Skip to main content

Frailty and Mental Health in Older Patients with Gastrointestinal Cancer

  • Chapter
  • First Online:
Physical Therapy and Research in Patients with Cancer
  • 373 Accesses

Abstract

Frailty is highly prevalent in gastrointestinal cancer patients due to decreased food intake and gastrointestinal symptoms. Frailty is associated with postoperative complications, emergency room visits, and mortality, making preoperative screening important. Gastrointestinal cancer patients also have a high prevalence of postoperative psychiatric disorders due to postoperative complications, poor prognosis, and negative body image. Since psychiatric symptoms affect activities of daily living and quality of life, rehabilitation plays a significant role in treatment. Rehabilitation for gastrointestinal cancer patients is aimed at prevention of postoperative complications and improvement of physical function, and in recent years, pre-rehabilitation has been the focus of attention. The effects of exercise on mental health have been reported in several studies, and exercise is a low-cost and safe method for improving mental health. Finally, we discuss the association between social frailty and mental health, which is the topic of our research.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 249.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Ganjoho.jp [in Japanese]. National Cancer Center Japan [updated 2022 Mar 18; cited 2022 Mar 30]. Available from: https://ganjoho.jp/reg_stat/statistics/stat/summary.html.

  2. Fried LP, Tangen CM, Walston J, Newman AB, Hirsch C, Gottdiener J, et al. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci. 2001;56(3):M146–56.

    Article  CAS  Google Scholar 

  3. Dent E, Martin FC, Bergman H, Woo J, Romero-Ortuno R, Walston JD. Management of frailty: opportunities, challenges, and future directions. Lancet. 2019;394(10206):1376–86.

    Article  Google Scholar 

  4. Rockwood K, Song X, MacKnight C, Bergman H, Hogan DB, McDowell I, et al. A global clinical measure of fitness and frailty in elderly people. CMAJ. 2005;173(5):489–95.

    Article  Google Scholar 

  5. Rockwood K, Mitnitski A. Frailty in relation to the accumulation of deficits. J Gerontol A Biol Sci Med Sci. 2007;62(7):722–7.

    Article  Google Scholar 

  6. Handforth C, Clegg A, Young C, Simpkins S, Seymour MT, Selby PJ, et al. The prevalence and outcomes of frailty in older cancer patients: a systematic review. Ann Oncol. 2015;26(6):1091–101.

    Article  CAS  Google Scholar 

  7. Tan KY, Kawamura YJ, Tokomitsu A, Tang T. Assessment for frailty is useful for predicting morbidity in elderly patients undergoing colorectal cancer resection whose comorbidities are already optimized. Am J Surg. 2012;204(2):139–43.

    Article  Google Scholar 

  8. Chou WC, Lai CC, Hung CY, Hsueh SW, Yeh KY, Lu CH, et al. Clinical significance of frailty on treatment outcome in nongeriatric patients with head and neck cancer and esophageal cancer undergoing curative-intent concurrent chemoradiotherapy. Cancer Control. 2022;29:10732748211045276.

    Article  Google Scholar 

  9. Boakye D, Rillmann B, Walter V, Jansen L, Hoffmeister M, Brenner H. Impact of comorbidity and frailty on prognosis in colorectal cancer patients: a systematic review and meta-analysis. Cancer Treat Rev. 2018;64:30–9.

    Article  Google Scholar 

  10. Xia S, Sun M, Liu X. Major depression but not minor to intermediate depression correlates with unfavorable prognosis in surgical colorectal cancer patients underwent adjuvant chemotherapy. Psychol Health Med. 2020;25(3):309–18.

    Article  Google Scholar 

  11. Wikman A, Ljung R, Johar A, Hellstadius Y, Lagergren J, Lagergren P. Psychiatric morbidity and survival after surgery for esophageal cancer: a population-based cohort study. J Clin Oncol. 2015;33(5):448–54.

    Article  Google Scholar 

  12. Hu LY, Ku FC, Wang YP, Shen CC, Hu YW, Yeh CM, et al. Anxiety and depressive disorders among patients with esophageal cancer in Taiwan: a nationwide population-based study. Support Care Cancer. 2015;23(3):733–40.

    Article  Google Scholar 

  13. Bergquist H, Ruth M, Hammerlid E. Psychiatric morbidity among patients with cancer of the esophagus or the gastro-esophageal junction: a prospective, longitudinal evaluation. Dis Esophagus. 2007;20(6):523–9.

