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Glossopharyngeal Neuralgia Focusing on Microvascular Decompression

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Trigeminal Neuralgia
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Abstract

Glossopharyngeal neuralgia (GPN), albeit rare, poses a significant challenge to physicians. The first symptomatic description appeared in a case report in 1910 on a patient who had been diagnosed with tic douloureux for 6 years; the authors suggested that the symptoms were attributed to a certain irritation of the ninth and twelfth cranial nerves [1]. The term GPN was first used by Harris to describe paroxysms of pain in the back of the tongue, throat, etc., in 1921 [2]. The incidence of GPN is roughly estimated as 1% of TN [3].

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References

  1. White JC, Sweet WH. Pain and the neurosurgeon: a forty-year experience. CC Thomas; 1969.

    Google Scholar 

  2. Harris W. Persistent pain in lesions of the peripheral and central nervous system. Br Med J. 1921;2(3178):896.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Sarlani E, Grace EG, Balciunas BA, Schwartz AH. Trigeminal neuralgia in a patient with multiple sclerosis and chronic inflammatory demyelinating polyneuropathy. J Am Dent Assoc. 2005;136(4):469–76.

    Article  PubMed  Google Scholar 

  4. Arnold M. Headache classification committee of the international headache society (IHS) the international classification of headache disorders. Cephalalgia. 2018;38(1):1–211.

    Article  Google Scholar 

  5. Rozen TD. Trigeminal neuralgia and glossopharyngeal neuralgia. Neurol Clin. 2004;22(1):185–206.

    Article  PubMed  Google Scholar 

  6. Chen J, Sindou M. Vago-glossopharyngeal neuralgia: a literature review of neurosurgical experience. Acta Neurochir. 2015;157(2):311–21.

    Article  PubMed  Google Scholar 

  7. Rushton JG, Stevens JC, Miller RH. Glossopharyngeal (vagoglossopharyngeal) neuralgia a study of 217 cases. Arch Neurol. 1981;38(4):201–5.

    Article  CAS  PubMed  Google Scholar 

  8. Kim MK, Park JS, Ahn YH. Microvascular decompression for glossopharyngeal neuralgia: clinical analyses of 30 cases. J Korean Neurosurg Soc. 2017;60(6):738.

    Article  PubMed  PubMed Central  Google Scholar 

  9. Singleton AO. Glossopharyngeal neuralgia and its surgical relief. Ann Surg. 1926;83(3):338.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Dandy WE. Glossopharyngeal neuralgia (tic douloureux): its diagnosis and treatment. Arch Surg. 1927;15(2):198–214.

    Article  Google Scholar 

  11. Laha RK, Jannetta PJ. Glossopharyngeal neuralgia. J Neurosurg. 1977;47(3):316–20.

    Article  CAS  PubMed  Google Scholar 

  12. Stieber VW, Bourland JD, Ellis TL. Glossopharyngeal neuralgia treated with gamma knife surgery: treatment outcome and failure analysis: case report. J Neurosurg. 2005;102(Spl_Suppl):155–7.

    PubMed  Google Scholar 

  13. Pearce J. Glossopharyngeal neuralgia. Eur Neurol. 2006;55(1):49–52.

    Article  CAS  PubMed  Google Scholar 

  14. Tubbs RS, Shoja MM, Loukas M. Anatomy of the glossopharyngeal nerve. In: Nerves and Nerve Injuries, vol. 1. Elsevier; 2015. p. 371–83.

    Google Scholar 

  15. Wang C, Kundaria S, Fernandez-Miranda J, Duvvuri U. A description of the anatomy of the glossopharyngeal nerve as encountered in transoral surgery. Laryngoscope. 2016;126(9):2010–5.

    Article  PubMed  Google Scholar 

  16. Ajayi N, Lazarus L, Satyapal K. Trigeminal cave and ganglion: an anatomical review. Int J Morphol. 2013;31(4):1444–8.

    Article  Google Scholar 

  17. Kakizawa Y, Seguchi T, Kodama K, et al. Anatomical study of the trigeminal and facial cranial nerves with the aid of 3.0-tesla magnetic resonance imaging. J Neurosurg. 2008;108(3):483–90.

    Article  PubMed  Google Scholar 

  18. Wang M, Chae R, Shehata J, et al. Comparative analysis of surgical exposure and freedom between the subtonsillar, endoscope-assisted subtonsillar, and far-lateral approaches to the lower clivus: a cadaveric study. J Clin Neurosci. 2020;72:412–9.

    Article  CAS  PubMed  Google Scholar 

  19. Peris-Celda M, Oushy S, Perry A, et al. Nervus intermedius and the surgical management of geniculate neuralgia. J Neurosurg. 2018;131(2):343–51.

    Article  PubMed  Google Scholar 

  20. Koratkar H, Parashar V, Koratkar S. A review of neuropathic pain conditions affecting teeth. Gen Dent. 2010;58(5):436–41. quiz 442

    PubMed  Google Scholar 

  21. Blumenfeld A, Nikolskaya G. Glossopharyngeal neuralgia. Curr Pain Headache Rep. 2013;17(7):343.

    Article  PubMed  Google Scholar 

  22. Patel A, Kassam A, Horowitz M, Chang Y-F. Microvascular decompression in the management of glossopharyngeal neuralgia: analysis of 217 cases. Neurosurgery. 2002;50(4):705–11.

