible for inhibition of quorum sensing pathways. This chapter discusses the study of medicinal plants for their anti-quorum sensing activity.

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References

  • Abourashed EA, El-Alfy AT, Khan IA, Walker L (2003) Ephedra in perspective- a current review. Phytother Res 17:703–712

    Article  CAS  PubMed  Google Scholar 

  • Adonizio A, Kong K, Mathee K (2008) Inhibition of quorum sensing-controlled virulence factor production in Pseudomonas aeruginosa by South Florida plant extracts. Antimicrob Agents Chemother 52(1):198–203

    Article  CAS  PubMed  Google Scholar 

  • Agyemang K, Han L, Liu E, Zhang Y, Wang T, Gao X (2013) Recent advances in Astragalus membranaceus anti-diabetic research: pharmacological effects of its phytochemical constituents. Evid Based Complement Alternat Med 2013:654643

    Article  PubMed  PubMed Central  Google Scholar 

  • Albuquerque P, Casadevall A (2012) Quorum sensing in fungi- a review. Med Mycol 50(4):337–345

    Article  CAS  PubMed  Google Scholar 

  • Al-Hussaini R, Mahasneh AM (2009) Microbial growth and quorum sensing antagonist activities of herbal plant extracts. Molecules 14:3425–3435

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Bacha K, Tariku Y, Gebreyesus F, Zerihun S, Mohammed A, Weiland-Brauer N, Schmitz RA, Mulat M (2016) Antimicrobial and anti-quorum sensing activities of selected medicinal plants of Ethiopia: implication for development of potent antimicrobial agents. BMC Microbiol 16(139)

    Google Scholar 

  • Bassler BL (2002) Small talk: cell-to-cell communication in bacteria. Cell 109:421–424

    Article  CAS  PubMed  Google Scholar 

  • Bora KB, Sharma A (2011) Evaluation of antioxidant and Cerebroprotective effect of Medicago sativa Linn. against ischemia and reperfusion insult. Evid Based Complement Alternat Med 2011, 9 pages. Article ID 792167. https://doi.org/10.1093/ecam/neq019. Hindawi Publishing Corporation

    Article  Google Scholar 

  • Chong YM, Yin WF, Ho CY, Mustafa MR, Hamid A, Hadi A, Awang K, Narrima P, Koh C, Appleton DR, Chan K (2011) Malabaricone C from Myristica cinnamomea exhibits anti-quorum sensing activity. J Nat Prod 74:2261–2264

    Article  CAS  PubMed  Google Scholar 

  • Correa GM, Alcantara AF (2011) Chemical constituents and biological activities of species of Justicia- a review. Braz J Pharmacog 22(1):220–238

    Article  CAS  Google Scholar 

  • Cortes-Rojas DF, Fernandes de Souza CR, Oliveria WP (2014) Clove (Syzygium aromaticum): a precious spice. Asian Pac J Trop Biomed 4(2):90–96

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Dudonné S, Poupard P, Coutière P, Woillez M, Richard T, Mérillon J, Vitrac X (2011) Phenolic composition and antioxidant properties of poplar bud (Populus nigra) extract: individual antioxidant contribution of phenolics and transcriptional effect on skin aging. J Agric Food Chem 59(9):4527–4536

    Article  PubMed  CAS  Google Scholar 

  • Gangwar AK, Ghosh AK (2014) Medicinal uses and pharmacological activity of Adhatoda vasica. Int J Herb Med 2(1):88–91

    Google Scholar 

  • Habtemariam S (2016) The therapeutic potential of rosemary (Rosmarinus officinalis) Diterpenes for Alzheimer’s disease. Evid Based Complement Alternat Med 2016:1

    Article  Google Scholar 

  • Haouat AC, El Guendouzi S, Haggoud A, David S, Sqalli H, Ibnsouda S, Iraqui M (2013) Antimycobacterial activity of Populus alba leaf extracts. J Med Plants Res 7(16):1015–1021

    Google Scholar 

  • Head K (2004) Angelica sinensis (Dong quai). Altern Med Rev 9(4):429–433

    Google Scholar 

  • Hentrez M, Givskov M (2003) Pharmacological inhibition of quorum sensing for the treatment of chronic bacterial infections. J Clin Invest 112(9):1300–1307

    Article  Google Scholar 

  • Ho M, Hsieh Y, Chen J, Chen K, Chen J, Kuo W, Lin S, Chen P (2011) Antimetastatic potentials of Dioscorea nipponica on melanoma in vitro and in vivo. Evid Based Complement Alternat Med 2011:1

    Google Scholar 

  • Hogan DA (2015) Talking to themselves: autoregulation and quorum sensing in fungi. Eukaryot Cell 5(4):613–619

    Article  CAS  Google Scholar 

  • Hossain MF, Akhtar S, Anwar M (2015) Nutritional value and medicinal benefits of pineapple. Int J Nutr Food Sci 4(1):84–88

    Article  CAS  Google Scholar 

  • Jaiswal P, Kumar P, Singh VK, Singh DK (2011) Areca catechu L.: a valuable herbal medicine against different health problems. Res J Med Plant 5920:145–152

    Google Scholar 

  • Jurenka J (2008) Therapeutic application of pomegranate (Punica granatum L.): a review. Altern Med Rev 13(2):128–144

    PubMed  Google Scholar 

  • Kalia VC (2013) Quorum sensing inhibitors: an overview. Biotechnol Adv 31:224–245

    Article  CAS  PubMed  Google Scholar 

  • Kalita S, Kumar G, Karthik L, Rao KVB (2012) A review on medicinal properties of Lantana camara Linn. Res J Pharm Technol 5(6):711–715

    Google Scholar 

  • Khan MSA, Zahin M, Hasan S, Husain FM, Ahmad I (2008) Inhibition of quorum sensing regulated bacterial functions by plant essential oils with special reference to clove oil. Lett Appl Microbiol 49:354–360

    Article  CAS  Google Scholar 

  • Khushbu C, Roshni S, Anar P, Carol M, Mayuree P (2011) Phytochemical and therapeutic potential of Piper longum Linn a review. Int J Res Ayurveda Pharm 2(1):157–161

    Google Scholar 

  • Koh KH, Tham F (2011) Screening of traditional Chinese medicinal plants for quorum-sensing inhibitors activity. J Microbiol Immunol Infect 44:144–148

    Article  PubMed  Google Scholar 

  • Koh C, Sam C, Yin W, Tan L, Krishnan T, Chong Y, Chan K (2013) Plant-derived natural products as sources of anti-quorum sensing compounds. Sensors 13:6217–6228

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kokila K, Priyadharshini SD, Sujatha V (2013) Phytopharmacological properties of Albizia species: a review. Int J Pharm Pharm Sci 5(3):70–73

    CAS  Google Scholar 

  • Kumar T, Chandrashekar KS (2011) Bauhinia purpurea Linn.: a review of its ethnobotany, phytochemical and pharmacological profile. Res J Med Plant 5(4):420–431

    Article  CAS  Google Scholar 

  • Kumar D, Arya V, Bhat ZA, Khan NA, Prasad DN (2012) The genus Crataegus: chemical and pharmacological perspectives. Braz J Pharmacol 22:1187

    Article  CAS  Google Scholar 

  • Lis-Balchin M, Hart S (1999) Studies on the mode of action of the essential oil of lavender Lavandula angustifolia P. Miller. Phytother Res 13(6):540–542

    Article  CAS  PubMed  Google Scholar 

  • McLean RJC, Pierson III LS, Fuqua C (2004) A simple screening protocol for the identification of quorum signal antagonists. J Microbiol Methods 58:351–360

    Article  CAS  PubMed  Google Scholar 

  • Mounika SC (2016) A review on medicinal importance of Babchi (Psoralea corylifolia). Int J Recent Sci Res 7(6):11504–11512

    Google Scholar 

  • Nandal U, Bhardwaj RL (2012) Aloe vera: a valuable wonder plant for food, medicine and cosmetic use- a review. Int J Pharm Sci Rev Res 13(1):59–67

    Google Scholar 

  • Nayar MP, Sastry ARK (1990) Red data book on Indian plants, vol 3. Botanical Survey of India, Calcutta, pp 28–29

    Google Scholar 

  • Neeraj S, Sushila K, Dheeraj D, Millind P, Minakshi P (2014) Garlic: a pungent wonder from nature. Int Res J Pharm 5(7):523–529

    Article  Google Scholar 

  • Ng TB (2006) Pharmacological activity of Sanchi ginseng (Panax notoginseng). J Pharm Pharmacol 58(8):107–119

    Article  CAS  Google Scholar 

  • Okubo H, Hiramatsu M, Masuda J, Sakazono S (2012) New insight into Lilium brownie var. volchesteri. Floricult Ornament Biol 6(2):44–52