    Article  CAS  Google Scholar 

  14. Hellstadius Y, Lagergren J, Zylstra J, Gossage J, Davies A, Hultman CM, et al. A longitudinal assessment of psychological distress after oesophageal cancer surgery. Acta Oncol. 2017;56(5):746–52.

    Article  Google Scholar 

  15. Housman B, Flores R, Lee DS. Narrative review of anxiety and depression in patients with esophageal cancer: underappreciated and undertreated. J Thorac Dis. 2021;13(5):3160–70.

    Article  Google Scholar 

  16. Ayaz-Alkaya S. Overview of psychosocial problems in individuals with stoma: a review of literature. Int Wound J. 2019;16(1):243–9.

    Article  Google Scholar 

  17. Godby RC, Dai C, Al-Obaidi M, Giri S, Young-Smith C, Kenzik K, et al. Depression among older adults with gastrointestinal malignancies. J Geriatr Oncol. 2021;12(4):599–604.

    Article  CAS  Google Scholar 

  18. Wu Y, Zhang Y, Zou L. Effects of anxiety, depression, and fatigue on quality of life in early esophageal cancer patients following endoscopic submucosal dissection. Ann Palliat Med. 2020;9(6):3766–75.

    Article  Google Scholar 

  19. Ohkura Y, Ichikura K, Shindoh J, Ueno M, Udagawa H, Matsushima E. Relationship between psychological distress and health-related quality of life at each point of the treatment of esophageal cancer. Esophagus. 2020;17(3):312–22.

    Article  Google Scholar 

  20. Joseph B, Pandit V, Zangbar B, Kulvatunyou N, Hashmi A, Green DJ, et al. Superiority of frailty over age in predicting outcomes among geriatric trauma patients: a prospective analysis. JAMA Surg. 2014;149(8):766–72.

    Article  Google Scholar 

  21. Satake S, Shimada H, Yamada M, Kim H, Yoshida H, Gondo Y, et al. Prevalence of frailty among community-dwellers and outpatients in Japan as defined by the Japanese version of the Cardiovascular Health Study criteria. Geriatr Gerontol Int. 2017;17(12):2629–34.

    Article  Google Scholar 

  22. Satake S, Arai H. The revised Japanese version of the Cardiovascular Health Study criteria (revised J-CHS criteria). Geriatr Gerontol Int. 2020;20(10):992–3.

    Article  Google Scholar 

  23. Huisingh-Scheetz M, Walston J. How should older adults with cancer be evaluated for frailty? J Geriatr Oncol. 2017;8(1):8–15.

    Article  Google Scholar 

  24. Vellas B, Villars H, Abellan G, Soto ME, Rolland Y, Guigoz Y, et al. Overview of the MNA—its history and challenges. J Nutr Health Aging. 2006;10(6):456–63; discussion 63–5.

    CAS  Google Scholar 

  25. Mizutani T, Nakamura K, Fukuda H, Ogawa A, Hamaguchi T, Nagashima F, et al. Geriatric research policy: Japan Clinical Oncology Group (JCOG) policy. Jpn J Clin Oncol. 2019;49(10):901–10.

    Article  Google Scholar 

  26. Saliba D, Elliott M, Rubenstein LZ, Solomon DH, Young RT, Kamberg CJ, et al. The Vulnerable Elders Survey: a tool for identifying vulnerable older people in the community. J Am Geriatr Soc. 2001;49(12):1691–9.

    Article  CAS  Google Scholar 

  27. Okuyama T, Sugano K, Iida S, Ishida T, Kusumoto S, Akechi T. Screening performance for frailty among older patients with cancer: a cross-sectional observational study of two approaches. J Natl Compr Cancer Netw. 2015;13(12):1525–31.

    Article  CAS  Google Scholar 

  28. Zigmond AS, Snaith RP. The hospital anxiety and depression scale. Acta Psychiatr Scand. 1983;67(6):361–70.

    Article  CAS  Google Scholar 

  29. Kugaya A, Akechi T, Okuyama T, Okamura H, Uchitomi Y. Screening for psychological distress in Japanese cancer patients. Jpn J Clin Oncol. 1998;28(5):333–8.

