Abstract
This chapter looks into the hierarchical structures of peptide sequences and hydrogels constructed with physical solution assembly in an attempt to discuss the fundamental properties of peptide hydrogels and the molecular foundations. Peptide hydrogels are great candidates in the ever-growing field of biological and medical applications due to their ease of synthesis and customizable molecular and material features. The natural cytocompatibility and degradability of peptides make peptide hydrogels great candidates for cell encapsulation and drug delivery. There is immense potential in using new peptide molecules to make new hydrogel materials with both designed properties as well as unanticipated, excellent properties.
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References
Bromley, E.H.C., Channon, K.J., King, P.J.S., et al.: Assembly pathway of a designed alpha-helical protein fiber. Biophys. J. 98, 1668–1676 (2010). doi:10.1016/j.bpj.2009.12.4309
Ruoslahti, E.: RGD and other recognition sequences for integrins. Annu. Rev. Cell Dev. Biol. 12, 697–715 (1996). doi:10.1146/annurev.cellbio.12.1.697
Nilsson, B.L., Soellner, M.B., Raines, R.T.: Chemical synthesis of proteins. Annu. Rev. Biophys. Biomol. Struct. 34, 91 (2005)
Hersel, U., Dahmen, C., Kessler, H.: RGD modified polymers: biomaterials for stimulated cell adhesion and beyond. Biomaterials 24, 4385–4415 (2003)
Iha, R.K., Wooley, K.L., Nyström, A.M., et al.: Applications of orthogonal “click” chemistries in the synthesis of functional soft materials. Chem. Rev. 109, 5620–5686 (2009)
Collier, J.H., Segura, T.: Evolving the use of peptides as components of biomaterials. Biomaterials 32, 4198–4204 (2011). doi:10.1016/j.biomaterials.2011.02.030
DeForest, C.A., Sims, E.A., Anseth, K.S.: Peptide-functionalized click hydrogels with independently tunable mechanics and chemical functionality for 3D cell culture. Chem. Mater. 22, 4783–4790 (2010). doi:10.1021/cm101391y
Ruoslahti, E.: Integrins. J. Clin. Invest. 87, 1–5 (1991). doi:10.1172/JCI114957
DeForest, C.A., Polizzotti, B.D., Anseth, K.S.: Sequential click reactions for synthesizing and patterning three-dimensional cell microenvironments. Nat. Mater. 8, 659–664 (2009). doi:10.1038/nmat2473
Ulijn, R.V., Smith, A.M.: Designing peptide based nanomaterials. Chem. Soc. Rev. 37, 664–675 (2008)
Kyle, S., Aggeli, A., Ingham, E., McPherson, M.J.: Production of self-assembling biomaterials for tissue engineering. Trends Biotechnol. 27, 423–433 (2009). doi:10.1016/j.tibtech.2009.04.002
Woolfson, D.N., Mahmoud, Z.N.: More than just bare scaffolds: towards multi-component and decorated fibrous biomaterials. Chem. Soc. Rev. 39, 3464–3479 (2010). doi:10.1039/c0cs00032a
Smith, A.M., Banwell, E.F., Edwards, W.R., et al.: Engineering increased stability into self-assembled protein fibers. Adv. Funct. Mater. 16, 1022–1030 (2006). doi:10.1002/adfm.200500568
Schneider, J., Pochan, D., Ozbas, B., et al.: Responsive hydrogels from the intramolecular folding and self-assembly of a designed peptide. J. Am. Chem. Soc. 124, 15030–15037 (2002). doi:10.1021/ja027993g
Bowerman, C.J., Nilsson, B.L.: A reductive trigger for peptide self-assembly and hydrogelation. J. Am. Chem. Soc. 132, 9526–9527 (2010). doi:10.1021/ja1025535
Kopecek, J., Yang, J.: Smart self-assembled hybrid hydrogel biomaterials. Angew. Chem. Int. Ed. 51, 7396–7417 (2012). doi:10.1002/anie.201201040
Ryan, D.M., Nilsson, B.L.: Self-assembled amino acids and dipeptides as noncovalent hydrogels for tissue engineering. Polym. Chem. 3, 18–33 (2011). doi:10.1039/c1py00335f
Nicolai, T., Durand, D.: Controlled food protein aggregation for new functionality. Curr. Opin. Colloid Interface Sci. 18, 249–256 (2013). doi:10.1016/j.cocis.2013.03.001
Kopecek, J., Yang, J.: Peptide-directed self-assembly of hydrogels. Acta Biomater. 5, 805–816 (2009). doi:10.1016/j.actbio.2008.10.001
Zhang, Y., Gu, H., Yang, Z., Xu, B.: Supramolecular hydrogels respond to ligand–receptor interaction. J. Am. Chem. Soc. 125, 13680–13681 (2003). doi:10.1021/ja036817k
Shu, J.Y., Panganiban, B., Xu, T.: Peptide–polymer conjugates: from fundamental science to application. Annu. Rev. Phys. Chem. 64, 631–657 (2013)
Bowerman, C.J., Liyanage, W., Federation, A.J., Nilsson, B.L.: Tuning beta-sheet peptide self-assembly and hydrogelation behavior by modification of sequence hydrophobicity and aromaticity. Biomacromolecules 12, 2735–2745 (2011). doi:10.1021/bm200510k
Li, J., Gao, Y., Kuang, Y., et al.: Dephosphorylation of d-peptide derivatives to form biofunctional, supramolecular nanofibers/hydrogels and their potential applications for intracellular imaging and intratumoral chemotherapy. J. Am. Chem. Soc. 135, 9907–9914 (2013). doi:10.1021/ja404215g
Kim, M., Tang, S., Olsen, B.D.: Physics of engineered protein hydrogels. J. Polym. Sci. B Polym. Phys. 51, 587–601 (2013). doi:10.1002/polb.23270
Khakshoor, O., Nowick, J.S.: Artificial beta-sheets: chemical models of beta-sheets. Curr. Opin. Chem. Biol. 12, 722–729 (2008). doi:10.1016/j.cbpa.2008.08.009
Das, A.K., Collins, R., Ulijn, R.V.: Exploiting enzymatic (reversed) hydrolysis in directed self-assembly of peptide nanostructures. Small 4, 279–287 (2008)
Ozbas, B., Rajagopal, K., Schneider, J., Pochan, D.: Semiflexible chain networks formed via self-assembly of β-hairpin molecules. Phys. Rev. Lett. 93, 268106 (2004). doi:10.1103/PhysRevLett.93.268106
Ozbas, B., Kretsinger, J., Rajagopal, K., et al.: Salt-triggered peptide folding and consequent self-assembly into hydrogels with tunable modulus. Macromolecules 37, 7331–7337 (2004)
Bakota, E.L., Aulisa, L., Galler, K.M., Hartgerink, J.D.: Enzymatic cross-linking of a nanofibrous peptide hydrogel. Biomacromolecules 12, 82–87 (2011). doi:10.1021/bm1010195
Olsen, B.D.: Engineering materials from proteins. AIChE J. 59, 3558–3568 (2013). doi:10.1002/aic.14223
Jung, J.P., Nagaraj, A.K., Fox, E.K., et al.: Co-assembling peptides as defined matrices for endothelial cells. Biomaterials 30, 2400–2410 (2009)
DiMarco, R.L., Heilshorn, S.C.: Multifunctional materials through modular protein engineering. Adv. Mater. 24, 3923–3940 (2012). doi:10.1002/adma.201200051
Estroff, L.A., Hamilton, A.D.: Water gelation by small organic molecules. Chem. Rev. 104, 1201–1218 (2004)
Bromley, E.H.C., Channon, K., Moutevelis, E., Woolfson, D.N.: Peptide and protein building blocks for synthetic biology: from programming biomolecules to self-organized biomolecular systems. ACS Chem. Biol. 3, 38–50 (2008). doi:10.1021/cb700249v
