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Preparation and Characterization of Polymer Biocomposite 3D Mat for Bone Tissue Regeneration

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Polymeric Biomaterials and Bioengineering

Part of the book series: Lecture Notes in Bioengineering ((LNBE))


Bone scaffold is a three-dimensional matrix which stimulates the attachment and proliferation of osteoinducible cells on its surface. Use of scaffolds is the standard procedure to treat skeletal fractals, replace or regenerate the damaged/lost bone tissues. However, reproducing the complete features of the bone morphology, strength and porosity is a challenging task. The present study endeavors toward the preparation and bioactive studies of PCL/bioactive glass electrospun three-dimensional (3D) mat. The 3D mat was fabricated using eletrospinning process. To prepare biocomposites, 45S5 bioglass (1 wt%) prepared by sol–gel method was mixed with PCL (8 wt%) using chloroform and ethanol as a solvent, which has dispersibility and spinnability. The physicochemical characterization using X-ray diffraction and Fourier transform infrared spectroscopy confirmed the presence of bioglass in the biocomposite fibers. The scaffold structure was evaluated using scanning electron microscopy, which reveals the porous nature with an average fiber diameter of 116 ± 40 nm. In vitro studies revealed the mineralization ability of the prepared fibrous 3D mat in stimulated body fluid (SBF) under static conditions. The biocomposite scaffold exhibits higher calcium phosphate formation and higher degradation rate. These results indicate that PCL/BG biocomposite scaffolds as a favorable substance for bone tissue regeneration applications

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The authors are thankful to the Department of Science and Technology (DST) Science of Equity Empowerment and Development (SEED), CIPET:IPT, Chennai, and Material Development Lab, CIPET:SARP-ARSTPS, Chennai, for providing the necessary supports to carry out above research work.

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Ramar, G., Periyasamy, B.K., Joseph Bensingh, R., Nayak, S.K. (2022). Preparation and Characterization of Polymer Biocomposite 3D Mat for Bone Tissue Regeneration. In: Gupta, B., Jawaid, M., Kaith, B.S., Rattan, S., Kalia, S. (eds) Polymeric Biomaterials and Bioengineering. Lecture Notes in Bioengineering. Springer, Singapore.

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