Abstract
Photoimmunotherapy induces an anti-tumor immune response by cytotoxic T-lymphocytes (CTLs) activated by neoantigens released from cancer tissues by fever and singlet oxygen generation when a photosensitive agent accumulated in cancer cells is irradiated with laser light in the near-infrared fluorescent region (650–900 nm). The use of near-infrared fluorescence probes has the potential to overcome the problems of “insufficient selectivity to tumors” and “photosensitivity due to side effects” of current commercially available fluorescence probes (Photofrin, Rezafirin, Visudyne, etc.), and advantages suitable for observation and treatment deep inside the body. In fact, a phase III clinical trial of an antibody-drug conjugate using IR-700 as a near-infrared fluorescent dye (ASP-1929) is already underway for head and neck cancer, and is expected to open up a new future in cancer treatment.
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Tamura, Y., Suganami, A., Okamoto, Y. (2023). Application to Therapy (2): Photoimmunotherapy Using a Near-Infrared Fluorescent Probe. In: Ishizawa, T. (eds) Fluorescence-Guided Surgery. Springer, Singapore. https://doi.org/10.1007/978-981-19-7372-7_34
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DOI: https://doi.org/10.1007/978-981-19-7372-7_34
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