    Google Scholar 

  • Milind P, Preeti (2015) Chickoo: a wonderful gift from nature. Int J Res Ayurveda Pharm 6(4):544–550

    Article  CAS  Google Scholar 

  • Packiavathy IASV, Agilandeswari P, Musthafa KS, Pandian SK, Ravi AV (2012) Antibiofilm and quorum sensing inhibitory potential of Cuminum cyminum and its secondary metabolite methyl eugenol against gram negative bacterial pathogens. Food Res Int 45:85–92

    Article  CAS  Google Scholar 

  • Parada M, Carrio E, Bonet MA, Valles J (2009) Ethanobotany of the Alt Emporda region (Catalonia, Iberian Peninsula). Plants Used Hum Trad Med 124:609–618

    Google Scholar 

  • Parvathy NG, Padma AR, Renjith V, Rahate KP, Saranya TS (2012) Phytochemical screening and anti-helmenthic activity of methanolic extract of Imperata cylindrica. Int J Pharm Pharm Sci 4(1):232–234

    CAS  Google Scholar 

  • Parvez GMM (2016) Pharmacological activities of mango (Mangifera indica): a review. J Pharmacogn Phytochem 5(3):01–07

    CAS  Google Scholar 

  • Patrakar R, Mansuriya M, Patil P (2012) Phytochemical and pharmacological review on Laurus nobilis. J Med Plants Res 1(2):597–602

    Google Scholar 

  • Paudel KR, Panth N (2015) Phytochemical profile and biological activity of Nelumbo nucifera. Evid Based Complement Alternat Med 2015:1–16

    Article  Google Scholar 

  • Preston RE (2012) Flora of North America. Taxon eds, Freeman & Rabeler, p 17

    Google Scholar 

  • Rahman S, Islam I, Kamruzzaman M, Alam K, Jamal AHM (2011) Ocimum sanctum L.: a review of phytochemical and pharmacological profile. Am J Drug Discov Devel. https://doi.org/10.3923/ajdd.2011. ISSN 2150-427x, © 2011 Academic Journals Inc

  • Raj V, Jain A, Chaudhary J (2012) Prunus armeniaca (Apricot): an overview. J Pharm Res 5(8):3964–3966

    CAS  Google Scholar 

  • Rao PV, Gan SH (2014) Cinnamon: a multifaceted medicinal plant. Evid Based Complement Alternat Med 2014:1

    Article  Google Scholar 

  • Rasool R, Ganai BA (2013) Prunella vulgaris L.: a literature review on its therapeutic potentials. Pharmacologia 4(6):441–448

    Article  CAS  Google Scholar 

  • Rungruangmaitree R, Jiraungkoorskul W (2017) Pea, Pisum sativum and its anticancer activity. Pharmacog Rev 11(21):39–42

    Article  CAS  Google Scholar 

  • Sabharwal S, Sudan S, Ranjan V (2013) Jasminum sambac Linn (Motia): a review. Int J Pharm Res Bio Sci 2(5):108–130

    Google Scholar 

  • Saini NK, Singhal M (2012) Evaluation of anti-nociceptive activity of Methanolic extract of Tecoma capensis Thunb. (Bignoniaceae) leaves in rats. Asian Pac J Trop Med 5:781–784

    Article  CAS  PubMed  Google Scholar 

  • Selvam ABD (2012) Pharmacognosy of negative listed plants. Botanical Survey of India, Ministry of Environment and Forests, Kolkata, pp 138–148

    Google Scholar 

  • Shah PP, D’Mello PM (2004) A review of medicinal uses and pharmacological effects of Mentha piperita. Nat Prod Rad 3(4):214–221

    Google Scholar 

  • Shen J, Man K, Huang P, Chen W, Chen D, Chen Y, Liu P, Chou M, Chen Y (2010) Honokiol and Magnolol as multifunctional antioxidative molecules for dermatologic disorders. Molecules 15:6452–6465

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Siew-Mian S, Tham F (2012) Anti-quorum sensing and antimicrobial activities of some traditional Chinese medicinal plants commonly used in South-East Asia. Malays J Microbiol 8(1):11–20

    Google Scholar 

  • Singh BN, Singh BR, Singh RL, Prakash D, Dhajarey R, Upadhyay G, Singh HB (2009a) Oxidative DNA damage protective activity, antioxidant activity and anti-quorum sensing potentials of Moringa oleifera. Food Chem Toxicol 47:1109–1116

