Abstract
Solvents play very important role in a chemical reaction by providing a medium to solubilize the reacting components, reagents and also facilitate mass and heat transfer processes. It also affects the reaction kinetics and the stability of various reacting species and intermediates.
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References
Reichardt, C.: Solvents and solvent effects: an introduction. Org. Process Res. Dev. 11(1), 105–113 (2007)
Sheldon, R.A.: The E factor 25 years on: the rise of green chemistry and sustainability. Green Chem. 19(1), 18–43 (2017)
Rodríguez, B., Rantanen, T., Bolm, C.: Solvent-free asymmetric organocatalysis in a ball mill. Angew. Chemie 118(41), 7078–7080 (2006)
Tripathi, G., Kumar, A., Rajkhowa, S., Tiwari, V.K.: Synthesis of biologically relevant heterocyclic skeletons under solvent-free condition. In: Green Synthetic Approaches for Biologically Relevant Heterocycles, pp. 421–459. Elsevier (2021)
Tobiszewski, M., Namieśnik, J., Pena-Pereira, F.: Environmental risk-based ranking of solvents using the combination of a multimedia model and multi-criteria decision analysis. Green Chem. 19(4), 1034–1042 (2017)
Simon, M.-O., Li, C.-J.: Green chemistry oriented organic synthesis in water. Chem. Soc. Rev. 41(4), 1415–1427 (2012)
Clark, J.H., Farmer, T.J., Hunt, A.J., Sherwood, J.: Opportunities for bio-based solvents created as petrochemical and fuel products transition towards renewable resources. Int. J. Mol. Sci. 16(8), 17101–17159 (2015)
Sheldon, R.A.: Green solvents for sustainable organic synthesis: state of the art. Green Chem. 7(5), 267–278 (2005)
Yilmaz, E., Soylak, M.: Type of green solvents used in separation and preconcentration methods. In: New Generation Green Solvents for Separation and Preconcentration of Organic and Inorganic Species (2020). https://doi.org/10.1016/b978-0-12-818569-8.00005-x
Sathish, M., Silambarasan, S., Madhan, B., Rao, J.R.: Exploration of GSK’s solvent selection guide in leather industry: a CSIR-CLRI tool for sustainable leather manufacturing. Green Chem. 18(21), 5806–5813 (2016)
Alder, C.M., Hayler, J.D., Henderson, R.K., Redman, A.M., Shukla, L., Shuster, L.E., Sneddon, H.F.: Updating and further expanding GSK’s solvent sustainability guide. Green Chem. 18(13), 3879–3890 (2016)
Prat, D., Pardigon, O., Flemming, H.-W., Letestu, S., Ducandas, V., Isnard, P., Guntrum, E., Senac, T., Ruisseau, S., Cruciani, P.: Sanofi’s solvent selection guide: a step toward more sustainable processes. Org. Process Res. Dev. 17(12), 1517–1525 (2013)
Byrne, F.P., Jin, S., Paggiola, G., Petchey, T.H.M., Clark, J.H., Farmer, T.J., Hunt, A.J., McElroy, C.R., Sherwood, J.: Tools and techniques for solvent selection: green solvent selection guides. Sustain. Chem. Process 4(1), 1–24 (2016)
Bembenic, M.A.H., Clifford, C.E.B.: Subcritical water reactions of a hardwood derived organosolv lignin with nitrogen, hydrogen, carbon monoxide, and carbon dioxide gases. Energ. Fuels 26(7), 4540–4549 (2012)
Avola, S., Goettmann, F., Antonietti, M., Kunz, W.: Organic reactivity of alcohols in superheated aqueous salt solutions: an overview. New J. Chem. 36(8), 1568–1573 (2012)
Rideout, D.C., Breslow, R.: Hydrophobic acceleration of diels-alder reactions. J. Am. Chem. Soc. 102(26), 7816–7817 (1980)
Chao-Jun Li, L.C.: Organic chemistry in water. Chem. Soc. Rev. 35, 68–82 (2006)
Narayan, S., Muldoon, J., Finn, M.G., Fokin, V.V., Kolb, H.C., Sharpless, K.B.: “On Water”: unique reactivity of organic compounds in aqueous suspension. Angew. Chemie Int. Ed. 44(21), 3275–3279 (2005)
Yorimitsu, H., Nakamura, T., Shinokubo, H., Oshima, K., Omoto, K., Fujimoto, H.: Powerful solvent effect of water in radical reaction: triethylborane-induced atom-transfer radical cyclization in water. J. Am. Chem. Soc. 122(45), 11041–11047 (2000)
Huang, T., Meng, Y., Venkatraman, S., Wang, D., Li, C.-J.: Remarkable electronic effect on rhodium-catalyzed carbonyl additions and conjugated additions with arylmetallic reagents. J. Am. Chem. Soc. 123(30), 7451–7452 (2001)
Keh, C.C.K., Wei, C., Li, C.-J.: The Barbier−Grignard-type carbonyl alkylation using unactivated alkyl halides in water. J. Am. Chem. Soc. 125(14), 4062–4063 (2003)
Kobayashi, S.: Lanthanide trifluoromethanesulfonates as stable Lewis acids in aqueous media. Yb(OTf)3 catalyzed hydroxymethylation reaction of silyl enol ethers with commercial formaldehyde solution. Chem. Lett. 20(12), 2187–2190 (1991)
Wei, C., Li, C.-J.: Enantioselective direct-addition of terminal alkynes to imines catalyzed by copper (I) pybox complex in water and in toluene. J. Am. Chem. Soc. 124(20), 5638–5639 (2002)
ten Brink, G.-J., Arends, I.W.C.E., Sheldon, R.A.: Green, catalytic oxidation of alcohols in water. Science 287(5458), 1636–1639 (2000)
Uozumi, Y., Nakao, R.: Catalytic oxidation of alcohols in water under atmospheric oxygen by use of an amphiphilic resin-dispersion of a nanopalladium catalyst. Angew. Chemie 115(2), 204–207 (2003)
Noyori, R., Aoki, M., Sato, K.: Green oxidation with aqueous hydrogen peroxide. Chem. Commun. 16, 1977–1986 (2003)
Sloboda-Rozner, D., Alsters, P.L., Neumann, R.: A water-soluble and “self-assembled” polyoxometalate as a recyclable catalyst for oxidation of alcohols in water with hydrogen peroxide. J. Am. Chem. Soc. 125(18), 5280–5281 (2003)
Rodrigues, F., Canac, Y., Lubineau, A.: A convenient, one-step, synthesis of β-C-glycosidic ketones in aqueous media. Chem. Commun. 20, 2049–2050 (2000)
Welton, T.: Ionic liquids: a brief history. Biophys. Rev. 10(3), 691–706 (2018)
Keskin, S., Kayrak-Talay, D., Akman, U., Hortaçsu, Ö.: A review of ionic liquids towards supercritical fluid applications. J. Supercrit. Fluids 43(1), 150–180 (2007)
Jessop, P.G.: Searching for green solvents. Green Chem. 13(6), 1391–1398 (2011)
Keskin, S., Kayrak-Talay, D., Akman, U., Hortaçsu, O.: A review of ionic liquids towards supercritical fluid applications. J. Supercrit. Fluids 43, 150–180 (2007)
Yang, B., Zhang, Q., Fei, Y., Zhou, F., Wang, P., Deng, Y.: Biodegradable betaine-based aprotic task-specific ionic liquids and their application in efficient SO2 absorption. Green Chem. 17(7), 3798–3805 (2015)
