Association of BDNF Levels and Muscoskeletal Problems in Type 2 Diabetes

  • Allam Appa Rao
  • Amit Kumar
  • Surendra Babu
  • Anuradha Parihar
  • Subha Senkhula
Chapter
Part of the SpringerBriefs in Applied Sciences and Technology book series (BRIEFSAPPLSCIENCES)

Abstract

Brain Derived neurotrophic factor (BDNF) is very well reported in development of neurons and it plays major role in memory and interpretation. It is evident that BDNF is involved in maintaining the equilibrium of body weight and glucose homeostasis mechanism. Out of 96 Subjects included in this study Plasma BDNF level was found low in the patients with Type 2 Diabetes. We didn’t find positive indications wrt association of BDNF G196A (Val66Met) polymorphism in diabetes or obesity. Type 2 Diabetic patients with the complaint of Joint pains were found to have even lower Plasma BDNF levels as compared to the diabetic patients without any Neurological problems or joint pains. Worsening BDNF Levels may be an alarming factor for type 2 diabetic patients with respect to development of Neurological disorders.

Keywords

BDNF levels in diabetic patients BDNF Diabetes type 2 

Notes

Funding and Support

This Research was solely funded by Department of Science and Technology, Government of India under IRHPA Scheme vide Lr No. IR/SO/LU/03/2008/1.

Conflict of Interest

Authors didn’t have any conflict of interest in this Research.

References

  1. 1.
    Molteni R, Barnard RJ, Ying Z et al (2002) A high-fat, refined sugar diet reduces hippocampal brain-derived neurotrophic factor, neuronal plasticity, and learning. Neuroscience 112:803–814CrossRefGoogle Scholar
  2. 2.
    Bath KG, Lee FS (2010) Neurotrophic factor control of adult SVZ neurogenesis. Dev Neurobiol 70(5):339–349 Special Issue: Trophic factors: 50 years of growth Google Scholar
  3. 3.
    Mattson MP, Maudsley S, Martin B (2004) BDNF and 5-HT: a dynamic duo in age-related neuronal plasticity and neurodegenerative disorders. Trends Neurosci 27:589–594CrossRefGoogle Scholar
  4. 4.
    Matthews VB, Åström M-B, Chan MHS, Bruce CR, Prelovsek O, Åkerström T, Yfanti C, Broholm C, Mortensen OH, Penkowa M, Hojman P, Zankari A, Watt MJ, Pedersen BK, Febbraio MA (2009) Brain derived neutrophic factor is produced by skeletal muscle cells in response to contraction and enhances fat oxidation via activation of AMPK. Diabetologia 52:1409–1418CrossRefGoogle Scholar
  5. 5.
    Kernie Steven G, Liebl Daniel J, Parada Luis F (2000) BDNF regulates eating behavior and locomotor activity in mice. EMBO J 19:1290–1300CrossRefGoogle Scholar
  6. 6.
    Causing CG, Gloster A, Aloyz R, Bamji SX, Chang E, Fawcett J, Kutchel G, Miler FD (1997) Synaptic innervation density is regulated by neuronderived, BDNF. Neuron 18:257–267CrossRefGoogle Scholar
  7. 7.
    Rozen Steve, Skaletsky Helen J (2000) Primer3 on the www for general users and for biologist programmers. In: Krawetz S, Misener S (eds) Bioinformatics methods and protocols: methods in molecular biology. Humana Press, Totowa, pp 365–386Google Scholar
  8. 8.
    Ono M, Ichihara J, Nonomura T et al (1997) Brain-derived neurotrophic factor reduces blood glucose level in obese diabetic mice but not in normal mice. Biochem Biophys Res Commun 238:633–637CrossRefGoogle Scholar
  9. 9.
    Krabbe KS, Nielsen AR, Krogh-Madsen R et al (2007) Brain-derived neurotrophic factor (BDNF) and type 2 diabetes. Diabetologia 50(2):431–438CrossRefGoogle Scholar
  10. 10.
    Figurov A, Pozzo-Miller LD, Olafsson P, Wang T, Lu B (1996) Regulation of synaptic responses to high-frequency stimulation and LTP by neurotropins in the hippocampus. Nature 381:706–709CrossRefGoogle Scholar
  11. 11.
    Lommatzsch M, Zingler D, Schuhbaeck K et al (2005) The impact of age, weight and gender on BDNF levels in human platelets and plasma. Neurobiol Aging 26(1):115–123CrossRefGoogle Scholar
  12. 12.
    Li Y, Rowland C, Tacey K et al (2005) The BDNF Val66Met polymorphism is not associated with late onset Alzheimer’s disease in three case-control samples. Mol Psychiatry 10(809–810):26Google Scholar
  13. 13.
    Surtees PG, Wainwright NWJ, Willis-Owen SAG et al (2007) No association between the BDNF Val66Met polymorphism and mood status in a non-clinical community sample of 7389 older adults. J Psychiatr Res 41(5):404–409 Google Scholar
  14. 14.
    Matsushita S, Arai H, Matsui T et al (2005) Brain-derived neurotrophic factor gene polymorphisms and Alzheimer’s disease. J Neural Transm 112:703–711CrossRefGoogle Scholar
  15. 15.
    Maggio R, Riva M, Vaglini F, Fornai F, Racagni G, Corsini GU (1997) Striatal increase of neurotrophic factors as a mechanism of nicotine protection in experimental Parkinsonism. J Neural Transm 104:1113–1123CrossRefGoogle Scholar
  16. 16.
    Kim RP, Edelman SV, Kim DD (2001) Musculoskeletal complications of diabetes. Clin Diab 19(3):132–135CrossRefGoogle Scholar

Copyright information

© The Author(s) 2015

Authors and Affiliations

  • Allam Appa Rao
    • 1
  • Amit Kumar
    • 2
  • Surendra Babu
    • 2
    • 3
  • Anuradha Parihar
    • 2
  • Subha Senkhula
    • 4
  1. 1.Jawaharlal Nehru Technological UniversityKakinadaIndia
  2. 2.BioAxis DNA Research Centre (P) LimitedHyderabadIndia
  3. 3.Andhra UniversityVisakhapatnamIndia
  4. 4.Jawaharlal Nehru Technological UniversityVijayanagaramIndia

Personalised recommendations