Skip to main content

So-Called Fibrohistiocytic Tumors

  • Chapter
  • First Online:
  • 1467 Accesses

Abstract

Using electron microscopy, immunohistochemistry, and cytogenetics, it has come to be understood that most tumors that were initially considered to be various types of fibrohistiocytic tumors are actually not histiocytic in origin. Rather, these tumors are a diverse group of neoplasms that only appear histologically similar to fibrohistiocytic tumors. In the revised 2013 WHO classification of soft tissue sarcomas, the term “malignant fibrous histiocytoma” was removed from the “so-called fibrohistiocytic tumor” category. The so-called fibrohistiocytic tumors are composed of the following four tumors: tenosynovial giant cell tumor, deep benign fibrous histiocytoma, plexiform fibrohistiocytic tumor, and giant cell tumor of soft tissue.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   159.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  • Al-Nakshabandi NA, Ryan AG, Choudur H, Torreggiani W, Nicoloau S, Munk PL, Al-Ismail K. Pigmented villonodular synovitis. Clin Radiol. 2004;59(5):414–20. doi:10.1016/j.crad.2003.11.013.

    Article  CAS  PubMed  Google Scholar 

  • An SB, Choi JA, Chung JH, Oh JH, Kang HS. Giant cell tumor of soft tissue: a case with atypical US and MRI findings. Korean J Radiol. 2008;9(5):462–5. doi:10.3348/kjr.2008.9.5.462.

    Article  PubMed  PubMed Central  Google Scholar 

  • Boland JM, Folpe AL, Hornick JL, Grogg KL. Clusterin is expressed in normal synoviocytes and in tenosynovial giant cell tumors of localized and diffuse types: diagnostic and histogenetic implications. Am J Surg Pathol. 2009;33(8):1225–9. doi:10.1097/PAS.0b013e3181a6d86f.

  • Chung J, Namkoong S, Sim JH, Lee JS, Hong SP, Kim MH, Park BC. Deep penetrating benign fibrous histiocytoma of the foot associated with throbbing pain. Ann Dermatol. 2011;23(Suppl 2):S239–42. doi:10.5021/ad.2011.23.S2.S239.

    Article  PubMed  PubMed Central  Google Scholar 

  • de Saint Aubain Somerhausen N, van de Rijn M. Tenosynovial giant cell tumour. In: WHO classiciation of tumours of soft tissue and bone. 4th ed. Lyon: International Agency for Research on Cancer; 2013. p. 100–3.

    Google Scholar 

  • Flandry F, Hughston JC. Pigmented villonodular synovitis. J Bone Joint Surg Am. 1987;69(6):942–9.

    Article  CAS  PubMed  Google Scholar 

  • Fletcher CD. Benign fibrous histiocytoma of subcutaneous and deep soft tissue: a clinicopathologic analysis of 21 cases. Am J Surg Pathol. 1990;14(9):801–9.

    Article  CAS  PubMed  Google Scholar 

  • Gleason BC, Fletcher CD. Deep “benign” fibrous histiocytoma: clinicopathologic analysis of 69 cases of a rare tumor indicating occasional metastatic potential. Am J Surg Pathol. 2008;32(3):354–62. doi:10.1097/PAS.0b013e31813c6b85.

    Article  PubMed  Google Scholar 

  • Hughes TH, Sartoris DJ, Schweitzer ME, Resnick DL. Pigmented villonodular synovitis: MRI characteristics. Skelet Radiol. 1995;24(1):7–12.

    Article  CAS  Google Scholar 

  • Jo E, Cho ES, Kim HS, Nam W. Deep benign fibrous histiocytoma in the oral cavity: a case report. J Korean Assoc Oral Maxillofac Surg. 2015;41(5):270–2. doi:10.5125/jkaoms.2015.41.5.270.

    Article  PubMed  PubMed Central  Google Scholar 

  • Machiels F, De Maeseneer M, Chaskis C, Bourgain C, Osteaux M. Deep benign fibrous histiocytoma of the knee: CT and MR features with pathologic correlation. Eur Radiol. 1998;8(6):989–91. doi:10.1007/s003300050502.

    Article  CAS  PubMed  Google Scholar 

  • Meana Moris AR, Garcia Gonzalez P, Fuente Martin E, Gonzalez Suarez C, Moro Barrero L. Primary giant cell tumor of soft tissue: fluid-fluid levels at MRI (2010:3b). Eur Radiol. 2010;20(6):1539–43. doi:10.1007/s00330-009-1528-x.

    Article  PubMed  Google Scholar 

  • Middleton WD, Patel V, Teefey SA, Boyer MI. Giant cell tumors of the tendon sheath: analysis of sonographic findings. AJR Am J Roentgenol. 2004;183(2):337–9. doi:10.2214/ajr.183.2.1830337.

    Article  PubMed  Google Scholar 

  • Murphey MD, Rhee JH, Lewis RB, Fanburg-Smith JC, Flemming DJ, Walker EA. Pigmented villonodular synovitis: radiologic-pathologic correlation. Radiographics. 2008;28(5):1493–518. doi:10.1148/rg.285085134.

    Article  PubMed  Google Scholar 

  • O’Connell JX, Wehrli BM, Nielsen GP, Rosenberg AE. Giant cell tumors of soft tissue: a clinicopathologic study of 18 benign and malignant tumors. Am J Surg Pathol. 2000;24(3):386–95.

    Article  PubMed  Google Scholar 

  • Oliveira AM. Giant cell tumours of soft tissue. In: Fletcher CDM, Bridge JA, Hogendoorn PCW, Mertens F, editors. WHO classiciation of tumours of soft tissue and bone. 4th ed. Lyon: International Agency for Research on Cancer; 2013. p. 100–3.

    Google Scholar 

  • Oliveira AM, Dei Tos AP, Fletcher CD, Nascimento AG. Primary giant cell tumor of soft tissues: a study of 22 cases. Am J Surg Pathol. 2000;24(2):248–56.

    Article  CAS  PubMed  Google Scholar 

  • Schwartz HS, Unni KK, Pritchard DJ. Pigmented villonodular synovitis. A retrospective review of affected large joints. Clin Orthop Relat Res. 1989;247:243–55.

    Google Scholar 

  • Thomas KL, Henderson-Jackson E, Caracciolo JT. Test yourself: answer—deep benign fibrous histiocytoma. Skelet Radiol. 2015;44(8):1151–2. doi:10.1007/s00256-015-2113-9.

    Article  Google Scholar 

  • Ushijima M, Hashimoto H, Tsuneyoshi M, Enjoji M. Giant cell tumor of the tendon sheath (nodular tenosynovitis). A study of 207 cases to compare the large joint group with the common digit group. Cancer. 1986;57(4):875–84.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

Copyright information

© 2017 Springer Science+Business Media Singapore

About this chapter

Cite this chapter

Kang, H.S., Hong, S.H., Choi, JY., Yoo, H.J. (2017). So-Called Fibrohistiocytic Tumors. In: Oncologic Imaging: Soft Tissue Tumors. Springer, Singapore. https://doi.org/10.1007/978-981-287-718-5_6

Download citation

  • DOI: https://doi.org/10.1007/978-981-287-718-5_6

  • Published:

  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-287-717-8

  • Online ISBN: 978-981-287-718-5

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics