Abstract
Skeletal muscle aging is the primary factor limiting the scope of human activities and quality of life. Aging of cardiac muscle impairs delivery of oxygen and substrates to the energy-demanding organs of the body affecting their function. Thus, both the muscles taken together largely determine the pace of aging in an individual. With improvement in medical system, the life expectancy has increased dramatically in the last century, which has resulted in a huge increase in the number of those considered aged. In recent decades, the number of people with metabolic disorders, including type 2 diabetes, hypertension, and hyperlipidemia, has been increasing steadily. Diabetes and hyperlipidemia are very closely intertwined with muscle aging, which in turn speeds up the clinical manifestation of the disorders. Muscle protein synthesis, mitochondrial biogenesis, and adenosine triphosphate (ATP) production are significantly affected by both aging and metabolic disorders. During aging, levels of anabolic hormones, such as testosterone, growth hormone, and insulin-like growth factor (IGF)-1 decrease and that of catabolic agents like interleukin 6 (IL-6) increases, contributing to muscle wasting among the elderly individuals. Incorporation of increased physical activity (including exercise) in routine life has been demonstrated to reduce the pace of aging, thereby promoting healthy aging.
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Books and book chapters
Askanas V, Engel WK. Muscle Aging, Inclusion-Body Myositis and Myopathies: Blackwell Publishing Ltd; 2011. https://doi.org/10.1002/9781444398311.
Lynch GS. Sarcopenia – Age-Related Muscle Wasting and Weakness. Dordrecht: Springer; 2011.
Mobbs CV, Hof PR. Body Composition and Aging. Basel: S. Karger AG; 2010. https://doi.org/10.1159/isbn.978-3-8055-9522-3.
Zinner C, Sperlich B. Marathon Running: Physiology, Psychology, Nutrition and Training Aspects: Springer International Publishing; 2016. https://doi.org/10.1007/978-3-319-29728-6.
Research Article
Kenny GP, Groeller H, McGinn R, Flouris AD. Age, human performance, and physical employment standards. Appl Physiol Nutr Metab. 2016;41(6 Suppl 2):S92–S107.
Kirkendall DT, Garrett WE. The effects of aging and training on skeletal muscle. Am J Sports Med. 1998;26(4):598–602.
Garg K, Boppart MD. Influence of exercise and aging on extracellular matrix composition in the skeletal muscle stem cell niche. J Appl Physiol. 2016;121(5):1053–8.
Hunter SK, Pereira HM, Keenan KG. The aging neuromuscular system and motor performance. J Appl Physiol. 2016;121(4):982–95.
López-Lluch G, Navas P. Calorie restriction as an intervention in ageing. J Physiol. 2016;594(8):2043–60.
Hariharan N, Sussman MA. Cardiac aging – Getting to the stem of the problem. J Mol Cell Cardiol. 2015;83:32–6.
AJ LB, Hoying JB. Adaptation of the coronary microcirculation in aging. Microcirculation. 2016;23(2):157–67.
Lee CE, McArdle A, Griffiths RD. The role of hormones, cytokines and heat shock proteins during age-related muscle loss. Clin Nutr. 2007;26(5):524–34.
Hamrick MW, ME MG-L, Frechette DM. Fatty infiltration of skeletal muscle: Mechanisms and comparisons with bone marrow adiposity. Front Endocrinol (Lausanne). 2016;7:69.
Knowlton AA, Korzick DH. Estrogen and the female heart. Mol Cell Endocrinol. 2014;389(1–2):31–9.
Ma Y, Li J. Metabolic shifts during aging and pathology. Compr Physiol. 2015;5(2):667–86.
Aon MA, Bhatt N, Cortassa SC. Mitochondrial and cellular mechanisms for managing lipid excess. Front Physiol. 2014;5:282.
Demontis F, Piccirillo R, Goldberg AL, Perrimon N. Mechanisms of skeletal muscle aging: insights from Drosophila and mammalian models. Dis Model Mech. 2013;6(6):1339–52.
Hood DA, Tryon LD, Carter HN, Kim Y, Chen CC. Unravelling the mechanisms regulating muscle mitochondrial biogenesis. Biochem J. 2016;473(15):2295–314.
Carter HN, Chen CC, Hood DA. Mitochondria, muscle health, and exercise with advancing age. Physiology (Bethesda). 2015;30(3):208–23.
Hunter GR, Plaisance EP, Carter SJ, Fisher G. Why intensity is not a bad word: Optimizing health status at any age. Clin Nutr. 2017; https://doi.org/10.1016/j.clnu.2017.02.004.
Ji LL, Kang C. Role of PGC-1α in sarcopenia: Etiology and potential intervention – A mini-review. Gerontology. 2015;61(2):139–48.
Dumont NA, Bentzinger CF, Sincennes MC, Rudnicki MA. Satellite cells and skeletal muscle regeneration. Compr Physiol. 2015;5(3):1027–59.
Nguyen N, Sussman MA. Rejuvenating the senescent heart. Curr Opin Cardiol. 2015;30(3):235–9.
Cartee GD, Hepple RT, Bamman MM, Zierath JR. Exercise promotes healthy aging of skeletal muscle. Cell Metab. 2016;23(6):1034–47.
Crescenzo R, Bianco F, Mazzoli A, Giacco A, Liverini G, Iossa S. Skeletal muscle mitochondrial energetic efficiency and aging. Int J Mol Sci. 2015;16(5):10674–85.
Shadrin IY, Khodabukus A, Bursac N. Striated muscle function, regeneration, and repair. Cell Mol Life Sci. 2016;73(22):4175–202.
Acknowledgments
This work was supported in part by the Ramalingaswamy Re-entry Fellowship from the Department of Biotechnology (DBT), India, and Research Award under File No. ECR/2016/001247 by the Science and Engineering Research Board (SERB), Department of Science and Technology (DST), India to N.C.B.
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Pani, S., Bal, N.C. (2020). Aging in Muscle. In: Rath, P. (eds) Models, Molecules and Mechanisms in Biogerontology. Springer, Singapore. https://doi.org/10.1007/978-981-32-9005-1_16
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DOI: https://doi.org/10.1007/978-981-32-9005-1_16
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