    Article  CAS  Google Scholar 

  30. Singer S, Kuhnt S, Gotze H, Hauss J, Hinz A, Liebmann A, et al. Hospital anxiety and depression scale cutoff scores for cancer patients in acute care. Br J Cancer. 2009;100(6):908–12.

    Article  CAS  Google Scholar 

  31. Hann D, Winter K, Jacobsen P. Measurement of depressive symptoms in cancer patients: evaluation of the Center for Epidemiological Studies Depression Scale (CES-D). J Psychosom Res. 1999;46(5):437–43.

    Article  CAS  Google Scholar 

  32. Radloff LS. The CES-D scale : a self-report depression scale for research in the general population. Appl Psychol Meas. 1977;1(3):385–401.

    Article  Google Scholar 

  33. Shima S, Shikano T, Kitamura T. A new self-report depression scale (in Japanese). Seishin Igaku. 1985;27(6):717–23.

    Google Scholar 

  34. Yesavage JA, Sheikh JI. 9/Geriatric depression scale (GDS). Clin Gerontol. 1986;5(1–2):165–73.

    Article  Google Scholar 

  35. Lyness JM, Noel TK, Cox C, King DA, Conwell Y, Caine ED. Screening for depression in elderly primary care patients. A comparison of the Center for Epidemiologic Studies-depression scale and the geriatric depression scale. Arch Intern Med. 1997;157(4):449–54.

    Article  CAS  Google Scholar 

  36. Akizuki N, Yamawaki S, Akechi T, Nakano T, Uchitomi Y. Development of an Impact Thermometer for use in combination with the Distress Thermometer as a brief screening tool for adjustment disorders and/or major depression in cancer patients. J Pain Symptom Manag. 2005;29(1):91–9.

    Article  Google Scholar 

  37. Ashok A, Niyogi D, Ranganathan P, Tandon S, Bhaskar M, Karimundackal G, et al. The enhanced recovery after surgery (ERAS) protocol to promote recovery following esophageal cancer resection. Surg Today. 2020;50(4):323–34.

    Article  Google Scholar 

  38. Shida D, Tagawa K, Inada K, Nasu K, Seyama Y, Maeshiro T, et al. Enhanced recovery after surgery (ERAS) protocols for colorectal cancer in Japan. BMC Surg. 2015;15:90.

    Article  Google Scholar 

  39. Hanada M, Kanetaka K, Hidaka S, Taniguchi K, Oikawa M, Sato S, et al. Effect of early mobilization on postoperative pulmonary complications in patients undergoing video-assisted thoracoscopic surgery on the esophagus. Esophagus. 2018;15(2):69–74.

    Article  Google Scholar 

  40. Tetsuya T. Clinical manual for cancer rehabilitation. 2nd ed. Tokyo: Igaku-Shoin; 2021.

    Google Scholar 

  41. Hara T, Kubo A. The perioperative changes in physical function and physique of patients with gastrointestinal cancer. J Phys Ther Sci. 2015;27(3):693–5.

    Article  Google Scholar 

  42. Hara T, Kogure E, Iijima S, Fukawa Y, Kubo A, Kakuda W. Minimal clinically important difference in postoperative recovery among patients with gastrointestinal cancer. Support Care Cancer. 2022;30(3):2197–205.

    Article  Google Scholar 

  43. Van Blarigan EL, Meyerhardt JA. Role of physical activity and diet after colorectal cancer diagnosis. J Clin Oncol. 2015;33(16):1825–34.

    Article  Google Scholar 

  44. Meyerhardt JA, Giovannucci EL, Holmes MD, Chan AT, Chan JA, Colditz GA, et al. Physical activity and survival after colorectal cancer diagnosis. J Clin Oncol. 2006;24(22):3527–34.

    Article  Google Scholar 

  45. Lee MK, Kim NK, Jeon JY. Effect of the 6-week home-based exercise program on physical activity level and physical fitness in colorectal cancer survivors: a randomized controlled pilot study. PLoS One. 2018;13(4):e0196220.

    Article  Google Scholar 

  46. Kim JY, Lee MK, Lee DH, Kang DW, Min JH, Lee JW, et al. Effects of a 12-week home-based exercise program on quality of life, psychological health, and the level of physical activity in colorectal cancer survivors: a randomized controlled trial. Support Care Cancer. 2019;27(8):2933–40.

    Article  Google Scholar 

  47. Ichijo Y, Takeda Y, Oguma Y, Kitagawa Y, Takeuchi H, Doorenbos AZ. Physical activity among postoperative esophageal cancer patients. Cancer Nurs. 2019;42(6):501–8.

