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Split Liver Transplantation

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Pediatric Solid Organ Transplantation

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Abstract

How to get a new liver when you are 2 years old?

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References

  1. Starzl TE, Marchioro TL, Vonkaulla KN, Hermann G, Brittain RS, Waddell WR. Homotransplantation of the liver in humans. Surg Gynecol Obstet. 1963;117:659–76.

    CAS  PubMed  PubMed Central  Google Scholar 

  2. Bismuth H, Houssin D. Reduced-sized orthotopic liver graft in hepatic transplantation in children. Surgery. 1984;95(3):367–70.

    CAS  PubMed  Google Scholar 

  3. Broelsch CE, Emond JC, Thistlethwaite JR, Whitington PF, Zucker AR, Baker AL, et al. Liver transplantation, including the concept of reduced-size liver transplants in children. Ann Surg. 1988;208(4):410–20.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Pichlmayr R, Ringe B, Gubernatis G, Hauss J, Bunzendahl H. Transplantation of a donor liver to 2 recipients (splitting transplantation)—a new method in the further development of segmental liver transplantation. Langenbecks Arch Chir. 1988;373(2):127–30.

    Article  CAS  PubMed  Google Scholar 

  5. Hackl C, Schmidt KM, Süsal C, Döhler B, Zidek M, Schlitt HJ. Split liver transplantation: current developments. World J Gastroenterol. 2018;24(47):5312–21.

    Article  PubMed  PubMed Central  Google Scholar 

  6. Agence de la biomédecine [Internet]. [cited 2021 Apr 14]. https://rams.agence-biomedecine.fr/organes

  7. [No title] [Internet]. [cited 2021 Apr 14]. https://www.agence-biomedecine.fr/IMG/pdf/v25guide-regles-de-repartition.pdf

  8. Hsu EK, Shaffer ML, Gao L, Sonnenday C, Volk ML, Bucuvalas J, et al. Analysis of liver offers to pediatric candidates on the transplant wait list. Gastroenterology. 2017;153(4):988–95.

    Article  PubMed  Google Scholar 

  9. Battula NR, Platto M, Anbarasan R, Perera MTPR, Ong E, Roll GR, et al. Intention to split policy: a successful strategy in a combined pediatric and adult liver transplant center. Ann Surg. 2017;265(5):1009–15.

    Article  PubMed  Google Scholar 

  10. Angelico R, Trapani S, Spada M, Colledan M, de Ville de Goyet J, Salizzoni M, et al. A national mandatory-split liver policy: a report from the Italian experience. Am J Transplant. 2019;19(7):2029–43.

    Article  PubMed  Google Scholar 

  11. Jadlowiec CC, Taner T. Liver transplantation: current status and challenges. World J Gastroenterol. 2016;22(18):4438–45.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Stahl JE, Kreke JE, Malek FAA, Schaefer AJ, Vacanti J. Consequences of cold-ischemia time on primary nonfunction and patient and graft survival in liver transplantation: a meta-analysis. PLoS One. 2008;3(6):e2468.

    Article  PubMed  PubMed Central  Google Scholar 

  13. [No title] [Internet]. [cited 2021 Apr 14]. https://optn.transplant.hrsa.gov/media/1200/optn_policies.pdf

  14. Yandza T, Aubert F, Fourcade L, Jan D, Lacaille F, Hubert P, et al. Update on criteria for cadaveric donor selection for liver transplantation. Gastroenterol Clin Biol. 2003;27(2):163–75.

    PubMed  Google Scholar 

  15. Kaseje N, McLin V, Toso C, Poncet A, Wildhaber BE. Donor hypernatremia before procurement and early outcomes following pediatric liver transplantation. Liver Transpl. 2015;21(8):1076–81.

    Article  PubMed  Google Scholar 

  16. Dahm F, Georgiev P, Clavien P-A. Small-for-size syndrome after partial liver transplantation: definition, mechanisms of disease and clinical implications. Am J Transplant. 2005;5(11):2605–10.

    Article  PubMed  Google Scholar 

  17. Mikolasevic I, Milic S, Filipec-Kanizaj T. Fatty liver allografts are associated with primary graft non-function and high mortality after transplantation. Liver Int. 2017;37(8):1113–5.