Eilmes, A., Kubisiak, P.: Quantum-chemical and molecular dynamics study of M+[TOTO]− (M = Li, Na, K) ionic liquids. J. Phys. Chem. B 117(41), 12583–12592 (2013)
Plaumann, H.: Switchable polarity solvents: are they green? Phys. Sci. Rev. 2(3), 27–30 (2017)
Phan, L., Brown, H., White, J., Hodgson, A., Jessop, P.G.: Soybean oil extraction and separation using switchable or expanded solvents. Green Chem. 11(1), 53–59 (2009)
Vanderveen, J.R., Durelle, J., Jessop, P.G.: Design and evaluation of switchable-hydrophilicity solvents. Green Chem. 16(3), 1187–1197 (2014)
Peach, J., Eastoe, J.: Supercritical carbon dioxide: a solvent like no other. Beilstein J. Org. Chem. 10(1), 1878–1895 (2014)
De Marco, I., Riemma, S., Iannone, R.: Supercritical carbon dioxide decaffeination process: a life cycle assessment study. Chem. Eng. Trans. 57, 1699–1704 (2017)
Pinelo, M., Ruiz-Rodríguez, A., Sineiro, J., Señoráns, F.J., Reglero, G., Núñez, M.J.: Supercritical fluid and solid-liquid extraction of phenolic antioxidants from grape pomace: a comparative study. Eur. Food Res. Technol. 226(1), 199–205 (2007)
Villanueva Bermejo, D., Angelov, I., Vicente, G., Stateva, R.P., Rodriguez García-Risco, M., Reglero, G., Ibañez, E., Fornari, T.: Extraction of thymol from different varieties of thyme plants using green solvents. J. Sci. Food Agric. 95(14), 2901–2907 (2015)
Lu, Y., Mu, B., Zhu, B., Wu, K., Gou, Z., Li, L., Cui, L., Liang, N.: Comparison of supercritical fluid extraction and liquid solvent extraction on antitumor diterpenoid from Pteris semipinnata L.. Sep. Sci. Technol. 47(16), 2436–2443 (2012)
Jessop, P.G., Ikariya, T., Noyori, R.: Homogeneous catalytic hydrogenation of supercritical carbon dioxide. Nature 368(6468), 231–233 (1994)
Jessop, P.G., Hsiao, Y., Ikariya, T., Noyori, R.: Catalytic production of dimethylformamide from supercritical carbon dioxide. J. Am. Chem. Soc. 116(19), 8851–8852 (1994)
Jessop, P.G., Hsiao, Y., Ikariya, T., Noyori, R.: Homogeneous catalysis in supercritical fluids: hydrogenation of supercritical carbon dioxide to formic acid, alkyl formates, and formamides. J. Am. Chem. Soc. 118(2), 344–355 (1996)
Burk, M.J., Feng, S., Gross, M.F., Tumas, W.: Asymmetric catalytic hydrogenation reactions in supercritical carbon dioxide. J. Am. Chem. Soc. 117(31), 8277–8278 (1995)
Xiao, J., Nefkens, S.C.A., Jessop, P.G., Ikariya, T., Noyori, R.: Asymmetric hydrogenation of α,β-unsaturated carboxylic acids in supercritical carbon dioxide. Tetrahedron Lett. 37(16), 2813–2816 (1996)
Hu, Y., Birdsall, D.J., Stuart, A.M., Hope, E.G., Xiao, J.: Ruthenium-catalysed asymmetric hydrogenation with fluoroalkylated binap ligands in supercritical CO2. J. Mol. Catal. A Chem. 219(1), 57–60 (2004)
Lyubimov, S.E., Rastorguev, E.A., Petrovskii, P.V., Kelbysheva, E.S., Loim, N.M., Davankov, V.A.: Iridium-catalyzed asymmetric hydrogenation of imines in supercritical carbon dioxide using phosphite-type ligands. Tetrahedron Lett. 52(12), 1395–1397 (2011)
Berthod, M., Mignani, G., Lemaire, M.: New perfluoroalkylated BINAP usable as a ligand in homogeneous and supercritical carbon dioxide asymmetric hydrogenation. Tetrahedron Asym. 15(7), 1121–1126 (2004)
