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Investigation of Chitosan/Metal and Metal Oxide Nanocomposites as a New Strategy for Enhanced Anti-Biofilm Efficacy with Reduced Toxicity

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Chitosan Nanocomposites

Part of the book series: Biological and Medical Physics, Biomedical Engineering ((BIOMEDICAL))

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Abstract

Worldwide, biofilm producing bacteria are the most challenging and careful concern, responsible for variety of infections in human every year. The clumping of sessile bacterial cells attached to each other in the inherent surfaces and embedded in an extracellular polymeric matrix is referred as a biofilm. Biofilm producing bacteria and their mode of dissemination are more resistance to conventional antibiotics and immune response killing. Researchers are more struggled and investigated alternative anti-biofilm drugs with novel strategies to combat antibiotic resistant biofilm producing bacteria. In recent years, metal and metal oxide nanoparticles are widely used nanomaterials with promising applications in medical field and offer novel approaches to tackle different kind of pathogens. On contrary, increased concentrations of nanomaterial with considerable level of toxicity against various infections in medical field are great challenge. To avoid this problem, nano-formulation demonstrates hopeful choice to succeed improved bioavailability and targeted drug delivery. Chitosan (Cs) is a natural polymer derived from derivatives of chitin which is extensively used in biomedical research due to the complete degradation and biocompatibility. Metal nanoparticles (M NPs) and metal oxide nanoparticles (MO NPs) have wide surface area and frequently utilized in biomedical research because of their inert biological properties. In recent years, the preparation of Cs/metal nanocomposites (Cs/M NCs)and Cs/metal oxide nanocomposites (Cs/MO NCs) are safer, chemically stable, and have excellent bioavailability and biocompatibility with minimized toxicities against various infectious bacteria. Hence, the main objective of this work is to discuss the alternative way to increase the bioavailability of M NPs and MO NPs in the presence of Cs to treat biofilm producing bacteria with minimized toxicity.

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Acknowledgements

Dr. G. Rajivgandhi and Dr. Franck Quero acknowledge the financial support from ANID-FONDECYT (Chile) under the Postdoctoral Fellowship No. 3220019.

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  1. Laboratorio de Nanocelulosa y Biomateriales, Departamento de Ingeniería Química, Biotecnología y Materiales, Universidad de Chile, Avenida Beauchef-851, Santiago, Chile

    Govindan Rajivgandhi, Muthuchamy Maruthupandy & Franck Quero

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  1. Govindan Rajivgandhi
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  2. Muthuchamy Maruthupandy
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  3. Franck Quero
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Correspondence to Muthuchamy Maruthupandy or Franck Quero .

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  1. Department of Chemistry, Veer Surendra Sai University of Technology, Burla, Sambalpur, Odisha, India

    Sarat Kumar Swain

  2. Department of Chemistry, Veer Surendra Sai University of Technology, Burla, Sambalpur, Odisha, India

    Anuradha Biswal

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© 2023 The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.

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Rajivgandhi, G., Maruthupandy, M., Quero, F. (2023). Investigation of Chitosan/Metal and Metal Oxide Nanocomposites as a New Strategy for Enhanced Anti-Biofilm Efficacy with Reduced Toxicity. In: Swain, S.K., Biswal, A. (eds) Chitosan Nanocomposites. Biological and Medical Physics, Biomedical Engineering. Springer, Singapore. https://doi.org/10.1007/978-981-19-9646-7_15

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