Kyle, S., Aggeli, A., Ingham, E., McPherson, M.J.: Recombinant self-assembling peptides as biomaterials for tissue engineering. Biomaterials 31, 9395–9405 (2010). doi:10.1016/j.biomaterials.2010.08.051
Woolfson, D.N.: Building fibrous biomaterials from alpha-helical and collagen-like coiled-coil peptides. Pept. Sci. 94, 118–127 (2010). doi:10.1002/bip.21345
Guvendiren, M., Lu, H.D., Burdick, J.A.: Shear-thinning hydrogels for biomedical applications. Soft Matter 8, 260–272 (2011). doi:10.1039/c1sm06513k
Yan, C., Pochan, D.J.: Rheological properties of peptide-based hydrogels for biomedical and other applications. Chem. Soc. Rev. 39, 3528–3540 (2010)
Smith, T.J., Khatcheressian, J., Lyman, G.H., et al.: 2006 update of recommendations for the use of white blood cell growth factors: an evidence-based clinical practice guideline. J. Clin. Oncol. 24, 3187–3205 (2006)
Jayawarna, V., Richardson, S.M., Hirst, A.R., et al.: Introducing chemical functionality in Fmoc-peptide gels for cell culture. Acta Biomater. 5, 934–943 (2009). doi:10.1016/j.actbio.2009.01.006
Olsen, B.D., Kornfield, J.A., Tirrell, D.A.: Yielding behavior in injectable hydrogels from telechelic proteins. Macromolecules 43, 9094–9099 (2010). doi:10.1021/ma101434a
Adams, D.J., Butler, M.F., Frith, W.J., et al.: A new method for maintaining homogeneity during liquid–hydrogel transitions using low molecular weight hydrogelators. Soft Matter 5, 1856 (2009). doi:10.1039/b901556f
Bakota, E.L., Wang, Y., Danesh, F.R., Hartgerink, J.D.: Injectable multidomain peptide nanofiber hydrogel as a delivery agent for stem cell secretome. Biomacromolecules 12, 1651–1657 (2011)
Saiani, A., Mohammed, A., Frielinghaus, H., et al.: Self-assembly and gelation properties of alpha-helix versus beta-sheet forming peptides. Soft Matter 5, 193–202 (2009). doi:10.1039/b811288f
Macaya, D., Spector, M.: Injectable hydrogel materials for spinal cord regeneration: a review. Biomed. Mater. 7, 012001 (2012). doi:10.1088/1748-6041/7/1/012001
Doose, S., Neuweiler, H., Barsch, H., Sauer, M.: Probing polyproline structure and dynamics by photoinduced electron transfer provides evidence for deviations from a regular polyproline type II helix. Proc. Natl. Acad. Sci. 104, 17400–17405 (2007). doi:10.1073/pnas.0705605104
Yang, Z., Gu, H., Fu, D., et al.: Enzymatic formation of supramolecular hydrogels. Adv. Mater. 16, 1440–1444 (2004). doi:10.1002/adma.200400340
Raeburn, J., Zamith Cardoso, A., Adams, D.J.: The importance of the self-assembly process to control mechanical properties of low molecular weight hydrogels. Chem. Soc. Rev. 42, 5143–5156 (2013). doi:10.1039/c3cs60030k
Yucel, T., Micklitsch, C.M., Schneider, J.P., Pochan, D.J.: Direct observation of early-time hydrogelation in beta-hairpin peptide self-assembly. Macromolecules 41, 5763–5772 (2008). doi:10.1021/ma702840q
Aulisa, L., Dong, H., Hartgerink, J.D.: Self-assembly of multidomain peptides: sequence variation allows control over cross-linking and viscoelasticity. Biomacromolecules 10, 2694–2698 (2009). doi:10.1021/bm900634x
