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Functional Dyspepsia

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Helicobacter pylori

Abstract

Functional dyspepsia (FD) is defined as a clinical condition in which pain arises from the gastroduodenal area in the absence of any organic, systemic, or metabolic disease that could explain the symptoms. Dyspeptic symptoms must be present for the previous 3 months with symptom onset at least 6 months before diagnosis according to the Rome III criteria. Helicobacter pylori (H. pylori) infection is considered a predisposing factor for FD, because H. pylori is known not only to induce pathologic change of the gastric mucosa but also to affect several gastrointestinal hormones. Furthermore, recent studies showed that H. pylori could influence molecular biology causing motility disorders. Unfortunately, the results are still controversial, and further studies are needed to evaluate the role of H. pylori. H. pylori eradication is suggested as one of the treatment options for FD. In countries with a high prevalence of H. pylori infection, such as Korea, H. pylori eradication might improve the symptoms of FD patients. Several meta-analyses reported that H. pylori eradication could improve symptoms in patients with FD compared to placebo; however, there are limitations, including heterogeneity of enrolled studies. Therefore, well-designed, prospective studies are required to confirm the effect of H. pylori eradication in FD.

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  1. Department of Internal Medicine, Kosin University College of Medicine, 262 Gamcheon-ro, Seo-gu, Busan, 49267, South Korea

    Sung Eun Kim

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  1. Seoul National University, Bundang Hospital, Seongnam-si, Gyeonggi-do, Korea (Republic of)

    Nayoung Kim

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Kim, S.E. (2016). Functional Dyspepsia. In: Kim, N. (eds) Helicobacter pylori. Springer, Singapore. https://doi.org/10.1007/978-981-287-706-2_18

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  • DOI: https://doi.org/10.1007/978-981-287-706-2_18

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