Gava, R., Olmos, A., Noverges, B., Varea, T., Álvarez, E., Belderrain, T.R., Caballero, A., Asensio, G., Pérez, P.J.: Discovering copper for methane C–H bond functionalization. ACS Catal. 5(6), 3726–3730 (2015)
Zhang, W., He, X., Ren, B., Jiang, Y., Hu, Z.: Cu(OAc)2·H2O—an efficient catalyst for Huisgen-click reaction in supercritical carbon dioxide. Tetrahedron Lett. 56(19), 2472–2475 (2015)
López-Periago, A.M., Vega, A., Subra, P., Argemí, A., Saurina, J., García-González, C.A., Domingo, C.: Supercritical CO2 processing of polymers for the production of materials with applications in tissue engineering and drug delivery. J. Mater. Sci. 43(6), 1939–1947 (2008)
Liu, X., Coutelier, O., Harrisson, S., Tassaing, T., Marty, J.-D., Destarac, M.: Enhanced solubility of polyvinyl esters in ScCO2 by means of vinyl trifluorobutyrate monomer. ACS Macro Lett. 4(1), 89–93 (2015)
Chakraborty, S., Colón, Y.J., Snurr, R.Q., Nguyen, S.T.: Hierarchically porous organic polymers: highly enhanced gas uptake and transport through templated synthesis. Chem. Sci. 6(1), 384–389 (2015)
Maleki, H., Durães, L., Portugal, A.: Synthesis of mechanically reinforced silica aerogels via surface-initiated reversible addition-fragmentation chain transfer (RAFT) polymerization. J. Mater. Chem. A 3(4), 1594–1600 (2015)
Kuang, T.-R., Mi, H.-Y., Fu, D.-J., Jing, X., Chen, B., Mou, W.-J., Peng, X.-F.: Fabrication of poly (lactic acid)/graphene oxide foams with highly oriented and elongated cell structure via unidirectional foaming using supercritical carbon dioxide. Ind. Eng. Chem. Res. 54(2), 758–768 (2015)
Zhao, J., Liu, Z., Li, H., Hu, W., Zhao, C., Zhao, P., Shi, D.: Development of a highly active electrocatalyst via ultrafine Pd nanoparticles dispersed on pristine graphene. Langmuir 31(8), 2576–2583 (2015)
Jiménez, C., Garcia, J., Camarillo, R., Martínez, F., Rincón, J.: Electrochemical CO2 reduction to fuels using Pt/CNT catalysts synthesized in supercritical medium. Energ. Fuels 31(3), 3038–3046 (2017)
Cid, M.V.F., Van Spronsen, J., Van der Kraan, M., Veugelers, W.J.T., Woerlee, G.F., Witkamp, G.J.: Excellent dye fixation on cotton dyed in supercritical carbon dioxide using fluorotriazine reactive dyes. Green Chem. 7(8), 609–616 (2005)
Abou Elmaaty, T., Abd El-Aziz, E.: Supercritical carbon dioxide as a green media in textile dyeing: a review. Text. Res. J. 88(10), 1184–1212 (2018)
Xiao, H., Zhao, T., Li, C.-H., Li, M.-Y.: Eco-friendly approaches for dyeing multiple type of fabrics with cationic reactive dyes. J. Clean. Prod. 165, 1499–1507 (2017)
Zhang, Y.-Q., Wei, X.-C., Long, J.-J.: Ecofriendly synthesis and application of special disperse reactive dyes in waterless coloration of wool with supercritical carbon dioxide. J. Clean. Prod. 133, 746–756 (2016)
DeSimone, J.M., Tumas, W.: Green Chemistry Using Liquid and Supercritical Carbon Dioxide. Oxford University Press (2003)
Lee, W., Kuan, W.: Miscanthus as cellulosic biomass for bioethanol production. Biotechnol. J. 10(6), 840–854 (2015)
Beringer, T.I.M., Lucht, W., Schaphoff, S.: Bioenergy production potential of global biomass plantations under environmental and agricultural constraints. GCB Bioenerg. 3(4), 299–312 (2011)
Pace, V., Hoyos, P., Castoldi, L., Dominguez de Maria, P., Alcántara, A.R.: 2‐methyltetrahydrofuran (2‐MeTHF): a biomass‐derived solvent with broad application in organic chemistry. ChemSusChem 5(8), 1369–1379 (2012)
Brandt, A., Gräsvik, J., Hallett, J.P., Welton, T.: Deconstruction of lignocellulosic biomass with ionic liquids. Green Chem. 15(3), 550–583 (2013)
Farrán, A., Cai, C., Sandoval, M., Xu, Y., Liu, J., Hernáiz, M.J., Linhardt, R.J.: Green solvents in carbohydrate chemistry: from raw materials to fine chemicals. Chem. Rev. 115(14), 6811–6853 (2015)
Onda, A., Ochi, T., Yanagisawa, K.: Selective hydrolysis of cellulose into glucose over solid acid catalysts. Green Chem. 10, 1033–1037 (2008)
Ciriminna, R., Lomeli-Rodriguez, M., Cara, P.D., Lopez-Sanchez, J.A., Pagliaro, M.: Limonene: a versatile chemical of the bioeconomy. Chem. Commun. 50(97), 15288–15296 (2014)
Antonucci, V., Coleman, J., Ferry, J.B., Johnson, N., Mathe, M., Scott, J.P., Xu, J.: Toxicological assessment of 2-methyltetrahydrofuran and cyclopentyl methyl ether in support of their use in pharmaceutical chemical process development. Org. Process Res. Dev. 15(4), 939–941 (2011)
Liguori, F., Moreno-Marrodan, C., Barbaro, P.: Environmentally friendly synthesis of γ-valerolactone by direct catalytic conversion of renewable sources. ACS Catal. 5(3), 1882–1894 (2015)
Sherwood, J., Constantinou, A., Moity, L., McElroy, C.R., Farmer, T.J., Duncan, T., Raverty, W., Hunt, A.J., Clark, J.H.: Dihydrolevoglucosenone (Cyrene) as a bio-based alternative for dipolar aprotic solvents. Chem. Commun. 50(68), 9650–9652 (2014)
Botella, L., Nájera, C.: Controlled mono and double heck reactions in water catalyzed by an oxime-derived palladacycle. Tetrahedron Lett. 45(9), 1833–1836 (2004)
Sarmah, M., Mondal, M., Bora, U.: Agro-waste extract based solvents: emergence of novel green solvent for the design of sustainable processes in catalysis and organic chemistry. ChemistrySelect 2(18), 5180–5188 (2017)
Yara-Varón, E., Li, Y., Balcells, M., Canela-Garayoa, R., Fabiano-Tixier, A.-S., Chemat, F.: Vegetable oils as alternative solvents for green oleo-extraction, purification and formulation of food and natural products. Molecules 22(9), 1474 (2017)
Menges, N., Şahin, E.: Metal-and base-free combinatorial reaction for C-acylation of 1,3-diketo compounds in vegetable oil: the effect of natural oil. ACS Sustain. Chem. Eng. 2(2), 226–230 (2014)
García, J.I., García-Marín, H., Pires, E.: Glycerol based solvents: synthesis, properties and applications. Green Chem. 16(3), 1007–1033 (2014)
Becker, L.C., Bergfeld, W.F., Belsito, D.V., Hill, R.A., Klaassen, C.D., Liebler, D.C., Marks, J.G., Jr., Shank, R.C., Slaga, T.J., Snyder, P.W.: Safety assessment of glycerin as used in cosmetics. Int. J. Toxicol. 38(3), 6S-22S (2019)
Gu, Y., Barrault, J., Jerome, F.: Glycerol as an efficient promoting medium for organic reactions. Adv. Synth. Catal. 350(13), 2007–2012 (2008)
Gu, Y., Jérôme, F.: Glycerol as a sustainable solvent for green chemistry. Green Chem. 12(7), 1127–1138 (2010)
Li, M., Chen, C., He, F., Gu, Y.: Multicomponent reactions of 1,3-cyclohexanediones and formaldehyde in glycerol: stabilization of paraformaldehyde in glycerol resulted from using dimedone as substrate. Adv. Synth. Catal. 352(2–3), 519–530 (2010)
Tan, J.-N., Li, M., Gu, Y.: Multicomponent reactions of 1,3-disubstituted 5-pyrazolones and formaldehyde in environmentally benign solvent systems and their variations with more fundamental substrates. Green Chem. 12(5), 908–914 (2010)
Radatz, C.S., Silva, R.B., Perin, G., Lenardão, E.J., Jacob, R.G., Alves, D.: Catalyst-free synthesis of benzodiazepines and benzimidazoles using glycerol as recyclable solvent. Tetrahedron Lett. 52(32), 4132–4136 (2011)
Kumar, T.A., Devi, B.R., Dubey, P.K.: Simple, facile and complete green synthesis of N-alkyl-2-styrylbenzimidazoles using glycerol and PEG-600 as green solvents. Der. Chem. Sin. 4, 116–121 (2013)
Bachhav, H.M., Bhagat, S.B., Telvekar, V.N.: Efficient protocol for the synthesis of quinoxaline, benzoxazole and benzimidazole derivatives using glycerol as green solvent. Tetrahedron Lett. 52(43), 5697–5701 (2011)
Wolfson, A., Dlugy, C., Tavor, D., Blumenfeld, J., Shotland, Y.: Baker’s yeast catalyzed asymmetric reduction in glycerol. Tetrahedron Asym. 17(14), 2043–2045 (2006)
Andrade, L.H., Piovan, L., Pasquini, M.D.: Improving the enantioselective bioreduction of aromatic ketones mediated by aspergillus Terreus and Rhizopus Oryzae: The role of glycerol as a co-solvent. Tetrahedron Asym. 20(13), 1521–1525 (2009)
Taketomi, S., Asano, M., Higashi, T., Shoji, M., Sugai, T.: Chemo-enzymatic route for (R)-terbutaline hydrochloride based on microbial asymmetric reduction of a substituted α-chloroacetophenone derivative. J. Mol. Catal. B Enzym. 84, 83–88 (2012)
Khatri, P.K., Jain, S.L.: Glycerol ingrained copper: an efficient recyclable catalyst for the N-arylation of amines with aryl halides. Tetrahedron Lett. 54(21), 2740–2743 (2013)
Silveira, C.C., Mendes, S.R., Líbero, F.M., Lenardão, E.J., Perin, G.: Glycerin and CeCl3 · 7H2O: a new and efficient recyclable medium for the synthesis of bis(indoly) methanes. Tetrahedron Lett. 50(44), 6060–6063 (2009)
Delample, M., Villandier, N., Douliez, J.-P., Camy, S., Condoret, J.-S., Pouilloux, Y., Barrault, J., Jérôme, F.: Glycerol as a cheap, safe and sustainable solvent for the catalytic and regioselective β,β-diarylation of acrylates over palladium nanoparticles. Green Chem. 12(5), 804–808 (2010)
Cabrera, D.M.L., Libero, F.M., Alves, D., Perin, G., Lenardao, E.J., Jacob, R.G.: Glycerol as a recyclable solvent in a microwave-assisted synthesis of disulfides. Green Chem. Lett. Rev. 5(3), 329–336 (2012)
Chung, W.J., Baskar, C., Chung, D.G., Han, M.D., Lee, C.H.: Catalytic transfer hydrogenation of carboxylic acids to their corresponding alcohols by using glycerol as hydrogen donor. Repub Korean Kongkae Taeho Kongbo (2012)
Gladysz, J.A., Curran, D.P., Horváth, I.T.: Handbook of Fluorous Chemistry. Wiley (2006)