    Article  CAS  PubMed  Google Scholar 

  • Singh BN, Singh BR, Singh RL, Prakash D, Dhajarey R, Upadhyay G, Singh HB (2009b) Oxidative DNA damage protective activity, antioxidant activity and anti-quorum sensing potentials of Moringa oleifera. Food Chem Toxicol 47:1109–1116

    Article  CAS  PubMed  Google Scholar 

  • Singh BN, Singh BR, Singh RL, Prakash D, Sharma BK, Singh HB (2009c) Antioxidant and anti-quorum sensing activities of green pod of Acacia nilotica L. Food Chem Toxicol 47:778–786

    Article  CAS  PubMed  Google Scholar 

  • Sinha S, Sharma A, Reddy PH, Rathi B, Prasad NVSRK, Vashistha A (2013) Evaluation of phytochemical and pharmacological aspects of Holarrhena antidysenterica (Wall.): a comprehensive review. J Pharm Res 6:488–492

    CAS  Google Scholar 

  • Vilelathor FC, Padilha MM, Santos-e-Silva L, Alves-da-Silva G, Giusti-Paiva A (2009a) Evaluation of the antinociceptive activity of extracts of Sonchus oleraceus L. in mice. J Ethnopharmacol 124(2):306–310

    Article  Google Scholar 

  • Zahin M, Hasan S, Aqil F, Khan MSA, Husain FM, Ahmad I (2010a) Screening of certain medicinal plants for their anti-quorum sensing activity. Indian J Exp Biol 48:1219–1224

    PubMed  Google Scholar 

  • Zaki AA, Shaaban MI, Hashish NE, Amer MA, Lahloub M (2012) Assessment of anti-quorum sensing activity of some ornamental and medicinal plants native to Egypt. Sci Pharm 81:251–258

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Waters CM, Bassler BL (2005) Quorum sensing: cell-to-cell communication in Bacteria. Annu Rev Cell Dev Biol 21:319–346

    Article  CAS  PubMed  Google Scholar 

  • Winzer K, Williams P (2001) Quorum sensing and the regulation of virulence gene expression in pathogenic bacteria. Int J Med Micobiol 291:131–143

    Article  CAS  Google Scholar 

  • Zahin M, Hasan S, Aqil F, Khan MSA, Husain FM, Ahmad I (2010b) Screening of certain medicinal plants for their anti-quorum sensing activity. Indian J Exp Biol 48:1219–1224

    PubMed  Google Scholar 

  • Vilelathor FC, Padilha MM, Santos-e-Silva L, Alves-da-Silva G, Giusti-Paiva A (2009b) Evaluation of the antinociceptive activity of extracts of Sonchus oleraceus L. in mice. J Ethnopharmacol 124(2):306–310

    Article  Google Scholar 

  • Yarnell E, Abascal K (2009) Dandelion (Taraxacum officinale and T mongolicum). Integrative Med 8(2):35–38

    Google Scholar 

  • Weissner W (2014) Anantamul (Hemidesmus indicus): a review of biomedical studies and U.S. products. Ayurveda J Health XII(4):40–52

    Google Scholar 

  • Zhang Z, Leung W, Cheung H, Chan C (2015) Osthole: a review on its bioactivities, pharmacological properties and potential as alternative medicine. Evid Based Complement Alternat Med 2015:916916

    Google Scholar 

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Authors and Affiliations

  1. Department of Biotechnology, College of Science and Technology, Andhra University, Visakhapatnam, Andhra Pradesh, India

    Angela E. Peter, Pola Sudhakar & B. V. Sandeep

  2. College of Pharmaceutical Sciences, Andhra University, Visakhapatnam, Andhra Pradesh, India

    B. Ganga Rao

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  1. Angela E. Peter
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  2. Pola Sudhakar
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  3. B. V. Sandeep
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  4. B. Ganga Rao
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Correspondence to Pola Sudhakar .

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  1. Department of Biotechnology, Krishna University, Machilipatnam, Andhra Pradesh, India

    Pallaval Veera Bramhachari

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Peter, A.E., Sudhakar, P., Sandeep, B.V., Rao, B.G. (2019). Antimicrobial and Anti-quorum Sensing Activities of Medicinal Plants. In: Bramhachari, P. (eds) Implication of Quorum Sensing and Biofilm Formation in Medicine, Agriculture and Food Industry . Springer, Singapore. https://doi.org/10.1007/978-981-32-9409-7_14

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