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Toxic Optic Neuropathy

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Neuro-Ophthalmology

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Abstract

A 32-year-old male ambulance driver complained burry vision in both eyes for 2 weeks. He denied headache and eye pain. He was diagnosed with tuberculous pleuritic and treatment medications including ethambutol were given for 3 months. The dosage of ethambutol was 750 mg bid, together with regular dosage of rifampin and isoniazid. He also complained numbness of limbs when decreased vision happened. His physician referred him for neuro-ophthalmological evaluation.

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References

Case 1: Ethambutol Toxic Neuropathy

  1. Grzybowski A, Zülsdorff M, Wilhelm H, Tonagel F. Toxic optic neuropathies: an updated review. Acta Ophthalmol. 2015;93(5):402–10.

    Article  PubMed  Google Scholar 

  2. Lee EJ, Kim SJ, Choung HK, Kim JH, Yu YS. Incidence and clinical features of ethambutol-induced optic neuropathy in Korea. J Neuroophthalmol. 2008;28(4):269–77.

    Article  PubMed  Google Scholar 

  3. Russo PA, Chaglasian MA. Toxic optic neuropathy associated with ethambutol: implications for current therapy. J Am Optom Assoc. 1994;65(5):332–8.

    PubMed  CAS  Google Scholar 

Case 2: Ethambutol Toxic Neuropathy in OPA1 Mutation

  1. Wang MY, Sadun AA. Drug-related mitochondrial optic neuropathies. J Neuroophthalmol. 2013;33(2):172–8.

    Article  PubMed  CAS  Google Scholar 

  2. Guillet V, Chevrollier A, Cassereau J, et al. Ethambutol-induced optic neuropathy linked to OPA1 mutation and mitochondrial toxicity. Mitochondrion. 2010;10(2):115–24.

    Article  PubMed  CAS  Google Scholar 

  3. Gan D, Li M, Wu J, Sun X, Tian G. Analysis of genetic mutations in a cohort of hereditary optic neuropathy in Shanghai. J Ophthalmol. 2017;2017:6186052.

    Article  PubMed  PubMed Central  Google Scholar 

  4. Hwang JM, Kim J, Park SS. Leber’s hereditary optic neuropathy mutations in ethambutol-induced optic neuropathy. J Neurol. 2003;250(1):87–9.

    Article  PubMed  Google Scholar 

  5. Han J, Byun MK, Lee J, et al. Longitudinal analysis of retinal nerve fiber layer and ganglion cell-inner plexiform layer thickness in ethambutol-induced optic neuropathy. Graefes Arch Clin Exp Ophthalmol. 2015;253(12):2293–9.

    Article  PubMed  CAS  Google Scholar 

Case 3: Toxic Optic Neuropathy (Methanol)

  1. Gee P, Martin E. Toxic cocktail: methanol poisoning in a tourist to Indonesia. Emerg Med Australas. 2012;24(4):451–3.

    Article  PubMed  Google Scholar 

  2. Wan H, Sha Y, Zhang F, Hong R, Tian G, Fan H. Diffusion-weighted imaging using readout-segmented echo-planar imaging, parallel imaging, and two-dimensional navigator-based reacquisition in detecting acute optic neuritis. J Magn Reson Imaging. 2016;43(3):655–60.

    Article  PubMed  Google Scholar 

  3. Lu P, Sha Y, Wan H, Wang F, Tian G. Role of coronal high-resolution diffusion-weighted imaging in acute optic neuritis: a comparison with axial orientation. Neuroradiology. 2017;59(8):737–45.

    Article  PubMed  Google Scholar 

  4. Tanrivermis Sayit A, Aslan K, Elmali M, Gungor I. Methanol-induced toxic optic neuropathy with diffusion weighted MRI findings. Cutan Ocul Toxicol. 2016;35(4):337–40.

    Article  PubMed  CAS  Google Scholar 

Case 4: Toxic Optic Neuropathy (Penicillamine)

  1. Klingele TG, Burde RM. Optic neuropathy associated with penicillamine therapy in a patient with rheumatoid arthritis. J Clin Neuroophthalmol. 1984;4(2):75–8.

    PubMed  CAS  Google Scholar 

  2. Lee AH, Lawton NF. Penicillamine treatment of Wilson’s disease and optic neuropathy. J Neurol Neurosurg Psychiatry. 1991;54(8):746.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

Case 5: Toxic Optic Neuropathy (Thiamine-Deficient)

  1. Yeh WY, Lian LM, Chang A, Cheng CK. Thiamine-deficient optic neuropathy associated with Wernicke's encephalopathy in patients with chronic diarrhea. J Formos Med Assoc. 2013;112(3):165–70.

    Article  PubMed  Google Scholar 

  2. Lawton AW, Frisard NE. Visual loss, retinal hemorrhages, and optic disc edema resulting from thiamine deficiency following bariatric surgery complicated by prolonged vomiting. Ochsner J. 2017;17(1):112–4.

    PubMed  PubMed Central  Google Scholar 

  3. Singh S, Kumar A. Wernicke encephalopathy after obesity surgery: a systematic review. Neurology. 2007;68(11):807–11.

    Article  PubMed  Google Scholar 

  4. Van Stavern G, Kumar G, Thuruthumaly C. Visual disturbance after bariatric surgery. JAMA Ophthalmol. 2015;133(3):345–6.

    Article  PubMed  Google Scholar 

  5. Li JM, Rucker JC. Irreversible optic neuropathy in Wernicke encephalopathy and Leber hereditary optic neuropathy. J Neuroophthalmol. 2010;30(1):49–53.

    Article  PubMed  Google Scholar 

  6. Sia PI, Sia DI, Crompton JL, Casson RJ. Nerve fiber layer infarcts in thiamine deficiency. J Neuroophthalmol. 2015;35(3):274–6.

    Article  PubMed  Google Scholar 

  7. Beh SC, Frohman TC, Frohman EM. Isolated mammillary body involvement on MRI in Wernicke’s encephalopathy. J Neurol Sci. 2013;334(1):172–5.

    Article  PubMed  Google Scholar 

Case 6: Toxic Optic Neuropathy (Anthelmintic)

  1. Patel P, Ross A, Henretig FM, Liu G, Harding B, Panzer J. Clinical reasoning: a 12-year-old girl with headache and change in mental status. Neurology. 2018;90(11):524–9.

    Article  PubMed  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. Eye and ENT Hospital, Fudan University, Shanghai, China

    Guohong Tian & Xinghuai Sun

  2. Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China

    Guixian Zhao

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  1. Guohong Tian
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  2. Xinghuai Sun
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  3. Guixian Zhao
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Correspondence to Guohong Tian .

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Editors and Affiliations

  1. Eye & ENT Hospital, Fudan University, Shanghai, Shanghai, China

    Guohong Tian

  2. Eye & ENT Hospital, Fudan University, Shanghai, Shanghai, China

    Xinghuai Sun

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Tian, G., Sun, X., Zhao, G. (2022). Toxic Optic Neuropathy. In: Tian, G., Sun, X. (eds) Neuro-Ophthalmology. Springer, Singapore. https://doi.org/10.1007/978-981-19-4668-4_10

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  • DOI: https://doi.org/10.1007/978-981-19-4668-4_10

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  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-19-4667-7

  • Online ISBN: 978-981-19-4668-4

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