Branco, M.C., Pochan, D.J., Wagner, N.J., Schneider, J.P.: Macromolecular diffusion and release from self-assembled beta-hairpin peptide hydrogels. Biomaterials 30, 1339–1347 (2009). doi:10.1016/j.biomaterials.2008.11.019
Lin, B.F., Megley, K.A., Viswanathan, N., et al.: pH-responsive branched peptide amphiphile hydrogel designed for applications in regenerative medicine with potential as injectable tissue scaffolds. J. Mater. Chem. 22, 19447 (2012). doi:10.1039/c2jm31745a
Tagalakis, A.D., Saraiva, L., McCarthy, D., et al.: Comparison of nanocomplexes with branched and linear peptides for SiRNA delivery. Biomacromolecules 14, 761–770 (2013)
Dong, H., Dube, N., Shu, J.Y., et al.: Long-circulating 15 nm micelles based on amphiphilic 3-helix peptide–PEG conjugates. ACS Nano 6, 5320–5329 (2012). doi:10.1021/nn301142r
Cui, H., Webber, M.J., Stupp, S.I.: Self-assembly of peptide amphiphiles: from molecules to nanostructures to biomaterials. Biopolymers 94, 1–18 (2010). doi:10.1002/bip.21328
Gosal, W.S., Clark, A.H., Ross-Murphy, S.B.: Fibrillar β-lactoglobulin gels: part 1. Fibril formation and structure. Biomacromolecules 5, 2408–2419 (2004). doi:10.1021/bm049659d
Liu, T.-Y., Hussein, W.M., Jia, Z., et al.: Self-adjuvanting polymer–peptide conjugates as therapeutic vaccine candidates against cervical cancer. Biomacromolecules 14, 2798–2806 (2013). doi:10.1021/bm400626w
Gosal, W.S., Clark, A.H., Pudney, P.D., Ross-Murphy, S.B.: Novel amyloid fibrillar networks derived from a globular protein: β-lactoglobulin. Langmuir 18, 7174–7181 (2002)
Lin, Y.-A., Ou, Y.-C., Cheetham, A.G., Cui, H.: Supramolecular polymers formed by ABC miktoarm star peptides. ACS Macro Lett 2, 1088–1094 (2013). doi:10.1021/mz400535g
Kavanagh, G.M., Clark, A.H., Ross-Murphy, S.B.: Heat-induced gelation of globular proteins. Part 5. Creep behaviour of β-lactoglobulin gels. Rheol. Acta 41, 276–284 (2002). doi:10.1007/s00397-001-0220-0
Hamley, I.W.: Self-assembly of amphiphilic peptides. Soft Matter 7, 4122–4138 (2011). doi:10.1039/c0sm01218a
Kroes-Nijboer, A., Venema, P., Linden, E.V.D.: Fibrillar structures in food. Food Funct. 3, 221–227 (2012). doi:10.1039/c1fo10163c
Lee, K., Mooney, D.: Hydrogels for tissue engineering. Chem. Rev. 101, 1869–1879 (2001). doi:10.1021/cr000108x
Bowerman, C.J., Nilsson, B.L.: Review self-assembly of amphipathic β-sheet peptides: Insights and applications. Pept. Sci. 98, 169–184 (2012). doi:10.1002/bip.22058
Cheng, R.P., Gellman, S.H., DeGrado, W.F.: β-Peptides: from structure to function. Chem. Rev. 101, 3219–3232 (2001)
Totosaus, A., Montejano, J.G., Salazar, J.A., Guerrero, I.: A review of physical and chemical protein-gel induction. Int. J. Food Sci. Technol. 37, 589–601 (2002). doi:10.1046/j.1365-2621.2002.00623.x
Hauser, C.A., Zhang, S.: Designer self-assembling peptide nanofiber biological materials. Chem. Soc. Rev. 39, 2780–2790 (2010). doi:10.1039/b921448h
Li, Y., Rodrigues, J., Tomás, H.: Injectable and biodegradable hydrogels: gelation, biodegradation and biomedical applications. Chem. Soc. Rev. 41, 2193–2221 (2012). doi:10.1039/c1cs15203c
Heilshorn, S.C., Liu, J.C., Tirrell, D.A.: Cell-binding domain context affects cell behavior on engineered proteins. Biomacromolecules 6, 318–323 (2005). doi:10.1021/bm049627q