    Article  PubMed  Google Scholar 

  18. Perkins JD, Dick AA, Healey PJ, Montenovo MI, Biggins SW, Sibulesky L, et al. New evidence supporting increased use of split liver transplantation. Transplantation. 2020;104(2):299–307.

    Article  PubMed  Google Scholar 

  19. Reyes J, Gerber D, Mazariegos GV, Casavilla A, Sindhi R, Bueno J, et al. Split-liver transplantation: a comparison of ex vivo and in situ techniques. J Pediatr Surg. 2000;35(2):283–9. discussion 289–90

    Article  CAS  PubMed  Google Scholar 

  20. Fanna M, Baptiste A, Capito C, Ortego R, Pacifico R, Lesage F, et al. Preoperative risk factors for intra-operative bleeding in pediatric liver transplantation. Pediatr Transplant. 2016;20(8):1065–71.

    Article  PubMed  Google Scholar 

  21. Michels NA. Newer anatomy of the liver and its variant blood supply and collateral circulation [internet]. Am J Surg. 1966;112:337–47. https://doi.org/10.1016/0002-9610(66)90201-7.

    Article  CAS  PubMed  Google Scholar 

  22. Couinaud C. Le Foie: études anatomiques et chirurgicales. Préfaces des Prof. A. [André] Delmas et J. [Jean] Patel. Masson et Cie; 1957. 531 p.

    Google Scholar 

  23. Azoulay D, Marin-Hargreaves G, Castaing D, Bismuth H. Ex situ splitting of the liver: the versatile Paul Brousse technique. Arch Surg. 2001;136(8):956–61.

    Article  CAS  PubMed  Google Scholar 

  24. Azoulay D, Astarcioglu I, Bismuth H, Castaing D, Majno P, Adam R, et al. Split-liver transplantation. The Paul Brousse policy. Ann Surg. 1996;224(6):737–46. discussion 746–8

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  25. Ogawa K, Kasahara M, Sakamoto S, Ito T, Taira K, Oike F, et al. Living donor liver transplantation with reduced monosegments for neonates and small infants. Transplantation. 2007;83(10):1337–40.

    Article  PubMed  Google Scholar 

  26. Zakaria HM, Alobthani S, Elsarawy A, Saleh Y, Zidan A, Alabbad S, et al. Large for size in pediatrics liver transplant using left lateral segment grafts: a single center experience. Pediatr Transplant. 2021;25(6):e14044.

    Article  CAS  PubMed  Google Scholar 

  27. Fanna M, Masson G, Capito C, Girard M, Guerin F, Hermeziu B, et al. Management of Biliary Atresia in France 1986 to 2015: long-term results. J Pediatr Gastroenterol Nutr. 2019;69(4):416–24.

    Article  CAS  PubMed  Google Scholar 

  28. Strong R, Ong TH, Pillay P, Wall D, Balderson G, Lynch S. A new method of segmental orthotopic liver transplantation in children. Surgery. 1988;104(1):104–7.

    CAS  PubMed  Google Scholar 

  29. Emond JC, Heffron TG, Whitington PF, Broelsch CE. Reconstruction of the hepatic vein in reduced size hepatic transplantation. Surg Gynecol Obstet. 1993;176(1):11–7.

    CAS  PubMed  Google Scholar 

  30. Marwan IK, Fawzy AT, Egawa H, Inomata Y, Uemoto S, Asonuma K, et al. Innovative techniques for and results of portal vein reconstruction in living-related liver transplantation. Surgery. 1999;125(3):265–70.

    Article  CAS  PubMed  Google Scholar 

  31. de Magnée C, Bourdeaux C, De Dobbeleer F, Janssen M, Menten R, Clapuyt P, et al. Impact of pre-transplant liver hemodynamics and portal reconstruction techniques on post-transplant portal vein complications in pediatric liver transplantation: a retrospective analysis in 197 recipients. Ann Surg. 2011;254(1):55–61.

    Article  PubMed  Google Scholar 

  32. Lerut J, Gordon RD, Iwatsuki S, Starzl TE. Surgical complications in human orthotopic liver transplantation. Acta Chir Belg. 1987;87(3):193–204.

    CAS  PubMed  PubMed Central  Google Scholar 

  33. Moussaoui D, Toso C, Nowacka A, McLin VA, Bednarkiewicz M, Andres A, et al. Early complications after liver transplantation in children and adults: Are split grafts equal to each other and equal to whole livers? Pediatr Transplant [Internet]. 2017;21:4. https://doi.org/10.1111/petr.12908.