    Article  PubMed  Google Scholar 

  23. Manzoni G, Torelli P. Epidemiology of typical and atypical craniofacial neuralgias. Neurol Sci. 2005;26(2):s65–7.

    Article  PubMed  Google Scholar 

  24. Yang K-H, Na J-H, Kong D-S, Park K. Combined hyperactive dysfunction syndrome of the cranial nerves. J Korean Neurosurg Soc. 2009;46(4):351.

    Article  PubMed  PubMed Central  Google Scholar 

  25. Kong Y, Heyman A, Entman ML, Mcintosh HD. Glossopharyngeal neuralgia associated with bradycardia, syncope, and seizures. Circulation. 1964;30(1):109–13.

    Article  CAS  PubMed  Google Scholar 

  26. Barbash GI, Keren G, Korczyn AD, et al. Mechanisms of syncope in glossopharyngeal neuralgia. Electroencephalogr Clin Neurophysiol. 1986;63(3):231–5.

    Article  CAS  PubMed  Google Scholar 

  27. Sibilla L, Agarwal N. Cranial Nerve IX: glossopharyngeal. In: Neuroimaging: anatomy meets function. Springer; 2018. p. 207–10.

    Google Scholar 

  28. Fromm GH. Clinical pharmacology of drugs used to treat head and face pain. Neurol Clin. 1990;8(1):143–51.

    Article  CAS  PubMed  Google Scholar 

  29. Moretti R, Torre P, Antonello R, Bava A, Cazzato G. Gabapentin treatment of glossopharyngeal neuralgia: a follow-up of four years of a single case. Eur J Pain. 2002;6(5):403–7.

    Article  PubMed  Google Scholar 

  30. Hardy DG, Rhoton AL. Microsurgical relationships of the superior cerebellar artery and the trigeminal nerve. J Neurosurg. 1978;49(5):669–78.

    Article  CAS  PubMed  Google Scholar 

  31. Janetta P. Microsurgical exploration and decompression of the facial nerve in hemifacial spasm. Curr Top Surg Res. 1970;2:217–20.

    Google Scholar 

  32. Park JS, Ahn YH. Glossopharyngeal Neuralgia. J Korean Neurosurg Soc. 2022;66(1):12–23.

    Article  PubMed  PubMed Central  Google Scholar 

  33. Sampson JH, Grossi PM, Asaoka K, Fukushima T. Microvascular decompression for glossopharyngeal neuralgia: long-term effectiveness and complication avoidance. Neurosurgery. 2004;54(4):884–90.

    Article  PubMed  Google Scholar 

  34. Kawashima M, Matsushima T, Inoue T, Mineta T, Masuoka J, Hirakawa N. Microvascular decompression for glossopharyngeal neuralgia through the transcondylar fossa (supracondylar transjugular tubercle) approach. Operative. Neurosurgery. 2010;66(suppl_2):ons275–80.

    Google Scholar 

  35. Lee SH, Park JS, Ahn YH. Bioglue-coated teflon sling technique in microvascular decompression for hemifacial spasm involving the vertebral artery. J Korean Neurosurg Soc. 2016;59(5):505.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  36. Matsushima T, Huynh-Le P, Miyazono M. Trigeminal neuralgia caused by venous compression. Neurosurgery. 2004;55(2):334–9.

    Article  PubMed  Google Scholar 

  37. Linskey ME, Ratanatharathorn V, Peñagaricano J. A prospective cohort study of microvascular decompression and gamma knife surgery in patients with trigeminal neuralgia. J Neurosurg. 2008;109(Supplement):160–72.

    Article  PubMed  Google Scholar 

  38. Breeze R, Ignelzi RJ. Microvascular decompression for trigeminal neuralgia: results with special reference to the late recurrence rate. J Neurosurg. 1982;57(4):487–90.

    Article  CAS  PubMed  Google Scholar 

  39. Park JS, Lee S, Park S-K, Lee J-A, Park K. Facial motor evoked potential with paired transcranial magnetic stimulation: prognostic value following microvascular decompression for hemifacial spasm. J Neurosurg. 2018;131(6):1780–7.

    Article  PubMed  Google Scholar 

  40. Ozenci M, Karaoguz R, Conkbayir C, Altin T, Kanpolat Y. Glossopharyngeal neuralgia with cardiac syncope treated by glossopharyngeal rhizotomy and microvascular decompression. Europace. 2003;5(2):149–52.

    Article  CAS  PubMed  Google Scholar 

  41. Bohm E, Strang R. Glossopharyngeal neuralgia. Brain. 1962;85(2):371–88.

    Article  Google Scholar 

  42. Rey-Dios R, Cohen-Gadol AA. Current neurosurgical management of glossopharyngeal neuralgia and technical nuances for microvascular decompression surgery. Neurosurg Focus. 2013;34(3):E8.

    Article  PubMed  Google Scholar 

  43. Ma Y, Li Y-f, Wang Q-c, Wang B, Huang H-t. Neurosurgical treatment of glossopharyngeal neuralgia: analysis of 103 cases. J Neurosurg. 2016;124(4):1088–92.

    Article  PubMed  Google Scholar 

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Correspondence to Young Hwan Ahn .

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The Majority of contents in this article are based on our recent publication in JKNS (Journal of Korean Neurosurgical Society). However, all the figures that are used for this chapter are original and not bound to copyright restrictions.

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Park, J.S., Ahn, Y.H. (2023). Glossopharyngeal Neuralgia Focusing on Microvascular Decompression. In: Park, K., Cho, K.R. (eds) Trigeminal Neuralgia. Springer, Singapore. https://doi.org/10.1007/978-981-19-9171-4_25

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  • DOI: https://doi.org/10.1007/978-981-19-9171-4_25

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