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Interaction of Ionizing Radiation with Matter

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Radiation Safety Guide for Nuclear Medicine Professionals

Abstract

The kinetic energy of radiation released during radioactive decay is measured in electron volts (eV). An electron volt is the kinetic energy gained by an electron when accelerated by a 1 volt potential difference. A volt of electrons is a tiny unit. The energy of various radiations released during radioactive decay (including X-rays) will be substantially greater; hence they are measured in kilo (103) electron volts (keV) or million (106) electron volts (MeV). In contrast, visible light has an energy of 1 to 4 eV.

The radiation released by a radioisotope is invisible to the naked eye and cannot be felt by the human body. They interact with the atoms when they strike matter to cause excitations and ionizations. Excitation is raising an atom’s orbital electron to a higher energy state, while ionization is the process of removing one or more electrons from an atom, resulting in the formation of an ion pair, a positive and a negative ion. Both of these processes result in energy being transferred from radiation to matter. Ionizing radiations are so named because they have the capacity to ionize materials.

The biological, chemical and physical impacts of radiation are ultimately due to ionization. This feature of radiation is utilized to detect and measure ionizing radiations. The interaction of ionizing radiation with matter is covered in Sect. 1 of this chapter.

Electromagnetic and particulate ionizing radiations are the two types of ionizing radiation where charged and uncharged particles may be found in particle radiation. In addition, Sect. 2 of this chapter briefly discusses the different methods for producing radionuclides utilized in nuclear medicine.

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References

  1. Vertes A, Nagy S, Klencsár Z, Lovas RG, Rösch F. Handbook of Nuclear Chemistry, vol. 4. Heidelberg, Germany: Springer; 2011; see the contribution by Mirzadeh, S., Mausner, L.F., Garland, M.A. on Reactor produced medical radionuclides, page 1857; by Qaim, S.M. on Cyclotron production of medical radionuclides, page 1903; and by Rösch, F., Knapp, F.F. on Radionuclide generators, page 1935

    Book  Google Scholar 

  2. Manual for Reactor Produced Radionuclides, IAEA-TECDOC-1340, IAEA, Vienna, Austria, 2003.

    Google Scholar 

  3. Wilbur DS. Chemical and radiochemical considerations in radiolabeling with α-emitting radionuclides. Curr Radiopharm. 2011;4:214–47.

    Article  CAS  PubMed  Google Scholar 

  4. Lahiri S, Maiti M. Recent developments in nuclear data measurements and chemical separation methods in accelerator production of astatine and technetium radionuclides. Radiochim Acta. 2012;100:85–94.

    Article  CAS  Google Scholar 

  5. Crawford JR, Yang H, Kunz P, Wilbur DS, Schaffer P, Ruth TJ. Development of a preclinical 211Rn/211At generator system for targeted alpha therapy research with 211At. Nucl Med Biol. 2017;48:31–5.

    Article  CAS  PubMed  Google Scholar 

  6. Qaim, S.M., Tárkányi, F., Capote, R. Nuclear Data for the Production of Therapeutic Radionuclides. IAEA Technical Report Series No. 473, IAEA, Vienna, Austria, 2011.

    Google Scholar 

  7. Zalutsky MR, Zhao XG, Alston KL, Bigner D. High-level production of alpha-particle emitting 211At and preparation of 211At-labeled antibodies for clinical use. J Med Med. 2001;42:1508–15.

    CAS  Google Scholar 

  8. Lebeda O, Jiran R, Rális J, Stursa J. A new internal target system for production of 211At on the cyclotron U-120M. Appl Radiat Isot. 2005;63:49–53.

    Article  CAS  PubMed  Google Scholar 

  9. O’Hara MJ, Krzysko AJ, Niver CM, Morrison SS, Owsley SL, Hamlin DK, Dorman EF, Wilbur DS. An automated flow system incorporating in-line acid dissolution of bismuth metal from a cyclotron irradiated target assembly for use in the isolation of astatine-211. Appl Radiat Isot. 2017;122:202–10.

    Article  PubMed  Google Scholar 

  10. Sathekge M, Knoesen O, Meckel M, Modiselle M, Vorster M, Marx S. 213Bi-PSMA-617 targeted alpha-radionuclide therapy in metastatic castration-resistant prostate cancer. Eur J Nucl Med Mol Imaging. 2017;44:1099–100.

    Article  PubMed  PubMed Central  Google Scholar 

  11. Apostolidis C, Molinet R, Rasmussen G, Morgenstern A. Production of 225Ac from 229Th for targeted alpha therapy. Anal Chem. 2005;77:6288–91.

    Article  CAS  PubMed  Google Scholar 

  12. Rösch F, Riss PJ. The renaissance of the 68Ge/68Ga radionuclide generator initiates new developments in Ga-68 radiopharmaceutical chemistry. Curr Top Med Chem. 2010;10:1633–68.

    Article  Google Scholar 

  13. Rösch F, Baum RP. Generator-based PET radiopharmaceuticals for molecular imaging of tumors: on the way to THERANOSTICS. Dalton Trans. 2011;40:6104–11.

    Article  PubMed  Google Scholar 

  14. Van der Meulen NP, van der Walt TN, Steyn GF, Raubenheimer HG. The production of 82Sr using larger format RbCl targets. Appl Radiat Isot. 2013;72:96–9.

    Article  PubMed  Google Scholar 

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Tandon, P., Prakash, D., Kheruka, S.C., Bhat, N.N. (2022). Interaction of Ionizing Radiation with Matter. In: Radiation Safety Guide for Nuclear Medicine Professionals. Springer, Singapore. https://doi.org/10.1007/978-981-19-4518-2_3

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  • DOI: https://doi.org/10.1007/978-981-19-4518-2_3

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