Biofilm Formation on Ophthalmic Device-Related Infections: Insights on Clinical Implications

Abstract

Biofilms are structured communities of microorganisms which are encased within a self-produced matrix attached to surface of abiotic or biotic. There is growing evidence that bacterial biofilms play a major lead in a range of ocular infections. The presence of biofilms has been established on most indwelling ophthalmic devices such as intraocular lenses, scleral buckles, contact lenses and suture materials. Lack of poor lens hygiene leads to infections of soft lenses that are at high risk than other types of lenses. Pseudomonas spp. is gram-negative bacteria predominant on contact lenses. Serratia spp. and Staphylococcus spp. are the next dominant microorganisms in the eye. The biofilm of these organisms led to activation of various signalling cascades which cause permanent vision loss in humans. The strategy of preventing the microbial attachment and biofilm formation by utilizing single-cell repellent surfaces is the ideal choice. Natural and man-made anti-biofilm compounds have previously been discovered to address this problem. There is a large requirement for improvement of anti-biofilm formulations to control the post-surgery eye medical devices. The organoselenium polypropylene is the one which demonstrates the capacity to decrease biofilm formation. The utilization of organoselenium copolymer assumes an indispensable job in securing against contact focal point. Nisin polypropylene material showed to stop the biofilm formation of S. epidermidis. The review emphasizes on biofilm formation on ophthalmic devices and advanced developments in the anti-biofilm materials for better vision.

All authors contributed equally