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Abstract

The greatest risk of death in the pediatric age is in the first 28 days of neonatal period life. Neonatal Mortality Rate (NMR) is a huge burden globally. Ninety eight percent of neonatal deaths occur in the developing countries. In 2019, 2.4 million children died in the 1st month of life (6,700/day), with 1/3rd within 1st 24 h and 3/4th within the 1st week of life. (UNICEF 2020). India contributes to nearly 16% of maternal deaths and 27% newborn deaths. The actual figures are higher as many deaths go unreported, with a wide regional variation. Common causes of neonatal mortality are infections, birth asphyxia and injuries, premature births, and congenital defects. Efforts are being taken to bring NMR down comparable to developed countries, but more needs to be done. This requires simultaneous stringent approaches at all levels starting from public awareness and education, health of the girl child, preconception, antenatal up to postnatal care and continued into the neonatal care of the newborn baby, immunization, prevention, early detection and management of diseases and illness. Anesthesia related morbidity and mortality is also high in neonates born premature, with low birth weight, hyperbilirubinemia, hypothermia, and congenital defects, added on to the risks due to the surgical condition. Preventive initiatives have a great impact on reducing perioperative morbidity and mortality in the surgical neonate.

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References

  1. WHO. Improving birth outcomes: meeting the challenge in the developing world. Washington, DC: The National Academies Press; 2003. https://doi.org/10.17226/10841).

    Book  Google Scholar 

  2. Joint statement: international who recommendations on interventions to improve preterm birth outcomes. A Commitment to Action from Professional Health Organizations; 2017.

    Google Scholar 

  3. The Partnership for Maternal, Newborn and Child Health in Support of Every Woman Every Child (PMNCH). Strategic Plan 2016-2020. Geneva, Switzerland: PMNCH. http://www.who.int/pmnch/knowledge/publications/pmnch_strategic_plan_2016_2020.pdf.

  4. WHO, UNICEF. Every newborn: an action plan to end preventable deaths: executive summary. Geneva, Switzerland: World Health Organization; 2014. https://www.everynewborn.org/Documents/Every_Newborn_Action_Plan.

    Google Scholar 

  5. Joint statement: health professional groups key to reducing MDGs 4 & 5. PMNCH; 2007. http://www.who.int/pmnch/events/2006/HCPjointstaterev0102207.pdf. 5.

  6. Saving mothers and babies: the role of strong professional associations. FIGO; 2012. http://www.figo.org/sites/default/files/uploads/projectpublications/LOGIC/Final%20Version%20of%20LOGIC%20publication%20for%20print.pdf.

  7. WHO recommendations on interventions to improve preterm birth outcomes. Geneva; 2015. http://www.who.int/reproductivehealth/publications/maternal_perinatal_health/preterm-birth-guideline/en/.

  8. Bang AT, Bang RA, Baitule S, Deshmukh M, Reddy MH. Burden of morbidities and the unmet need for health care in rural neonates: a prospective observational study in Gadchiroli, India. Indian Pediatrics. 2001;38:952–67.

    PubMed  CAS  Google Scholar 

  9. A neglected tragedy-the global burden of stillbirths. Report of the UN inter-agency group for child mortality estimation; Oct 2020. UNICEF.

    Google Scholar 

  10. Hug L, You D, Blencowe H, Mishra A, et al. Global, regional, and national estimates and trends in stillbirths from 2000 to 2019: a systematic assessment. Lancet. 2021(398):772–85.

    Google Scholar 

  11. Stoll BJ. Neonatal infections: a global perspective. In: Remington J, Klein J, editors. Infectious diseases of the fetus and newborn infant. Philadelphia: W.B. Saunders; 2000.

    Google Scholar 

  12. United Nations Children’s Fund (UNICEF). Tuberculosis now a global threat; 2000. https://www.unicef.org/newsline/00pr24.htm.

  13. WHO. Neonatal tetanus: progress towards global elimination, 1990–1997; 1999a. http://www.who.int/vaccines-diseases/diseases/Neonatal Tetanus.shtml.

  14. Lumbiganon P, Piaggio G, Villar J, Pinol A, et al. WHO Antenatal Care Trial Research Group. The epidemiology of syphilis in pregnancy. Int J STD AIDS. 2002;13(7):486–94.

    Article  PubMed  CAS  Google Scholar 

  15. Frank D, Duke T. Congenital syphilis at Goroka Base Hospital: incidence, clinical features and risk factors for mortality. Papua New Guinea Med J. 2000;43(1–2):121–6.

    CAS  Google Scholar 

  16. Jacobs RF. Neonatal herpes simplex virus infections. Semin Perinatol. 1998;22(1):64–71.

    Article  PubMed  CAS  Google Scholar 

  17. Paul VK, Singh M, Sundaram KR, Deorari AK. Correlates of mortality among hospital-born neonates with birth asphyxia. Natl Med J India. 1997;10(2):54–7.

    PubMed  CAS  Google Scholar 

  18. Chandra S, Ramji S, Thirupuram S. Perinatal asphyxia: multivariate analysis of risk factors in hospital births. Indian Pediatr. 1997;34(3):206–12.

