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Synthetic Approach of Quinazolines Candidates

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N-Heterocycles

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Abstract

Quinazolines belong to the heterocyclic chemistry and are also known as 1,3-diazanaphthalene. The skeleton is composed of two six-membered aromatic rings that are fused to each other’s and two nitrogen atoms are present at 1 and 3 positions on the skeleton that is why it is also called 1,3-diazanaphthalene. The presence of these two nitrogen atoms in quinazoline increases the importance in the pharmaceutical as well as in biological reactions. The synthesis methods have been reported to prepare quinazoline by aminobenzoketone, o-aminobenzohydrazide, aminobenzonitrile, aminoacetophenone, and aminobenzamide under different conditions, but the reaction of aromatic aldehyde and anthranilic acid is the very common method for the preperstion of the quinazoline. As time goes passed away, the synthesis methods are reported in metal-free and solvent-free conditions which are dominated over the old methods. In this chapter, we describe the synthesis of quinazoline under different conditions like metal catalysts, reagents, solvent-free and under microwave radiation through nucleophilic substitution reaction, condensation, aromatization, etc. In biological sciences, quinazoline derivatives have got an important place due to their ability to bind to different target sites and subsequent discovery of many drug structures.

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Authors and Affiliations

  1. Department of Chemistry, Dr. Shakuntala Misra National Rehabilitation University, Lucknow, 226017, India

    Vinay Kumar Singh & Mohd. Faheem

  2. Department of Chemistry, Babasaheb Bhimrao Ambedkar University, Lucknow, 226025, India

    Anjani Kumar Tiwari

Authors
  1. Vinay Kumar Singh
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  2. Anjani Kumar Tiwari
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  3. Mohd. Faheem
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Corresponding author

Correspondence to Vinay Kumar Singh .

Editor information

Editors and Affiliations

  1. Department of Chemistry, Mody University of Science and Technology, Lakshmangarh, India

    Keshav Lalit Ameta

  2. Chemistry, Shri Ramswaroop Memorial University, Lucknow, Uttar Pradesh, India

    Ravi Kant

  3. Chemistry, University of Insubria, Varese, Italy

    Andrea Penoni

  4. Science and High Technology, University of Insubria, Varese, Italy

    Angelo Maspero

  5. Science and High Technology, University of Insubria, Varese, Italy

    Luca Scapinello

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Singh, V.K., Tiwari, A.K., Faheem, M. (2022). Synthetic Approach of Quinazolines Candidates. In: Ameta, K.L., Kant, R., Penoni, A., Maspero, A., Scapinello, L. (eds) N-Heterocycles. Springer, Singapore. https://doi.org/10.1007/978-981-19-0832-3_8

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