Association of BDNF Levels and Muscoskeletal Problems in Type 2 Diabetes
Brain Derived neurotrophic factor (BDNF) is very well reported in development of neurons and it plays major role in memory and interpretation. It is evident that BDNF is involved in maintaining the equilibrium of body weight and glucose homeostasis mechanism. Out of 96 Subjects included in this study Plasma BDNF level was found low in the patients with Type 2 Diabetes. We didn’t find positive indications wrt association of BDNF G196A (Val66Met) polymorphism in diabetes or obesity. Type 2 Diabetic patients with the complaint of Joint pains were found to have even lower Plasma BDNF levels as compared to the diabetic patients without any Neurological problems or joint pains. Worsening BDNF Levels may be an alarming factor for type 2 diabetic patients with respect to development of Neurological disorders.
KeywordsBDNF levels in diabetic patients BDNF Diabetes type 2
Funding and Support
This Research was solely funded by Department of Science and Technology, Government of India under IRHPA Scheme vide Lr No. IR/SO/LU/03/2008/1.
Conflict of Interest
Authors didn’t have any conflict of interest in this Research.
- 2.Bath KG, Lee FS (2010) Neurotrophic factor control of adult SVZ neurogenesis. Dev Neurobiol 70(5):339–349 Special Issue: Trophic factors: 50 years of growth Google Scholar
- 4.Matthews VB, Åström M-B, Chan MHS, Bruce CR, Prelovsek O, Åkerström T, Yfanti C, Broholm C, Mortensen OH, Penkowa M, Hojman P, Zankari A, Watt MJ, Pedersen BK, Febbraio MA (2009) Brain derived neutrophic factor is produced by skeletal muscle cells in response to contraction and enhances fat oxidation via activation of AMPK. Diabetologia 52:1409–1418CrossRefGoogle Scholar
- 7.Rozen Steve, Skaletsky Helen J (2000) Primer3 on the www for general users and for biologist programmers. In: Krawetz S, Misener S (eds) Bioinformatics methods and protocols: methods in molecular biology. Humana Press, Totowa, pp 365–386Google Scholar
- 12.Li Y, Rowland C, Tacey K et al (2005) The BDNF Val66Met polymorphism is not associated with late onset Alzheimer’s disease in three case-control samples. Mol Psychiatry 10(809–810):26Google Scholar
- 13.Surtees PG, Wainwright NWJ, Willis-Owen SAG et al (2007) No association between the BDNF Val66Met polymorphism and mood status in a non-clinical community sample of 7389 older adults. J Psychiatr Res 41(5):404–409 Google Scholar