Diversified Insulin-Associated Beta-Behavioral and Endogenously Triggered Exposed Symptoms (DIABETES) Model of Diabetes in India

  • P. Raja RajeswariEmail author
  • Chandrasekaran Subramaniam
  • Allam Appa Rao
Part of the SpringerBriefs in Applied Sciences and Technology book series (BRIEFSAPPLSCIENCES)


The objective of the paper was to propose a diversified insulin-associated beta-behavioral and endogenously triggered exposed symptoms (DIABETES) model due to multiple factors so as to suggest medical remedies to improve the avoidance of diabetes disease. The various causes and their chances toward the most common diabetes effects including deaths in the nation are modeled as an diversified insulin association. The regional, social, biological and cultural aspects of the Indian community are considered to model the diabetes that of different categories. The performance and the correctness of the model are determined by considering the heterogeneity due to different factors that are specified as proposed IAB-ETES process algebra. The model-driven approach needs restricted operations on the variables to supplement any health care information system. The individual human responsibility and societal awareness along with the health regulation acts can minimize the vulnerability of the disease if the information technology for biological system complies with the enforcement acts of the developing nation.


Diversification Association Endogenous Exposed Cultural Causality Causes and outcomes 


  1. 1.
    Whiting D, Unwin N, Roglic G (2010) Diabetes: equity and social determinants. In: Blas E, Kurup A (eds) Equity, social determinants and public health programmes. World Health Organization, pp 77–94Google Scholar
  2. 2.
    Goldstein J, Jacoby E, del Aguila R et al (2005) Poverty is a predictor of non-communicable disease among adults in Peruvian cities. Prev Med 41(3–4):800–806CrossRefGoogle Scholar
  3. 3.
    Wild S, Roglic G, Green A et al (2004) Global prevalence of diabetes. Diabetes Care 27:1047–1053CrossRefGoogle Scholar
  4. 4.
    Shobhana R, Rao PR, Lavanya A et al (2000) Expenditure on health care incurred by diabetic subjects in a developing country–a study from southern India. Diabetes Res Clin Pract 48(1):37–42CrossRefGoogle Scholar
  5. 5.
    Hawkes C (2005) The role of foreign direct investment in the nutrition transition. Public Health Nutr 8(4):357–365CrossRefGoogle Scholar
  6. 6.
    Knowler WC, Connor EB, Fowler SE et al (2002) Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. The New England J Med 346(6):393–403CrossRefGoogle Scholar
  7. 7.
    Lindström J, Louheranta A, Mannelin M et al (2003) The Finnish Diabetes prevention study (dps): lifestyle intervention and 3-year results on diet and physical activity. Diabetes Care 26(12):3230–3236CrossRefGoogle Scholar
  8. 8.
    Gillespie D (2008) Sweet poison: why sugar makes you fat. p 118, ISBN 978-0-670-07247-7Google Scholar
  9. 9.
    Keys A (1970) Coronary heart disease in seven countries. American Heart Association, New YorkGoogle Scholar
  10. 10.
    Uemura K, Pisa Z (1988) Trends in cardiovascular disease mortality in industrialized countries since 1950. World Health Stat Q 41:155–178Google Scholar
  11. 11.
    Sarti C, Rastenyte D, Cepaitis Z, Tuomilehto J (2000) International trends in mortality from stroke 1968 to 1994. Stroke 31:1588–1601CrossRefGoogle Scholar
  12. 12.
    The Merck Manual of Medical Information (2003) Diabetes mellitus. p 962, ISBN 978-0-7434-7733-8Google Scholar
  13. 13.
    Cerasi E, Luft R (1967) The plasma insulin response to glucose infusion in healthy subjects and in diabetes mellitus. Acta Endocrinol (Copeh.) 55:278–304Google Scholar
  14. 14.
    Hosker JP, Rudenski AS, Burnett MA, Matthews DR, Turner RC (1989) Similar reduction of first- and second-phase B-cell responses at three different glucose levels in type II diabetes and the effect of gliclazide therapy. Metabolism 38:767–772CrossRefGoogle Scholar
  15. 15.
    Butler AE, Janson J, Bonner-Weir S, Ritzel R, Rizza RA, Butler PC (2003) Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes. Diabetes 52:102–110CrossRefGoogle Scholar
  16. 16.
    Froguel P, Vaxillaire M, Sun F, Velho G, Zouali H, Butel MO, Lesage S, Vionnet N, Clément K, Fougerousse F et al (1992) Close linkage of glucokinase locus on chromosome 7p to early-onset non-insulin-dependent diabetes mellitus. Nature 356:162–164CrossRefGoogle Scholar
  17. 17.
    Supale S, Li N, Brun T, Maechler P (2012) Mitochondrial dysfunction in pancreatic β cells. Trends Endocrinol Metab 23:477–487CrossRefGoogle Scholar
  18. 18.
    Robertson RP (2004) Chronic oxidative stress as a central mechanism for glucose toxicity in pancreatic islet beta cells in diabetes. J Biol Chem 279:42351–42354CrossRefGoogle Scholar
  19. 19.
    Jonas JC, Sharma A, Hasenkamp W, Ilkova H, Patanè G, Laybutt R, Bonner-Weir S, Weir GC (1999) Chronic hyperglycemia triggers loss of pancreatic beta cell differentiation in an animal model of diabetes. J Biol Chem 274:14112–14121CrossRefGoogle Scholar
  20. 20.
    Fittante A (2007) Prevention’s the sugar solution. p 264, ISBN 1-59486-693-7Google Scholar
  21. 21.
  22. 22.
  23. 23.
    Kuulasmaa K, Tunstall-Pedoe H, Dobson A et al (2000) Estimation of contribution of changes in classic risk factors to trends in coronary-event rates across the WHO MONICA Project populations. Lancet 355:675–687. (CrossRefMedlineWeb of Science
  24. 24.
    Eriksson KF, Lindgarde F (1991) Prevention of type 2 (non-insulin-dependent) diabetes mellitus by diet and physical exercise. The 6-year Malmö feasibility study. Diabetologia 34:891–898. (CrossRefMedlineWeb of Science
  25. 25.
    Bloom garden ZT (2004) Type 2 diabetes in the young: the evolving epidemic. Diabetes Care 27:998–1010CrossRefGoogle Scholar
  26. 26.
    Fagot-Campagna A, Pettitt DJ, Engelgau MM et al (2000) Type 2 diabetes among North American children and adolescents: an epidemiologic review and a public health perspective. J Pediatr 136:664–672CrossRefGoogle Scholar

Copyright information

© The Author(s) 2015

Authors and Affiliations

  • P. Raja Rajeswari
    • 1
    Email author
  • Chandrasekaran Subramaniam
    • 2
  • Allam Appa Rao
    • 3
  1. 1.Sri Venkateswara Hindu College of EngineeringMachilipatnamIndia
  2. 2.EASA Engineering CollegeAnna UniversityCoimbatoreIndia
  3. 3.C.R.Rao Advanced Institute of Mathematics, Statistics and Computer Science, University of Hyderabad CampusHyderabadIndia

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