Association of BDNF Levels and Muscoskeletal Problems in Type 2 Diabetes

  • Allam Appa RaoEmail author
  • Amit Kumar
  • Surendra Babu
  • Anuradha Parihar
  • Subha Senkhula
Part of the SpringerBriefs in Applied Sciences and Technology book series (BRIEFSAPPLSCIENCES)


Brain Derived neurotrophic factor (BDNF) is very well reported in development of neurons and it plays major role in memory and interpretation. It is evident that BDNF is involved in maintaining the equilibrium of body weight and glucose homeostasis mechanism. Out of 96 Subjects included in this study Plasma BDNF level was found low in the patients with Type 2 Diabetes. We didn’t find positive indications wrt association of BDNF G196A (Val66Met) polymorphism in diabetes or obesity. Type 2 Diabetic patients with the complaint of Joint pains were found to have even lower Plasma BDNF levels as compared to the diabetic patients without any Neurological problems or joint pains. Worsening BDNF Levels may be an alarming factor for type 2 diabetic patients with respect to development of Neurological disorders.


BDNF levels in diabetic patients BDNF Diabetes type 2 


Funding and Support

This Research was solely funded by Department of Science and Technology, Government of India under IRHPA Scheme vide Lr No. IR/SO/LU/03/2008/1.

Conflict of Interest

Authors didn’t have any conflict of interest in this Research.


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Copyright information

© The Author(s) 2015

Authors and Affiliations

  • Allam Appa Rao
    • 1
    Email author
  • Amit Kumar
    • 2
  • Surendra Babu
    • 2
    • 3
  • Anuradha Parihar
    • 2
  • Subha Senkhula
    • 4
  1. 1.Jawaharlal Nehru Technological UniversityKakinadaIndia
  2. 2.BioAxis DNA Research Centre (P) LimitedHyderabadIndia
  3. 3.Andhra UniversityVisakhapatnamIndia
  4. 4.Jawaharlal Nehru Technological UniversityVijayanagaramIndia

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