    Article  Google Scholar 

  48. Inoue J, Ono R, Makiura D, Kashiwa-Motoyama M, Miura Y, Usami M, et al. Prevention of postoperative pulmonary complications through intensive preoperative respiratory rehabilitation in patients with esophageal cancer. Dis Esophagus. 2013;26(1):68–74.

    Article  CAS  Google Scholar 

  49. Yamana I, Takeno S, Hashimoto T, Maki K, Shibata R, Shiwaku H, et al. Randomized controlled study to evaluate the efficacy of a preoperative respiratory rehabilitation program to prevent postoperative pulmonary complications after esophagectomy. Dig Surg. 2015;32(5):331–7.

    Article  Google Scholar 

  50. Lopez-Rodriguez-Arias F, Sanchez-Guillen L, Aranaz-Ostariz V, Triguero-Canovas D, Lario-Perez S, Barber-Valles X, et al. Effect of home-based prehabilitation in an enhanced recovery after surgery program for patients undergoing colorectal cancer surgery during the COVID-19 pandemic. Support Care Cancer. 2021;29(12):7785–91.

    Article  Google Scholar 

  51. Carli F, Bousquet-Dion G, Awasthi R, Elsherbini N, Liberman S, Boutros M, et al. Effect of multimodal prehabilitation vs postoperative rehabilitation on 30-day postoperative complications for frail patients undergoing resection of colorectal cancer: a randomized clinical trial. JAMA Surg. 2020;155(3):233–42.

    Article  Google Scholar 

  52. Knapen J, Vancampfort D, Morien Y, Marchal Y. Exercise therapy improves both mental and physical health in patients with major depression. Disabil Rehabil. 2015;37(16):1490–5.

    Article  Google Scholar 

  53. Barbour KA, Blumenthal JA. Exercise training and depression in older adults. Neurobiol Aging. 2005;26(Suppl 1):119–23.

    Article  Google Scholar 

  54. Carek PJ, Laibstain SE, Carek SM. Exercise for the treatment of depression and anxiety. Int J Psychiatry Med. 2011;41(1):15–28.

    Article  Google Scholar 

  55. Babyak M, Blumenthal JA, Herman S, Khatri P, Doraiswamy M, Moore K, et al. Exercise treatment for major depression: maintenance of therapeutic benefit at 10 months. Psychosom Med. 2000;62(5):633–8.

    Article  CAS  Google Scholar 

  56. Campbell KL, Winters-Stone KM, Wiskemann J, May AM, Schwartz AL, Courneya KS, et al. Exercise guidelines for cancer survivors: consensus statement from International Multidisciplinary Roundtable. Med Sci Sports Exerc. 2019;51(11):2375–90.

    Article  Google Scholar 

  57. Mishra SI, Scherer RW, Geigle PM, Berlanstein DR, Topaloglu O, Gotay CC, et al. Exercise interventions on health-related quality of life for cancer survivors. Cochrane Database Syst Rev. 2012;(8):CD007566.

    Google Scholar 

  58. Mishra SI, Scherer RW, Snyder C, Geigle PM, Berlanstein DR, Topaloglu O. Exercise interventions on health-related quality of life for people with cancer during active treatment. Cochrane Database Syst Rev. 2012;(8):CD008465.

    Google Scholar 

  59. Persoon S, Kersten MJ, van der Weiden K, Buffart LM, Nollet F, Brug J, et al. Effects of exercise in patients treated with stem cell transplantation for a hematologic malignancy: a systematic review and meta-analysis. Cancer Treat Rev. 2013;39(6):682–90.

    Article  Google Scholar 

  60. Zhou Y, Zhu J, Gu Z, Yin X. Efficacy of exercise interventions in patients with acute leukemia: a meta-analysis. PLoS One. 2016;11(7):e0159966.

    Article  Google Scholar 

  61. Lahart IM, Metsios GS, Nevill AM, Carmichael AR. Physical activity for women with breast cancer after adjuvant therapy. Cochrane Database Syst Rev. 2018;1:CD011292.

    Google Scholar 

  62. Brown JC, Huedo-Medina TB, Pescatello LS, Ryan SM, Pescatello SM, Moker E, et al. The efficacy of exercise in reducing depressive symptoms among cancer survivors: a meta-analysis. PLoS One. 2012;7(1):e30955.

    Article  CAS  Google Scholar 

  63. Craft LL, Vaniterson EH, Helenowski IB, Rademaker AW, Courneya KS. Exercise effects on depressive symptoms in cancer survivors: a systematic review and meta-analysis. Cancer Epidemiol Biomark Prev. 2012;21(1):3–19.

    Article  Google Scholar 

  64. Vallance JK, Boyle T, Courneya KS, Lynch BM. Accelerometer-assessed physical activity and sedentary time among colon cancer survivors: associations with psychological health outcomes. J Cancer Surviv. 2015;9(3):404–11.

    Article  Google Scholar 

  65. Loh KP, Kleckner IR, Lin PJ, Mohile SG, Canin BE, Flannery MA, et al. Effects of a home-based exercise program on anxiety and mood disturbances in older adults with cancer receiving chemotherapy. J Am Geriatr Soc. 2019;67(5):1005–11.

    Article  Google Scholar 

  66. Li J, Liu X. Incremental patient care program decreases anxiety, reduces depression and improves the quality of life in patients with colorectal cancer receiving adjuvant chemotherapy. Exp Ther Med. 2019;18(4):2789–98.

    CAS  Google Scholar 

  67. Zopf EM, Schulz H, Poeschko J, Aschenbroich K, Wilhelm T, Eypasch E, et al. Effects of supervised aerobic exercise on cardiorespiratory fitness and patient-reported health outcomes in colorectal cancer patients undergoing adjuvant chemotherapy-a pilot study. Support Care Cancer. 2022;30(3):1945–55.

    Article  Google Scholar 

  68. Lee MK, Oh J. Patient-reported outcomes of regular aerobic exercise in gastric cancer. Cancers (Basel). 2021;13(9):2080.

    Article  CAS  Google Scholar 

  69. Singh B, Hayes SC, Spence RR, Steele ML, Millet GY, Gergele L. Exercise and colorectal cancer: a systematic review and meta-analysis of exercise safety, feasibility and effectiveness. Int J Behav Nutr Phys Act. 2020;17(1):122.

    Article  Google Scholar 

  70. Mikkelsen K, Stojanovska L, Polenakovic M, Bosevski M, Apostolopoulos V. Exercise and mental health. Maturitas. 2017;106:48–56.

    Article  Google Scholar 

  71. Deslandes A, Moraes H, Ferreira C, Veiga H, Silveira H, Mouta R, et al. Exercise and mental health: many reasons to move. Neuropsychobiology. 2009;59(4):191–8.

    Article  Google Scholar 

  72. Lubans D, Richards J, Hillman C, Faulkner G, Beauchamp M, Nilsson M, et al. Physical activity for cognitive and mental health in youth: a systematic review of mechanisms. Pediatrics. 2016;138(3):e20161642.

    Article  Google Scholar 

  73. Xiao J. Physical exercise for human health, Advances in experimental medicine and biology, vol. 1228. Singapore: Springer; 2020.

    Book  Google Scholar 

  74. Kandola A, Ashdown-Franks G, Hendrikse J, Sabiston CM, Stubbs B. Physical activity and depression: towards understanding the antidepressant mechanisms of physical activity. Neurosci Biobehav Rev. 2019;107:525–39.

    Article  Google Scholar 

  75. Harber VJ, Sutton JR. Endorphins and exercise. Sports Med. 1984;1(2):154–71.

    Article  CAS  Google Scholar 

  76. Tendzegolskis Z, Viru A, Orlova E. Exercise-induced changes of endorphin contents in hypothalamus, hypophysis, adrenals and blood plasma. Int J Sports Med. 1991;12(5):495–7.

    Article  CAS  Google Scholar 

  77. Dishman RK, O’Connor PJ. Lessons in exercise neurobiology: the case of endorphins. Ment Health Phys Act. 2009;2(1):4–9.

    Article  Google Scholar 

  78. Zhang X, Gao F. Exercise improves vascular health: role of mitochondria. Free Radic Biol Med. 2021;177:347–59.

    Article  CAS  Google Scholar 

  79. Lundby C, Jacobs RA. Adaptations of skeletal muscle mitochondria to exercise training. Exp Physiol. 2016;101(1):17–22.

    Article  CAS  Google Scholar 

  80. Kempermann G. Regulation of adult hippocampal neurogenesis—implications for novel theories of major depression. Bipolar Disord. 2002;4(1):17–33.

