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Therapeutic Effects of Corticosteroids for Critical and Severe COVID-19 Patients

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Data Mining and Big Data (DMBD 2022)

Part of the book series: Communications in Computer and Information Science ((CCIS,volume 1745))

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Abstract

The rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has led to an unprecedented public health, economic, and social crisis worldwide. Since no therapeutic treatment is yet available to effectively clear the virus and terminate transmission, supportive therapy is the primary clinical approach for coronavirus disease (COVID-19). The role of corticosteroids as one of the main means of anti-inflammatory adjuvants in the treatment of COVID-19 is controversial. Here, we retrospectively evaluated the therapeutic effects of corticosteroids by comparing clinical data of patients treated with or without a corticosteroids therapy at different severity levels. Kaplan-Meier curves shows that therapy with methylprednisolone and cortico-steroids increases the risk of death in patients with critical COVID-19 pneumonia. For patients in the critical group, the risk of death was slightly higher in males receiving corticosteroids therapy, while hypertension and trauma history reduced the hazard ratio.

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Author information

Authors and Affiliations

  1. Lishui Institute of Hangzhou Dianzi University, Hangzhou, Zhejiang, China

    Yuhan Gao & Yaoqi Sun

  2. Department of Automation, Hangzhou Dianzi University, Hangzhou, Zhejiang, China

    Yuhan Gao, Yaoqi Sun & Jiyong Zhang

  3. Tsinghua Shenzhen International Graduate School, Shenzhen, Guangdong, China

    Jinlan Bi & Shengying Wang

  4. Sir Run Run Shaw Hospital, Hangzhou, Zhejiang, China

    Mang Xiao

Authors
  1. Yuhan Gao
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  2. Yaoqi Sun
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  3. Jinlan Bi
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  4. Shengying Wang
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  5. Jiyong Zhang
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  6. Mang Xiao
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Corresponding author

Correspondence to Mang Xiao .

Editor information

Editors and Affiliations

  1. Peking University, Beijing, China

    Ying Tan

  2. Southern University of Science and Technology, Shenzhen, China

    Yuhui Shi

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© 2022 The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.

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Gao, Y., Sun, Y., Bi, J., Wang, S., Zhang, J., Xiao, M. (2022). Therapeutic Effects of Corticosteroids for Critical and Severe COVID-19 Patients. In: Tan, Y., Shi, Y. (eds) Data Mining and Big Data. DMBD 2022. Communications in Computer and Information Science, vol 1745. Springer, Singapore. https://doi.org/10.1007/978-981-19-8991-9_19

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  • DOI: https://doi.org/10.1007/978-981-19-8991-9_19

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  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-19-8990-2

  • Online ISBN: 978-981-19-8991-9

  • eBook Packages: Computer ScienceComputer Science (R0)

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