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Fresh Frozen Plasma

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Transfusion Practice in Clinical Neurosciences

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Abstract

Fresh frozen plasma, though a commonly prescribed hemostatic agent, has proven beneficial effect in limited clinical conditions. FFP is rich in fibrinogen, albumin, protein C, protein S, antithrombin, and tissue factor pathway inhibitor. The processes of FFP preparation, pathogen inactivation, storage, and handling are important determinants of FFP quality. A standard dose of 10 to 20 mL/kg raises factor levels by around 20%. FFP is produced from whole blood by centrifugation or by apheresis. While identical ABO blood group plasma must be used as the first choice, ABO non-identical plasma might be acceptable in emergency situations. While most indications for FFP transfusion are not clear-cut, there is broad general consensus that appropriate use of AFFP/FP is limited to clinically significant bleeding due to a deficiency of one or more plasma coagulation factors. Adverse effects related to FFP transfusion are similar to those associated with other blood products. This chapter elaborates on all these aspects of FFP including a brief overview of some historical aspects as well.

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Authors and Affiliations

  1. Department of Neuroanaesthesia and Neurocritical Care, Medanta The Medicity, Gurugram, India

    Barkha Bindu & Vasudha Singhal

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  1. Barkha Bindu
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  2. Vasudha Singhal
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Corresponding author

Correspondence to Vasudha Singhal .

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Editors and Affiliations

  1. Neuroanaesthesiology and Critical Care, All India Institute of Medical Sciences, New Delhi, Delhi, India

    Hemanshu Prabhakar

  2. Anesthesiology and Intensive Care, G B Pant Institute of Medical Education and Research, New Delhi, Delhi, India

    Monica S Tandon

  3. Neuroanaesthesiology and Critical Care, All India Institute of Medical Sciences, New Delhi, Delhi, India

    Indu Kapoor

  4. Neuroanaesthesiology and Critical Care, All India Institute of Medical Sciences, New Delhi, Delhi, India

    Charu Mahajan

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Bindu, B., Singhal, V. (2022). Fresh Frozen Plasma. In: Prabhakar, H., S Tandon, M., Kapoor, I., Mahajan, C. (eds) Transfusion Practice in Clinical Neurosciences. Springer, Singapore. https://doi.org/10.1007/978-981-19-0954-2_27

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  • DOI: https://doi.org/10.1007/978-981-19-0954-2_27

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  • Publisher Name: Springer, Singapore

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  • Online ISBN: 978-981-19-0954-2

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