    Article  Google Scholar 

  81. Hall MN. mTOR-what does it do? Transplant Proc. 2008;40(10 Suppl):S5–8.

    Article  CAS  Google Scholar 

  82. Lloyd BA, Hake HS, Ishiwata T, Farmer CE, Loetz EC, Fleshner M, et al. Exercise increases mTOR signaling in brain regions involved in cognition and emotional behavior. Behav Brain Res. 2017;323:56–67.

    Article  CAS  Google Scholar 

  83. Graber TE, McCamphill PK, Sossin WS. A recollection of mTOR signaling in learning and memory. Learn Mem. 2013;20(10):518–30.

    Article  CAS  Google Scholar 

  84. Cotman CW, Berchtold NC, Christie LA. Exercise builds brain health: key roles of growth factor cascades and inflammation. Trends Neurosci. 2007;30(9):464–72.

    Article  CAS  Google Scholar 

  85. Beurel E, Toups M, Nemeroff CB. The bidirectional relationship of depression and inflammation: double trouble. Neuron. 2020;107(2):234–56.

    Article  CAS  Google Scholar 

  86. Cervenka I, Agudelo LZ, Ruas JL. Kynurenines: tryptophan’s metabolites in exercise, inflammation, and mental health. Science. 2017;357(6349):eaaf9794.

    Article  Google Scholar 

  87. Herrstedt A, Bay ML, Simonsen C, Sundberg A, Egeland C, Thorsen-Streit S, et al. Exercise-mediated improvement of depression in patients with gastro-esophageal junction cancer is linked to kynurenine metabolism. Acta Oncol. 2019;58(5):579–87.

    Article  CAS  Google Scholar 

  88. Haller N, Lorenz S, Pfirrmann D, Koch C, Lieb K, Dettweiler U, et al. Individualized web-based exercise for the treatment of depression: randomized controlled trial. JMIR Ment Health. 2018;5(4):e10698.

    Article  Google Scholar 

  89. Legrand FD. Effects of exercise on physical self-concept, global self-esteem, and depression in women of low socioeconomic status with elevated depressive symptoms. J Sport Exerc Psychol. 2014;36(4):357–65.

    Article  Google Scholar 

  90. Zhang X, Pennell ML, Bernardo BM, Clark J, Krok-Schoen JL, Focht BC, et al. Body image, physical activity and psychological health in older female cancer survivors. J Geriatr Oncol. 2021;12(7):1059–67.

    Article  CAS  Google Scholar 

  91. Mendelson M, Borowik A, Michallet AS, Perrin C, Monneret D, Faure P, et al. Sleep quality, sleep duration and physical activity in obese adolescents: effects of exercise training. Pediatr Obes. 2016;11(1):26–32.

    Article  CAS  Google Scholar 

  92. Yang P-Y, Ho K-H, Chen H-C, Chien M-Y. Exercise training improves sleep quality in middle-aged and older adults with sleep problems: a systematic review. J Physiother. 2012;58(3):157–63.

    Article  Google Scholar 

  93. Bunt S, Steverink N, Olthof J, van der Schans CP, Hobbelen JSM. Social frailty in older adults: a scoping review. Eur J Ageing. 2017;14(3):323–34.

    Article  CAS  Google Scholar 

  94. Tsutsumimoto K, Doi T, Makizako H, Hotta R, Nakakubo S, Makino K, et al. Association of social frailty with both cognitive and physical deficits among older people. J Am Med Dir Assoc. 2017;18(7):603–7.

    Article  Google Scholar 

  95. Makizako H, Shimada H, Doi T, Tsutsumimoto K, Hotta R, Nakakubo S, et al. Social frailty leads to the development of physical frailty among physically non-frail adults: a four-year follow-up longitudinal cohort study. Int J Environ Res Public Health. 2018;15(3):490.

    Article  Google Scholar 

  96. Yamada M, Arai H. Social frailty predicts incident disability and mortality among community-dwelling japanese older adults. J Am Med Dir Assoc. 2018;19(12):1099–103.

    Article  Google Scholar 

  97. Ono R, Makiura D, Nakamura T, Okumura M, Fukuta A, Saito T, et al. Impact of preoperative social frailty on overall survival and cancer-specific survival among older patients with gastrointestinal cancer. J Am Med Dir Assoc. 2021;22(9):1825–30.e1.

