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Gut Microbiome in Health and Gastrointestinal Cancer

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Microbiome in Gastrointestinal Cancer

Abstract

Human gastrointestinal tract harbours trillions of microbes including bacteria, fungi, and viruses to form the gut microbiome. The recent advance in both bioinformatic analyses and functional investigations has greatly improved understandings of the complex host–microbe interactions. The gut microbiome has shown their impacts across a variety of physiological functions. Whereas dysbiosis or alterations in the gut microbiome is correlated with pathogenesis and progression of numerous diseases including cancer. In this chapter, the contribution of a healthy gut microbiome to digestion and immunity of the host is discussed. The association of a dysbiotic microbiome with the development of common gastrointestinal cancers (colorectal cancer, gastric cancer, and hepatopancreatic cancer) is also explored. The article is summarised with highlight of the current limitations and opportunities to advance this line of research.

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  1. Institute of Digestive Disease and The Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong, China

    Harry Cheuk-Hay Lau

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  1. Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Hong Kong, China

    Jun Yu

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Lau, H.CH. (2023). Gut Microbiome in Health and Gastrointestinal Cancer. In: Yu, J. (eds) Microbiome in Gastrointestinal Cancer. Springer, Singapore. https://doi.org/10.1007/978-981-19-4492-5_2

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