    Article  Google Scholar 

  34. Gavriilidis P, Roberts KJ, Azoulay D. Right lobe split liver graft versus whole liver transplantation: a systematic review by updated traditional and cumulative meta-analysis. Dig Liver Dis. 2018;50(12):1274–82.

    Article  PubMed  Google Scholar 

  35. Wan P, Li Q, Zhang J, Xia Q. Right lobe split liver transplantation versus whole liver transplantation in adult recipients: a systematic review and meta-analysis. Liver Transpl. 2015;21(7):928–43.

    Article  PubMed  Google Scholar 

  36. Maggi U, De Feo TM, Andorno E, Cillo U, De Carlis L, Colledan M, et al. Fifteen years and 382 extended right grafts from in situ split livers in a multicenter study: are these still extended criteria liver grafts? Liver Transpl. 2015;21(4):500–11.

    Article  PubMed  Google Scholar 

  37. Chul Yoon K, Song S, Jwa E-K, Lee S, Man Kim J, Kim O-K, et al. Survival outcomes in split compared with whole liver transplantation. Liver Transpl. 2018;24(10):1411–24.

    Article  PubMed  Google Scholar 

  38. Darius T, Rivera J, Fusaro F, Lai Q, de Magnée C, Bourdeaux C, et al. Risk factors and surgical management of anastomotic biliary complications after pediatric liver transplantation. Liver Transpl. 2014;20(8):893–903.

    Article  PubMed  Google Scholar 

  39. Doyle MBM, Maynard E, Lin Y, Vachharajani N, Shenoy S, Anderson C, et al. Outcomes with split liver transplantation are equivalent to those with whole organ transplantation. J Am Coll Surg. 2013;217(1):102–12. discussion 113–4

    Article  PubMed  Google Scholar 

  40. Salvalaggio PRO, Whitington PF, Alonso EM, Superina RA. Presence of multiple bile ducts in the liver graft increases the incidence of biliary complications in pediatric liver transplantation. Liver Transpl. 2005;11(2):161–6.

    Article  PubMed  Google Scholar 

  41. Darwish AA, Bourdeaux C, Kader HA, Janssen M, Sokal E, Lerut J, et al. Pediatric liver transplantation using left hepatic segments from living related donors: surgical experience in 100 recipients at Saint-Luc University Clinics. Pediatr Transplant. 2006;10(3):345–53.

    Article  PubMed  Google Scholar 

  42. Flynn E, Huang JY, Hardikar W, Herd L, Hodgson A, Monagle P. Antithrombotic management and thrombosis rates in children post-liver transplantation: a case series and literature review. Pediatr Transplant. 2019;23(4):e13420.

    Article  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Pediatric Surgery and Transplantation Department, Hôpital Necker Enfants Malades, Paris, France

    Lucas Rabaux, Christophe Chardot & Carmen Capito

  2. APHP, Université Paris Centre, Paris, France

    Lucas Rabaux, Christophe Chardot & Carmen Capito

Authors
  1. Lucas Rabaux
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  2. Christophe Chardot
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  3. Carmen Capito
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Corresponding author

Correspondence to Carmen Capito .

Editor information

Editors and Affiliations

  1. Recanati/Miller Transplantation Institute, Mount Sinai Hospital, NY, USA

    Ron Shapiro

  2. Division of Transplant Surgery, University of California, San Francisco, CA, USA

    Minnie M. Sarwal

  3. Department of Nephrology, Akron General Medical Center at Cleveland Clinic Foundation and Akron Children’s Hospital, OH, USA

    Rupesh Raina

  4. Kidney and Urology Institute, Medanta, The Medicity, Gurugram, Haryana, India

    Sidharth Kumar Sethi

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Rabaux, L., Chardot, C., Capito, C. (2023). Split Liver Transplantation. In: Shapiro, R., Sarwal, M.M., Raina, R., Sethi, S.K. (eds) Pediatric Solid Organ Transplantation. Springer, Singapore. https://doi.org/10.1007/978-981-19-6909-6_34

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  • DOI: https://doi.org/10.1007/978-981-19-6909-6_34

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  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-19-6908-9

  • Online ISBN: 978-981-19-6909-6

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