    Article  Google Scholar 

  98. Makizako H, Shimada H, Tsutsumimoto K, Lee S, Doi T, Nakakubo S, et al. Social frailty in community-dwelling older adults as a risk factor for disability. J Am Med Dir Assoc. 2015;16(11):1003.e7–11.

    Article  Google Scholar 

  99. Flanagan J, Holmes S. Social perceptions of cancer and their impacts: implications for nursing practice arising from the literature. J Adv Nurs. 2000;32(3):740–9.

    Article  CAS  Google Scholar 

  100. Ernst M, Beutel ME, Brahler E. Cancer as a risk factor for distress and its interactions with sociodemographic variables in the context of the first wave of the COVID-19 pandemic in Germany. Sci Rep. 2022;12(1):2021.

    Article  CAS  Google Scholar 

  101. Tsuchiya M, Horio Y, Funazaki H, Aogi K, Miyauchi K, Arai Y, et al. Impact of gender and employment type on job loss among cancer survivors. Jpn J Clin Oncol. 2020;50(7):766–71.

    Article  Google Scholar 

  102. Okumura M, Inoue T, Melinda G, Saito T, Fukuta A, Makiura D, et al. Social frailty as a risk factor for new-onset depressive symptoms at one year post-surgery in older patients with gastrointestinal cancer. J Geriatr Oncol. 2020;11(5):904–7.

    Article  Google Scholar 

  103. Tsutsumimoto K, Doi T, Makizako H, Hotta R, Nakakubo S, Kim M, et al. Social frailty has a stronger impact on the onset of depressive symptoms than physical frailty or cognitive impairment: a 4-year follow-up longitudinal cohort study. J Am Med Dir Assoc. 2018;19(6):504–10.

    Article  Google Scholar 

  104. Hayashi T, Noguchi T, Kubo Y, Tomiyama N, Ochi A, Hayashi H. Social frailty and depressive symptoms during the COVID-19 pandemic among older adults in Japan: role of home exercise habits. Arch Gerontol Geriatr. 2022;98:104555.

    Article  CAS  Google Scholar 

  105. Noguchi T, Saito M, Aida J, Cable N, Tsuji T, Koyama S, et al. Association between social isolation and depression onset among older adults: a cross-national longitudinal study in England and Japan. BMJ Open. 2021;11(3):e045834.

    Article  Google Scholar 

  106. Liu B, Wu X, Shi L, Li H, Wu D, Lai X, et al. Correlations of social isolation and anxiety and depression symptoms among patients with breast cancer of Heilongjiang province in China: the mediating role of social support. Nurs Open. 2021;8(4):1981–9.

    Article  Google Scholar 

  107. Gonzalez-Saenz de Tejada M, Bilbao A, Bare M, Briones E, Sarasqueta C, Quintana JM, et al. Association between social support, functional status, and change in health-related quality of life and changes in anxiety and depression in colorectal cancer patients. Psychooncology. 2017;26(9):1263–9.

    Article  CAS  Google Scholar 

  108. Roh HW, Hong CH, Lee Y, Oh BH, Lee KS, Chang KJ, et al. Participation in physical, social, and religious activity and risk of depression in the elderly: a community-based three-year longitudinal study in Korea. PLoS One. 2015;10(7):e0132838.

    Article  Google Scholar 

  109. Kouvonen A, De Vogli R, Stafford M, Shipley MJ, Marmot MG, Cox T, et al. Social support and the likelihood of maintaining and improving levels of physical activity: the Whitehall II Study. Eur J Pub Health. 2012;22(4):514–8.

    Article  Google Scholar 

  110. Sarris J, O’Neil A, Coulson CE, Schweitzer I, Berk M. Lifestyle medicine for depression. BMC Psychiatry. 2014;14:107.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Maho Okumura .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2022 The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Okumura, M., Ono, R. (2022). Frailty and Mental Health in Older Patients with Gastrointestinal Cancer. In: Morishita, S., Inoue, J., Nakano, J. (eds) Physical Therapy and Research in Patients with Cancer. Springer, Singapore. https://doi.org/10.1007/978-981-19-6710-8_19

Download citation

  • DOI: https://doi.org/10.1007/978-981-19-6710-8_19

  • Published:

  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-19-6709-2

  • Online ISBN: 978-981-19-6710-8

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics