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Case 47. A 2-Month-Old Infant with Fever, Progressive Skin Rash and Eosinophilia: Drug-Induced Fever and Skin Rash in Children

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Further Reading

  • Kardaun SH, Sekula P, Valeyrie-Allanore L, et al. Drug reaction with eosinophilia and systemic symptoms (DRESS): an original multisystem adverse drug reaction. Results from the prospective RegiSCAR study. Br J Dermatol 2013;169:1071-80.

    Article  CAS  PubMed  Google Scholar 

  • Afiouni R, Zeinaty P, Kechichian E, et al. Pediatric drug reaction with eosinophilia and systemic symptoms: A systematic review of the literature, with a focus on relapsing cases. Pediatr Dermatol 2021;38:125-31.

    Article  PubMed  Google Scholar 

  • Ann Allergy Asthma Immunol. 2021;127(6):674-81. https://doi.org/10.1016/j.anai.2021.08.012.

  • Kim GY, Anderson KR, Davis DMR, Hand JL, Tollefson MM. Drug reaction with eosinophilia and systemic symptoms (DRESS) in the pediatric population: A systematic review of the literature. J Am Acad Dermatol 2020;83:1323-30.

    Article  CAS  PubMed  Google Scholar 

  • Miyagawa F, Asada H. Current Perspective Regarding the Immunopathogenesis of Drug-Induced Hypersensitivity Syndrome/Drug Reaction with Eosinophilia and Systemic Symptoms (DIHS/DRESS). Int J Mol Sci 2021;22:2147.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Copaescu A, Gibson A, Li Y, Trubiano JA, Phillips EJ. An Updated Review of the Diagnostic Methods in Delayed Drug Hypersensitivity. Front Pharmacol 2020;11:573573.

    Article  CAS  PubMed  Google Scholar 

  • Rive CM, Bourke J, Phillips EJ. Testing for drug hypersensitivity syndromes. Clin Biochem Rev. 2013;34:15-38.

    PubMed  PubMed Central  Google Scholar 

  • Teraki Y, Fukuda T. Skin-Homing IL-13-Producing T Cells Expand in the Circulation of Patients with Drug Rash with Eosinophilia and Systemic Symptoms. Dermatology 2017;233:242-9.

    Article  CAS  PubMed  Google Scholar 

  • Husain Z, Reddy BY, Schwartz RA. DRESS syndrome: Part II. Management and therapeutics. J Am Acad Dermatol 2013;68:709.e701-709; quiz 718-720.

    Article  Google Scholar 

  • Lin YF, Yang CH, Sindy H, et al. Severe cutaneous adverse reactions related to systemic antibiotics. Clin Infect Dis 2014;58:1377-85.

    Article  CAS  PubMed  Google Scholar 

  • Chiou CC, Yang LC, Hung SI, et al. Clinicopathological features and prognosis of drug rash with eosinophilia and systemic symptoms: a study of 30 cases in Taiwan. J Eur Acad Dermatol Venereol 2008;22:1044-9.

    Article  PubMed  Google Scholar 

  • Nguyen E, Yanes D, Imadojemu S, Kroshinsky D. Evaluation of Cyclosporine for the Treatment of DRESS Syndrome. JAMA Dermatol 2020;156:704-6.

    Article  PubMed  PubMed Central  Google Scholar 

  • Kim D, Kobayashi T, Voisin B, et al. Targeted therapy guided by single-cell transcriptomic analysis in drug-induced hypersensitivity syndrome: a case report. Nat Med. 2020;26(2):236-243.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Eshki M, Allanore L, Musette P, et al. Twelve-year analysis of severe cases of drug reaction with eosinophilia and systemic symptoms: a cause of unpredictable multiorgan failure. Arch Dermatol 2009;145:67-72.

    Article  PubMed  Google Scholar 

  • Chen YC, Chang CY, Cho YT, Chiu HC, Chu CY. Long-term sequelae of drug reaction with eosinophilia and systemic symptoms: a retrospective cohort study from Taiwan. J Am Acad Dermatol 2013;68:459-65.

    Article  PubMed  Google Scholar 

  • Su H-J, Chen C-B, Yeh T-Y, Chung W-H. Successful treatment of corticosteroid-dependent drug reaction with eosinophilia and systemic symptoms with cyclosporine. Ann Allergy Asthma Immunol. 2021;127(6):674–681. https://doi.org/10.1016/j.anai.2021.08.012.

    Article  PubMed  Google Scholar 

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Chen, CB., Yen, H., Chung, WH. (2023). Case 47. A 2-Month-Old Infant with Fever, Progressive Skin Rash and Eosinophilia: Drug-Induced Fever and Skin Rash in Children. In: Huang, YC., Lee, PI., Chen, PY. (eds) Paediatric Infectious Diseases. Springer, Singapore. https://doi.org/10.1007/978-981-19-7276-8_47

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  • DOI: https://doi.org/10.1007/978-981-19-7276-8_47

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