Ngo, J.T., Tirrell, D.A.: Noncanonical amino acids in the interrogation of cellular protein synthesis. Acc. Chem. Res. 44, 677–685 (2011). doi:10.1021/ar200144y
Gauthier, M.A., Klok, H.-A.: Peptide/protein–polymer conjugates: synthetic strategies and design concepts. Chem. Commun. 2591–2611 (2008). doi:10.1039/b719689j
Yan, C., Altunbas, A., Yucel, T., et al.: Injectable solid hydrogel: mechanism of shear-thinning and immediate recovery of injectable β-hairpin peptide hydrogels. Soft Matter 6, 5143–5156 (2010). doi:10.1039/c0sm00642d
Haines-Butterick, L., Rajagopal, K., Branco, M., et al.: Controlling hydrogelation kinetics by peptide design for three-dimensional encapsulation and injectable delivery of cells. Proc. Natl. Acad. Sci. U.S.A. 104, 7791–7796 (2007). doi:10.1073/pnas.0701980104
Moss, J.A.: Unit 18.7: Guide for resin and linker selection in solid‐phase peptide synthesis. Curr. Protoc. Prot. Sci. 1–19 (2005)
Barany, G., Albericio, F.: Three-dimensional orthogonal protection scheme for solid-phase peptide synthesis under mild conditions. J. Am. Chem. Soc. 107, 4936–4942 (1985)
Naik, R.R., Stringer, S.J., Agarwal, G., et al.: Biomimetic synthesis and patterning of silver nanoparticles. Nat. Mater. 1, 169–172 (2002). doi:10.1038/nmat758
Akdim, B., Pachter, R., Kim, S.S., et al.: Electronic properties of a graphene device with peptide adsorption: insight from simulation. ACS Appl. Mater. Interfaces 5, 7470–7477 (2013). doi:10.1021/am401731c
Dickerson, M.B., Sandhage, K.H., Naik, R.R.: Protein- and peptide-directed syntheses of inorganic materials. Chem. Rev. 108, 4935–4978 (2008)
Helen, W., de Leonardis, P., Ulijn, R.V., et al.: Mechanosensitive peptide gelation: mode of agitation controls mechanical properties and nano-scale morphology. Soft Matter 7, 1732 (2011). doi:10.1039/c0sm00649a
Morris, K.L., Chen, L., Raeburn, J., et al.: Chemically programmed self-sorting of gelator networks. Nat. Commun. 4, 1480 (2013)
Ramachandran, S., Taraban, M.B., Trewhella, J., et al.: Effect of temperature during assembly on the structure and mechanical properties of peptide-based materials. Biomacromolecules 11, 1502–1506 (2010). doi:10.1021/bm100138m
Feng, Y., Taraban, M., Yu, Y.B.: The effect of ionic strength on the mechanical, structural and transport properties of peptide hydrogels. Soft Matter 8, 11723–11731 (2012). doi:10.1039/c2sm26572a
Kim, C.A., Berg, J.M.: Thermodynamic β-sheet propensities measured using a zinc-finger host peptide. Nature 362, 267–270 (1993). doi:10.1038/362267a0
Jung, J.P., Gasiorowski, J.Z., Collier, J.H.: Fibrillar peptide gels in biotechnology and biomedicine. Biopolymers 94, 49–59 (2010). doi:10.1002/bip.21326
Nagy, K.J., Giano, M.C., Jin, A., et al.: Enhanced mechanical rigidity of hydrogels formed from enantiomeric peptide assemblies. J. Am. Chem. Soc. 133, 14975–14977 (2011). doi:10.1021/ja206742m
Whisstock, J.C., Bottomley, S.P.: Molecular gymnastics: serpin structure, folding and misfolding. Curr. Opin. Struct. Biol. 16, 761–768 (2006). doi:10.1016/j.sbi.2006.10.005
Nagarkar, R.P., Hule, R.A., Pochan, D.J., Schneider, J.P.: Domain swapping in materials design. Biopolymers 94, 141–155 (2010). doi:10.1002/bip.21332
