Abstract
Peritoneal dissemination as well as hematogenous and lymphatic metastasis is an important clinical factor in the treatment of gastrointestinal cancers. In particular, tiny nodules of peritoneal metastasis are difficult to detect with current diagnostic imaging modalities such as CT and MRI. Therefore, staging laparoscopy is often indicated prior to making a decision for the treatment strategy in cases of advanced gastric cancer and pancreatic cancer with a high risk of peritoneal dissemination [1]. While staging laparoscopy is minimally invasive and has a high positive diagnosis rate of 89–100%, the insufficient false-negative rate (5–17.2%) [2–4] remains a problem in this strategy. We need a higher sensitive diagnostic method for peritoneal dissemination.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Stell DA, Carter CR, Stewart I, et al. Prospective comparison of laparoscopy, ultrasonography and computed tomography in staging gastric cancer. Br J Surg. 1996;83:1260–2.
Tsuchida K, Yoshikawa T, Tsuburaya A, et al. Indications for staging laparoscopy in clinical T4M0 gastric cancer. World J Surg. 2011;35:2703–9.
Song KY, Kim JJ, Kim SN, et al. Staging laparoscopy for advanced gastric cancer: is it also useful for a group which has an aggressive surgical strategy? World J Surg. 2015;39:2742–7.
Miki Y, Tokunaga M, Tanizawa Y, et al. Staging laparoscopy for patients with cM0, type 4, and large type3 gastric cancer. World J Surg. 2015;39:2742–7.
Hayashi M, Fukuhara H, Inoue K, et al. The effect of iron ion on the specificity of photodynamic therapy with 5-aminolevulinic acid. PLoS One. 2015;10:e 0122351.
Hagiya Y, Endo Y, Yonemura Y, et al. Pivotal roles of peptide transporter PEPT1 and ATP-binding cassette (ABC) transporter ABCG2 in 5-aminolevulinic acid (ALA)-based photocyto-toxicity of gastric cancer cells in vitro. Photodiagnosis Hotodyn Ther. 2012;9:204–14.
Gibson SL, Cupriks DJ, Havens JJ, et al. A regulatory role for porphobilinogen deaminase (PBGD) in 5-aminolaevulinic acid (5-ALA)-induced photosensitization? Br J Cancer. 1998;77:235–42.
Ohgari Y, Miyata Y, Chau TT, et al. Mechanisms involved in delta-aminolevulinic acid (ALA)-induced photosensitivity of tumor cells: relation of ferrochelatase and uptake of ALA to the accumulation of protoporphyrin. Biochem Pharmacol. 2005;71:42–9.
Kishi K, Fujiwara Y, Yano M, et al. Diagnostic laparoscopy with 5-aminolevulinic- acid-mediated photodynamic diagnosis enhances the detection of peritoneal micrometastases in advanced gastric cancer. Oncology. 2014;87:257–65.
Inoue K, Anai S, Fujimoto K, et al. Oral 5-aminolevulinic acid mediated photodynamic diagnosis using fluorescence cystoscopy for non-muscle- invasive bladder cancer: a randomized, double-blind, multicenter phase II/III study. Photodiagnosis Photodyn Ther. 2015;12:193–200.
Ushimaru Y, Fujiwara Y, Kishi K, et al. Prognostic significance of basing treatment strategy on the result of photodynamic diagnosis in advanced gastric cancer. Ann Surg Oncol. 2017;24:983–9.
Kishi K, Fujiwara Y, Yano M, et al. Usefulness of diagnostic laparoscopy with 5-aminolevulinic acid (ALA)-mediated photodynamic diagnosis for the detection of peritoneal micrometastasis in advanced gastric cancer after chemotherapy. Surg Today. 2016;46:1427–34.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2023 The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.
About this chapter
Cite this chapter
Takahashi, T., Kurokawa, Y., Yamasaki, M., Eguchi, H., Doki, Y. (2023). Gastric Cancer (Primary Tumor, Peritoneal Dissemination). In: Ishizawa, T. (eds) Fluorescence-Guided Surgery. Springer, Singapore. https://doi.org/10.1007/978-981-19-7372-7_16
Download citation
DOI: https://doi.org/10.1007/978-981-19-7372-7_16
Published:
Publisher Name: Springer, Singapore
Print ISBN: 978-981-19-7371-0
Online ISBN: 978-981-19-7372-7
eBook Packages: MedicineMedicine (R0)