Abstract
Bone regeneration in the orofacial region is a significant health and economic burden. While surgical techniques for the treatment of bone deficiencies have been developed, several challenges still remain. This chapter describes the most common surgical treatments for vertical bone augmentation and critically analyses their drawbacks while elaborating on the emergence of additive manufacturing in this area. Pre-clinical research endeavours utilising 3D-printed scaffolds are then described and their perceived limitations are discussed. The final section of the chapter provides a description of current reconstruction techniques used in the case of severe bone atrophies and large-volume bone deficiencies prior to elaborating on the future of this field.
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References
Batstone MD (2018) Reconstruction of major defects of the jaws. Aust Dent J 63:S108–S113
Carrel J-P, Wiskott A, Moussa M, Rieder P, Scherrer S, Durual S (2016) A 3D printed TCP/HA structure as a new osteoconductive scaffold for vertical bone augmentation. Clin Oral Implants Res 27:55–62
Cipitria A, Reichert JC, Epari DR, Saifzadeh S, Berner A, Schell H, Mehta M, Schuetz MA, Duda GN, Hutmacher DW (2013) Polycaprolactone scaffold and reduced rhBMP-7 dose for the regeneration of critical-sized defects in sheep tibiae. Biomaterials 34(38):9960–9968
Goh BT, Teh LY, Tan DBP, Zhang Z, Teoh SH (2015) Novel 3D polycaprolactone scaffold for ridge preservation–a pilot randomised controlled clinical trial. Clin Oral Implants Res 26(3):271–277
Kende PP, Sarda AS, Desai H, Landge J, Nimma V, Varte V (2021) Complications of distraction osteogenesis: narrative review. Oral Surg 14(4):412–422
Khadembaschi D, Russell P, Beech N, Batstone MD (2021) Osseointegrated implant survival, success and prosthodontic outcomes in composite free flaps: a 10-year retrospective cohort study. Clin Oral Implants Res 32:1251–1261
Kumar SPT, Hashimi S, Saifzadeh S, Ivanovski S, Vaquette C (2018) Additively manufactured biphasic construct loaded with BMP-2 for vertical bone regeneration: a pilot study in rabbit. Mater Sci Eng C 92:554–564
Kumar VV, Rometsch E, Thor A, Wolvius E, Hurtado-Chong A (2020) Segmental mandibular reconstruction using tissue engineering strategies: a systematic review of individual patient data. Craniomaxillofac Trauma Reconstr 13:267–284
Le B, Rohrer MD, Prassad HS (2010) Screw “tent-pole” grafting technique for reconstruction of large vertical alveolar ridge defects using human mineralized allograft for implant site preparation. J Oral Maxillofac Surg 68(2):428–435
Moussa M, Carrel JP, Scherrer S, Cattani-Lorente M, Wiskott A, Durual S (2015) Medium-term function of a 3D printed TCP/HA structure as a new osteoconductive scaffold for vertical bone augmentation: a simulation by BMP-2 activation. Materials 8(5):2174–2190
Neovius E, Engstrand T (2010) Craniofacial reconstruction with bone and biomaterials: review over the last 11 years. J Plast Reconstr Aesthet Surg 63(10):1615–1623
Oryan A, Alidadi S, Moshiri A, Maffulli N (2014) Bone regenerative medicine: classic options, novel strategies, and future directions. J Orthop Surg Res 9(1):1
Rasperini G, Pilipchuk S, Flanagan C, Park C, Pagni G, Hollister S, Giannobile W (2015) 3D-printed bioresorbable scaffold for periodontal repair. J Dent Res 94(9 Suppl):153S–157S
Reichert JC, Cipitria A, Epari DR, Saifzadeh S, Krishnakanth P, Berner A, Woodruff MA, Schell H, Mehta M, Schuetz MA (2012) A tissue engineering solution for segmental defect regeneration in load-bearing long bones. Sci Transl Med 4(141):141ra93
Rocchietta I, Fontana F, Simion M (2008) Clinical outcomes of vertical bone augmentation to enable dental implant placement: a systematic review. J Clin Periodontol 35(s8):203–215
Scheller E, Krebsbach P, Kohn D (2009) Tissue engineering: state of the art in oral rehabilitation. J Oral Rehabil 36(5):368–389
Stevens MM (2008) Biomaterials for bone tissue engineering. Mater Today 11(5):18–25
Stoor P, Suomalainen A, Mesimaki K, Kontio R (2017) Rapid prototyped patient specific guiding implants in critical mandibular reconstruction. J Craniomaxillofac Surg 45:63–70
Tamimi F, Torres J, Gbureck U, Lopez-Cabarcos E, Bassett DC, Alkhraisat MH, Barralet JE (2009) Craniofacial vertical bone augmentation: a comparison between 3D printed monolithic monetite blocks and autologous onlay grafts in the rabbit. Biomaterials 30(31):6318–6326
Tamimi F, Torres J, Al-Abedalla K, Lopez-Cabarcos E, Alkhraisat MH, Bassett DC, Gbureck U, Barralet JE (2014) Osseointegration of dental implants in 3D-printed synthetic onlay grafts customized according to bone metabolic activity in recipient site. Biomaterials 35(21):5436–5445
Tevlin R, McArdle A, Atashroo D, Walmsley G, Senarath-Yapa K, Zielins E, Paik K, Longaker M, Wan D (2014) Biomaterials for craniofacial bone engineering. J Dent Res 93(12):1187–1195
Torres J, Tamimi F, Alkhraisat MH, Prados-Frutos JC, Rastikerdar E, Gbureck U, Barralet JE, López-Cabarcos E (2011) Vertical bone augmentation with 3D-synthetic monetite blocks in the rabbit calvaria. J Clin Periodontol 38(12):1147–1153
Urban I, Monje A, Wang H (2015) Vertical ridge augmentation and soft tissue reconstruction of the anterior atrophic maxillae: a case series. Int J Periodontics Restorative Dent 35:613–623
Van Genechten ML, Batstone MD (2016) The relative survival of composite free flaps in head and neck reconstruction. Int J Oral Maxillofac Surg 45:163–166
Vaquette C, Mitchell J, Fernandez-Medina T, Kumar S, Ivanovski S (2021) Resorbable additively manufactured scaffold imparts dimensional stability to extraskeletally regenerated bone. Biomaterials 269:120671
Von Arx T, Buser D (2006) Horizontal ridge augmentation using autogenous block grafts and the guided bone regeneration technique with collagen membranes: a clinical study with 42 patients. Clin Oral Implants Res 17(4):359–366
Ward B, Brown S, Krebsbach P (2010) Bioengineering strategies for regeneration of craniofacial bone: a review of emerging technologies. Oral Dis 16(8):709–716
Warnke PH, Wiltfang J, Springer I, Acil Y, Bolte H, Kosmahl M, Russo PA, Sherry E, Lützen U, Wolfart S, Terheyden H (2006) Man as living bioreactor: fate of an exogenously prepared customized tissue-engineered mandible. Biomaterials 27:3163–3167
Wolff KD, Mücke T, von Bomhard A, Ritschl LM, Schneider J, Humbs M, Fichter AM (2016) Free flap transplantation using an extracorporeal perfusion device: first three cases. J Craniomaxillofac Surg 44:148–154
Xiao Y (2014) Bone tissue engineering for dentistry and orthopaedics. Biomed Res Int 2014:241067
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Vaquette, C., Ivanovski, S., Batstone, M. (2023). Current Approaches in Vertical Bone Augmentation and Large Bone Deficiencies in the Orofacial Region. In: Chakravorty, N., Shukla, P.C. (eds) Regenerative Medicine. Springer, Singapore. https://doi.org/10.1007/978-981-19-6008-6_14
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DOI: https://doi.org/10.1007/978-981-19-6008-6_14
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