Rajagopal, K., Lamm, M.S., Haines-Butterick, L.A., et al.: Tuning the pH responsiveness of beta-hairpin peptide folding, self-assembly, and hydrogel material formation. Biomacromolecules 10, 2619–2625 (2009). doi:10.1021/bm900544e
Freire, F., Almeida, A.M., Fisk, J.D., et al.: Impact of strand length on the stability of parallel-beta-sheet secondary structure. Angew. Chem. Int. Ed. 50, 8735–8738 (2011). doi:10.1002/anie.201102986
Apostolovic, B., Danial, M., Klok, H.-A.: Coiled coils: attractive protein folding motifs for the fabrication of self-assembled, responsive and bioactive materials. Chem. Soc. Rev. 39, 3541–3575 (2010). doi:10.1039/b914339b
Moutevelis, E., Woolfson, D.N.: A periodic table of coiled-coil protein structures. J. Mol. Biol. 385, 726–732 (2009). doi:10.1016/j.jmb.2008.11.028
Marsden, H.R., Kros, A.: Self-assembly of coiled coils in synthetic biology: inspiration and progress. Angew. Chem. Int. Ed. 49, 2988–3005 (2010). doi:10.1002/anie.200904943
Jing, P., Rudra, J.S., Herr, A.B., Collier, J.H.: Self-assembling peptide–polymer hydrogels designed from the coiled coil region of fibrin. Biomacromolecules 9, 2438–2446 (2008)
Hule, R.A., Nagarkar, R.P., Altunbas, A., et al.: Correlations between structure, material properties and bioproperties in self-assembled β-hairpin peptide hydrogels. Faraday Discuss. 139, 251–264 (2008)
Branco, M.C., Nettesheim, F., Pochan, D.J., et al.: Fast dynamics of semiflexible chain networks of self-assembled peptides. Biomacromolecules 10, 1374–1380 (2009)
Altunbas, A., Lee, S.J., Rajasekaran, S.A., et al.: Encapsulation of curcumin in self-assembling peptide hydrogels as injectable drug delivery vehicles. Biomaterials 32, 5906–5914 (2011). doi:10.1016/j.biomaterials.2011.04.069
Yan, C., Mackay, M.E., Czymmek, K., et al.: Injectable solid peptide hydrogel as a cell carrier: effects of shear flow on hydrogels and cell payload. Langmuir 28, 6076–6087 (2012). doi:10.1021/la2041746
Anderson, S.B., Lin, C.-C., Kuntzler, D.V., Anseth, K.S.: The performance of human mesenchymal stem cells encapsulated in cell-degradable polymer–peptide hydrogels. Biomaterials 32, 3564–3574 (2011)
Tian, Y.F., Devgun, J.M., Collier, J.H.: Fibrillized peptide microgels for cell encapsulation and 3D cell culture. Soft Matter 7, 6005–6011 (2011)
Jabbari, E.: Bioconjugation of hydrogels for tissue engineering. Curr. Opin. Biotechnol. 22, 655–660 (2011)
Haines-Butterick, L.A., Salick, D.A., Pochan, D.J., Schneider, J.P.: In vitro assessment of the pro-inflammatory potential of β-hairpin peptide hydrogels. Biomaterials 29, 4164–4169 (2008). doi:10.1016/j.biomaterials.2008.07.009
Rudra, J.S., Mishra, S., Chong, A.S., et al.: Self-assembled peptide nanofibers raising durable antibody responses against a malaria epitope. Biomaterials 33, 6476–6484 (2012)
Koutsopoulos, S., Unsworth, L.D., Nagai, Y., Zhang, S.: Controlled release of functional proteins through designer self-assembling peptide nanofiber hydrogel scaffold. Proc. Natl. Acad. Sci. 106, 4623–4628 (2009). doi:10.1073/pnas.0807506106
Branco, M.C., Pochan, D.J., Wagner, N.J., Schneider, J.P.: The effect of protein structure on their controlled release from an injectable peptide hydrogel. Biomaterials 31, 9527–9534 (2010)
Weber, L.M., Lopez, C.G., Anseth, K.S.: Effects of PEG hydrogel crosslinking density on protein diffusion and encapsulated islet survival and function. J. Biomed. Mater. Res. 90A, 720–729 (2009). doi:10.1002/jbm.a.32134
Burdick, J.A., Anseth, K.S.: Photoencapsulation of osteoblasts in injectable RGD-modified PEG hydrogels for bone tissue engineering. Biomaterials 23, 4315–4323 (2002)
Van Tomme, S.R., Storm, G., Hennink, W.E.: In situ gelling hydrogels for pharmaceutical and biomedical applications. Int. J. Pharm. 355, 1–18 (2008)
Collier, J.H., Hu, B.H., Ruberti, J.W., et al.: Thermally and photochemically triggered self-assembly of peptide hydrogels. J. Am. Chem. Soc. 123, 9463–9464 (2001). doi:10.1021/ja011535a
Collier, J.H., Messersmith, P.B.: Enzymatic modification of self-assembled peptide structures with tissue transglutaminase. Bioconjug. Chem. 14, 748–755 (2003). doi:10.1021/bc034017t
Engler, A.J., Sen, S., Sweeney, H.L., Discher, D.E.: Matrix elasticity directs stem cell lineage specification. Cell 126, 677–689 (2006). doi:10.1016/j.cell.2006.06.044
Kim, I.L., Mauck, R.L., Burdick, J.A.: Hydrogel design for cartilage tissue engineering: a case study with hyaluronic acid. Biomaterials 32, 8771–8782 (2011)
Silva, D., Natalello, A., Sanii, B., et al.: Synthesis and characterization of designed BMHP1-derived self-assembling peptides for tissue engineering applications. Nanoscale 5, 704–718 (2013)
Webber, M.J., Tongers, J., Renault, M.-A., et al.: Development of bioactive peptide amphiphiles for therapeutic cell delivery. Acta Biomater. 6, 3–11 (2010). doi:10.1016/j.actbio.2009.07.031
Collier, J.H., Rudra, J.S., Gasiorowski, J.Z., Jung, J.P.: Multi-component extracellular matrices based on peptide self-assembly. Chem. Soc. Rev. 39, 3413–3424 (2010). doi:10.1039/b914337h
Eliyahu-Gross, S., Bitton, R.: Environmentally responsive hydrogels with dynamically tunable properties as extracellular matrix mimetic. Rev. Chem. Eng. 29, 159–168 (2013)
Romano, N.H., Sengupta, D., Chung, C., Heilshorn, S.C.: Protein-engineered biomaterials: nanoscale mimics of the extracellular matrix. Biochim. Biophys. Acta 1810, 339–349 (2011). doi:10.1016/j.bbagen.2010.07.005
Matson, J.B., Stupp, S.I.: Self-assembling peptide scaffolds for regenerative medicine. Chem. Commun. 48, 26 (2011). doi:10.1039/c1cc15551b
Jayawarna, V., Smith, A., Gough, J.E., Ulijn, R.V.: Three-dimensional cell culture of chondrocytes on modified di-phenylalanine scaffolds. Biochem. Soc. Trans. 35, 535–537 (2007)
Giano, M.C., Pochan, D.J., Schneider, J.P.: Controlled biodegradation of self-assembling β-hairpin peptide hydrogels by proteolysis with matrix metalloproteinase-13. Biomaterials 32, 6471–6477 (2011). doi:10.1016/j.biomaterials.2011.05.052
Galler, K.M., Hartgerink, J.D., Cavender, A.C., et al.: A customized self-assembling peptide hydrogel for dental pulp tissue engineering. Tissue Eng. Part A 18, 176–184 (2012). doi:10.1089/ten.tea.2011.0222
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Sun, J.E.P., Pochan, D. (2015). Peptidic Hydrogels. In: Loh, X. (eds) In-Situ Gelling Polymers. Series in BioEngineering. Springer, Singapore. https://doi.org/10.1007/978-981-287-152-7_6
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