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Cytopenias Post Stem Cell Transplant

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Basics of Hematopoietic Stem Cell Transplant

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Abstract

One of the complications encountered after stem cell transplant (SCT) is the development of cytopenias, which can involve single lineage or multiple lineages. These cytopenias can be transient or long-lasting and increase the risks of morbidity and mortality. There can be multiple reasons for the development of cytopenias post-SCT. The common causes are drugs, infections particularly viral, development of new-onset autoimmunity, poor graft function and graft failure. Other causes include ABO incompatibility induced pure red cell aplasia, thrombotic thrombocytopenic purpura, hemophagocytosis, and post-transplant lymphoproliferative disorders. The patient should be evaluated for the above-mentioned causes. Treatment is directed to the cause and may vary from avoiding particular drugs or treatment of infection to CD34 stem cell booster and second SCT.

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  1. Department of Hemato-oncology and Bone Marrow Transplantation, Venkateshwar Hospital, New Delhi, Delhi, India

    Sanjeev Kumar Sharma

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Sharma, S.K. (2023). Cytopenias Post Stem Cell Transplant. In: Basics of Hematopoietic Stem Cell Transplant. Springer, Singapore. https://doi.org/10.1007/978-981-19-5802-1_53

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  • DOI: https://doi.org/10.1007/978-981-19-5802-1_53

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