Skip to main content

Crohn’s Disease-Associated Lower Gastrointestinal Cancer

  • Chapter
  • First Online:
Atlas of Inflammatory Bowel Disease-Associated Intestinal Cancer
  • 210 Accesses

Abstract

Crohn’s disease (CD) carries the same risk of carcinogenesis as ulcerative colitis (UC) [1], and the number of CD-associated cancer cases is increasing in Japan concurrent with an increase in the number of long-term cases [2]. However, the number of CD cases complicated with cancer is much lower than that of UC cases complicated with cancer. Additionally, the morphological analysis of CD-associated gastrointestinal cancers is not as advanced because the entire gastrointestinal tract is at risk; endoscopy is limited by stenosis, fistulae, and anal lesions; and frequency of CD-associated cancers is high in the rectal and anal regions, where gastroenterologists are least familiar. In this chapter, we present our experience with CD-associated lower gastrointestinal cancers and describe current issues, focusing on diagnosis [3]. The description of the presented cases is included in Sect. 3 of the text, and the corresponding cases are indicated by (). The description of cancer lesions is based on the 9th edition of the Japanese Classification of Colorectal, Appendiceal, and Anal Carcinoma [4].

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

eBook
USD 16.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 89.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Similar content being viewed by others

References

  1. Zisman TL, Rubin DT. Colorectal cancer and dysplasia in inflammatory bowel disease. World J Gastroenterol. 2008;14:2662–9.

    Article  Google Scholar 

  2. Higashi D, Katsuno H, Kimura H, et al. Current state of and problems related to cancer of the intestinal tract associated with Crohn’s disease in Japan. Anticancer Res. 2016;36(7):3761–6.

    PubMed  Google Scholar 

  3. Futami K, Higashi D, Hirano Y, et al. Surgery for cancer complicated by Crohn’s disease. Surgery. 2017;71:1029–38. (in Japanese)

    Google Scholar 

  4. Sugihara K, editor. Japanese classification of colorectal, appendiceal, anal carcinoma. 9th ed. Tokyo: Kanehara Shuppan; 2018.

    Google Scholar 

  5. Canavan C, Abrams KR, Mayberry J. Meta-analysis: colorectal and small bowel cancer risk in patients with Crohn’s disease. Aliment Pharmacol Ther. 2006;23:1097–104.

    Article  CAS  Google Scholar 

  6. Sugita A, Koganei K, Tatsumi K, et al. Rectal and anal canal carcinoma associated with Crohn’s disease. J Jpn Soc Gastroenterol. 2013;110(3):396–402. (in Japanese)

    Google Scholar 

  7. Greenstein AJ, Sachar D, Pucillo A, et al. Cancer in Crohn’s disease after diversionary surgery. A report of seven carcinomas occurring in the excluded bowel. Am J Surg. 1978;135:86–90.

    Article  CAS  Google Scholar 

  8. Piton G, Cosnes J, Monnet E, et al. Risk factors associated with small bowel adenocarcinoma in Crohn’s disease: a case-control study. Am J Gastroenterol. 2008;103(7):1730–6.

    Article  Google Scholar 

  9. Ikeuchi H, Uchino M, Matsuoka H, et al. Cancer of Crohn’s disease and future measures. Intestine. 2010;14:505–10. (in Japanese)

    Google Scholar 

  10. Futami K, Higashi J, Egawa Y, et al. Diagnosis, treatment, and prognosis of patients with carcinoma of Crohn’s disease. Gastroenterol Surg. 2013;36(1):97–105. (in Japanese)

    Google Scholar 

  11. Hata J, Imamura Y, Manabe N, et al. Extracorporeal ultrasound of the gastrointestinal tract. Stomach Intestine. 2016;51(7):917–26. (in Japanese)

    Google Scholar 

  12. Noguchi A, Watanabe N, Ajioka Y, et al. A case of Crohn’s disease-related small bowel cancer with recurrence. Stomach Intestine. 2014;49(9):1339–45. (in Japanese)

    Google Scholar 

  13. Sugita A, Koganei K, Tatsumi K, et al. Surgical treatment of small bowel cancer complicated by Crohn’s disease. Intestine. 2015;19(4):399–404. (in Japanese)

    Google Scholar 

  14. Thomas M, Bienkowski R, Vandermeer TJ, et al. Malignant transformation in perianal fistulas of Crohn’s disease: a systematic review of the literature. J Gastrointest Surg. 2010;14:66–73.

    Article  Google Scholar 

  15. Yano Y, Matsui T, Uno H, et al. Risks and clinical features of colorectal cancer complicating Crohn’s disease in Japanese patients. J Gastroenterol Hepatol. 2008;23:1683–8.

    Article  Google Scholar 

  16. Hirano Y, Futami K, Higashi D, et al. Anorectal cancer surveillance in Crohn’s disease. J Anus Rectum Colon. 2018;2(4):145–54.

    Article  Google Scholar 

  17. Annese V, Beaugeric L, Egan L, et al. European evidence-based consensus: inflammatory bowel disease and malignancies. J Crohns Colitis. 2015;9(11):945–65.

    Article  Google Scholar 

  18. Freidman S, Rubin PH, Bodian C, et al. Screening and surveillance colonoscopy in chronic Crohn’s colitis: results of a surveillance program spanning 25years. Clin Gastroenterol Hepatol. 2008;6:993–8.

    Article  Google Scholar 

  19. Esaki M, Ikegami K, Kawachi S, et al. Characteristics of malignant diseases of the gastrointestinal tract; malignant diseases of the small intestine and colon. Stomach Intestine. 2012;47(10):1545–57. (In Japanese)

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2022 The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Futami, K. (2022). Crohn’s Disease-Associated Lower Gastrointestinal Cancer. In: Matsui, T., Iwashita, A., Matsumoto, T., Hisabe, T., Futami, K., Tanabe, H. (eds) Atlas of Inflammatory Bowel Disease-Associated Intestinal Cancer. Springer, Singapore. https://doi.org/10.1007/978-981-19-3413-1_3

Download citation

  • DOI: https://doi.org/10.1007/978-981-19-3413-1_3

  • Published:

  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-19-3412-4

  • Online ISBN: 978-981-19-3413-1

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics