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Basics of Stem Cell Transplant

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Basics of Hematopoietic Stem Cell Transplant

Abstract

Hematopoietic stem cell transplantation (SCT) is a procedure where the blood-forming stem cells of a donor are given to a recipient with the intention of replacing the defective or damaged hematopoietic system of the recipient. Conditioning chemotherapy is given before SCT. The conditioning, also called as a preparatory step prior to stem cell infusion, is generally considered the most important step in the SCT procedure, and it includes myeloablative, reduced intensity, and non-myeloablative conditioning or preparatory regimens. Its purposes are to help eradicate the patient’s disease prior to the transplant, to create marrow space for the donor cells, and to suppress the host’s immune system to prevent graft rejection. The two important arms of conditioning regimes are myeloablation and lymphoablation, and each conditioning regimen differing from the other with respect to these two parameters.

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Authors and Affiliations

  1. Department of Hemato-oncology and Bone Marrow Transplantation, Venkateshwar Hospital, New Delhi, Delhi, India

    Sanjeev Kumar Sharma

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  1. Sanjeev Kumar Sharma
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Sharma, S.K. (2023). Basics of Stem Cell Transplant. In: Basics of Hematopoietic Stem Cell Transplant. Springer, Singapore. https://doi.org/10.1007/978-981-19-5802-1_2

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  • DOI: https://doi.org/10.1007/978-981-19-5802-1_2

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  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-19-5801-4

  • Online ISBN: 978-981-19-5802-1

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