Horváth, I.T., Kiss, G., Cook, R.A., Bond, J.E., Stevens, P.A., Rábai, J., Mozeleski, E.J.: Molecular engineering in homogeneous catalysis: one-phase catalysis coupled with biphase catalyst separation. The fluorous-soluble HRh(CO){P[CH2CH2(CF2)5CF3]3}3 hydroformylation system. J. Am. Chem. Soc. 120(13), 3133–3143 (1998)
Horváth, I.T., Rábai, J.: Facile catalyst separation without water: fluorous biphase hydroformylation of olefins. Science 266(5182), 72–75 (1994)
da Costa, R.C., Gladysz, J.A.: Syntheses and reactivity of analogues of Grubbs’ second generation metathesis catalyst with fluorous phosphines: a new phase-transfer strategy for catalyst activation. Adv. Synth. Catal. 349(1–2), 243–254 (2007)
Shen, M.-G., Cai, C., Yi, W.-B.: Yb[N(SO2C8F17)2]3-catalyzed allylation of 1,3-dicarbonyl compounds with allylic alcohols in a fluorous biphase system. J. Fluor. Chem. 130(6), 595–599 (2009)
Yamada, S., Gavryushin, A., Knochel, P.: Convenient electrophilic fluorination of functionalized aryl and heteroaryl magnesium reagents. Angew. Chemie 122(12), 2261–2264 (2010)
Zhou, T., Xiao, X., Li, G., Cai, Z.: Study of polyethylene glycol as a green solvent in the microwave-assisted extraction of flavone and coumarin compounds from medicinal plants. J. Chromatogr. A 1218(23), 3608–3615 (2011)
Corma, A., García, H., Leyva, A.: Polyethyleneglycol as scaffold and solvent for reusable CC coupling homogeneous Pd catalysts. J. Catal. 240(2), 87–99 (2006)
Namboodiri, V.V., Varma, R.S.: Microwave-accelerated Suzuki cross-coupling reaction in polyethylene glycol (PEG). Green Chem. 3(3), 146–148 (2001)
Chandrasekhar, S., Narsihmulu, C., Sultana, S.S., Reddy, N.R.: Poly(ethylene glycol) (PEG) as a reusable solvent medium for organic synthesis. Application in the heck reaction. Org. Lett. 4(25), 4399–4401(2002)
Zhou, W., Wang, K., Wang, J.: Atom-efficient, palladium-catalyzed Stille coupling reactions of tetraphenylstannane with aryl iodides or aryl bromides in polyethylene glycol 400 (PEG-400). Adv. Synth. Catal. 351(9), 1378–1382 (2009)
Shi, S., Zhang, Y.: Pd(OAc)2-catalyzed fluoride-free cross-coupling reactions of arylsiloxanes with aryl bromides in aqueous medium. J. Org. Chem. 72(15), 5927–5930 (2007)
Corma, A., García, H., Leyva, A.: Comparison between polyethylenglycol and imidazolium ionic liquids as solvents for developing a homogeneous and reusable palladium catalytic system for the Suzuki and Sonogashira coupling. Tetrahedron 61(41), 9848–9854 (2005)
Kerru, N., Gummidi, L., Maddila, S., Jonnalagadda, S.B.: Polyethylene glycol (PEG-400) mediated one-pot green synthesis of 4,7-dihydro-2H-pyrazolo[3,4-b]pyridines under catalyst-free conditions. ChemistrySelect 5(40), 12407–12410 (2020)
Kumar, R., Rawat, D., Adimurthy, S.: Polyethylene glycol (PEG-400) as methylene spacer and green solvent for the synthesis of heterodiarylmethanes under metal-free conditions. Eur. J. Org. Chem. 2020(23), 3499–3507 (2020)
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Tiwari, V.K., Kumar, A., Rajkhowa, S., Tripathi, G., Singh, A.K. (2022). Green Solvents: Application in Organic Synthesis. In: Green Chemistry. Springer, Singapore. https://doi.org/10.1007/978-981-19-2734-8_3
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