    PubMed  CAS  Google Scholar 

  19. Saugstad OD. Resuscitation with room-air or oxygen supplementation. Clin Perinatol. 1998;25(3):741–56, xi.

    Article  PubMed  CAS  Google Scholar 

  20. Saugstad OD, Rootwelt T, Aalen O. Resuscitation of asphyxiated newborn infants with room air or oxygen: an international controlled trial: the Resair 2 study. Pediatrics. 1998;102(1):E1.

    Article  PubMed  CAS  Google Scholar 

  21. Deorari AK, Paul VK, Singh M, Vidyasagar D. The national movement of neonatal resuscitation in India. J Trop Pediatr. 2000;46(5):315–7.

    Article  PubMed  CAS  Google Scholar 

  22. Ellis M, Manandhar DS, Manandhar N, Wyatt J, et al. Stillbirths and neonatal encephalopathy in Kathmandu, Nepal: an estimate of the contribution of birth asphyxia to perinatal mortality in a low-income urban population. Paediatr Perinatal Epidemiol. 2000;14(1):39–52.

    Article  CAS  Google Scholar 

  23. Ellis M, Manandhar N, Shrestha PS, Shrestha L, et al. Outcome at 1 year of Neonatal encephalopathy in Kathmandu, Nepal. Dev Med Child Neurol. 1999;41(10):689–95.

    Article  PubMed  CAS  Google Scholar 

  24. Blencowe H, Lee A, Cousens S, et al. Preterm birth-associated neurodevelopmental impairment estimates at regional and global levels for 2010. Pediatr Res. 2013;74:17–34. https://doi.org/10.1038/pr.2013.204.

    Article  PubMed  PubMed Central  Google Scholar 

  25. Blencowe H, Krasevec J, de Onis M, Black RB, et al. National, regional, and worldwide estimates of low birthweight in 2015, with trends from 2000: a systematic analysis. Articles. 2019;7(7):E849–60.

    Google Scholar 

  26. Lams JD, Romero R, Culhane J, Goldenberg RL. Primary, secondary, and tertiary interventions to reduce the morbidity and mortality of preterm birth. Preterm Birth. 2008;371(9607):164–75. https://doi.org/10.1016/S0140-6736(08)60108-7.

    Article  Google Scholar 

  27. Ellis M, Manandhar N, Shakya U, Manandhar DS, et al. Postnatal hypothermia and cold stress among newborn infants in Nepal monitored by continuous ambulatory recording. Arch Dis Childhood Fetal Neonatal Ed. 1996;75(1):F42–5.

    Article  CAS  Google Scholar 

  28. Manzar S. Role of hypothermia in asphyxia. Pediatrics. 1999;104(5 Pt 1):1169.

    Article  PubMed  CAS  Google Scholar 

  29. Choudhary SP, Bajaj RK, Gupta RK. Knowledge, attitude and practices about Neonatal hypothermia among medical and paramedical staff. Indian J Pediatr. 2000;67(7):491–6.

    Article  PubMed  CAS  Google Scholar 

  30. van den Broek NR, Letsky EA. Etiology of anemia in pregnancy in south Malawi. Am J Clin Nutr. 2000;72(1 suppl):247S–56S.

    Article  PubMed  Google Scholar 

  31. Carroli G, Rooney C, Villar J. WHO Programme to map the best reproductive health practices: how effective is antenatal care in preventing maternal mortality and serious morbidity? Paediatr Perinatal Epidemiol. 2001a;15(suppl 1):1–42.

    Article  Google Scholar 

  32. Biancuzzo M. Breastfeeding the newborn clinical strategies for nurses. St. Louis, MO: Mosby; 1999.

    Book  Google Scholar 

  33. Katz J, West KP Jr, Khatry SK, et al. Maternal low-dose vitamin A or β-carotene supplementation has no effect on fetal loss and early infant mortality: a randomized cluster trial in Nepal. Am Soc Clin Nutr. 2000;71(16):1570–6.

    Article  CAS  Google Scholar 

  34. Bang AT, Bang RA, Baitule SB, et al. Effect of home-based Neonatal care and management of sepsis on neonatal mortality: field trial in rural India. Lancet. 1999;354(9194):1955–61.

    Article  PubMed  CAS  Google Scholar 

  35. World Health Organization (WHO). Essential newborn care. Geneva: WHO. 1996. http://www.who.int/reproductive-health/publications/MSM_96_13/MSM_96.

  36. United Nations Children’s Fund (UNICEF). The progress of nations. New York: UNICEF; 1999. www.unicef.org/pubsgen/pon99/index.html.

    Google Scholar 

  37. Committee on Fetus and Newborn. Levels of neonatal care. Pediatrics. 2004;114(5):1341–7. https://doi.org/10.1542/peds.2004-1697.

    Article  Google Scholar 

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Saha, U. (2023). Neonatal Mortality and Morbidity: The Burden. In: Saha, U. (eds) Clinical Anesthesia for the Newborn and the Neonate. Springer, Singapore. https://doi.org/10.1007/978-981-19-5458-0_1

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  • DOI: https://doi.org/10.1007/978-981-19-5458-0_1

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