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The Role of Telomerase Activators in Antiaging Strategies and their Clinical Potential

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Emerging Anti-Aging Strategies

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Abstract

Recent studies have focused on telomere shortening for the prevention of cellular aging and diseases related to aging. Re-extension of shortened telomeres is achieved by various naturally or synthetically produced telomerase activators. Naturally, every cell division can induce telomere shortening, as well as factors such as food, lifestyle, stress, and past diseases that affect the shortening of telomeres. Age-related diseases such as cardiovascular, cognitive, neurodegenerative diseases, and cancer are seen as a result of aging of the cell due to telomere shortening and thus aging of the organism. Telomerase activators play a very important role in the prevention of age-related conditions and diseases. This review focuses on telomeric aging, the molecular mechanism of action of telomerase activators, and the clinical importance of these activators by compiling studies in the context of increasing human lifespan and healthy aging. In this perspective, this study examined the telomerase activators produced both naturally and synthetically, revealing the signaling pathways used by these activators and their clinically relevant concentrations. It will also guide future research that can be conducted to determine the function of telomerase activation in the treatment of human aging-related diseases.

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Authors and Affiliations

  1. Faculty of Science, Department of Biology, Istanbul University, Istanbul, Turkey

    Yasemin Aydin & Banu Orta-Yilmaz

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  1. Yasemin Aydin
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  2. Banu Orta-Yilmaz
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Correspondence to Yasemin Aydin .

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  1. Department of Biochemistry, University of Allahabad, Allahabad, Uttar Pradesh, India

    Syed Ibrahim Rizvi

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Aydin, Y., Orta-Yilmaz, B. (2023). The Role of Telomerase Activators in Antiaging Strategies and their Clinical Potential. In: Rizvi, S.I. (eds) Emerging Anti-Aging Strategies. Springer, Singapore. https://doi.org/10.1007/978-981-19-7443-4_12

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