Skip to main content

Historical Perspectives of Musculoskeletal Tuberculosis

  • Chapter
  • First Online:
Tuberculosis of the Spine

Abstract

The modern strain of Mycobacterium tuberculosis might have appeared 20,000–15,000 years ago. India and China account for the first written description of tuberculosis around 3300 and 2300 years ago, respectively. In Ancient Greece, Hippocrates (400–300 BC) described Phthisis or Consumption as a fatal disease. The term “Pott’s disease” was coined by Sir Percivall Pott, a British surgeon in 1779. Johann Lukas Schönlein first used the term “tuberculosis” in 1839. Tubercle bacillus was first isolated by Robert Koch. The sanatorium treatment was first described in 1854 by Hermann Brehmer. Menard (1895) described “costo-transversectomy.” This approach was further developed by Griffiths, Roaf, and Seddon. Norman Capener (1933) developed the classical “anterolateral decompression.” The Frenchmen, Calmette, and Guérin developed BCG vaccine. The first successful Anti-tubercular drug Streptomycin was discovered by Selman Waksman in September 1943. Hodgson in 1960 popularized “The Hong Kong Surgery.” Tuli from India in 1975 published successful results of the “middle path regimen.” In recent years, “all posterior” approach to the tubercular spine has become popular. In the 1970s and 1980s with the rise of the AIDS epidemic, tuberculosis re-emerged as a potential threat to humanity. The emergence Drug-Resistant strains have led to the complete abrogation of single or dual drug therapy. Multidrug therapies for a prolonged period are the norm now. New antitubercular drugs are being developed, e.g., Bedaquiline, Delamanid, and Pretomanid.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 159.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Similar content being viewed by others

References

  1. Bazin H. Vaccination: A history. Montrouge: John Libbey Eurotext; 2011.

    Google Scholar 

  2. Hayman J. Mycobacterium ulcerans: an infection from Jurassic time? Lancet. 1984;2(8410):1015–6.

    Article  CAS  PubMed  Google Scholar 

  3. Steele JH, Ranney AF. Animal tuberculosis. Am Rev Tuberc. 1958;77:908.

    CAS  PubMed  Google Scholar 

  4. Gutierrez MC, Brisse S, Brosch R, Fabre M, Omaïs B, Marmiesse M, Supply P, Vincent V. Ancient origin and gene mosaicism of the progenitor of Mycobacterium tuberculosis. PLoS Pathog. 2005;1(1):e5.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  5. Kapur V, Whittam TS, Musser JM. Is Mycobacterium tuberculosis 15,000 years old? J Infect Dis. 1994;170(5):1348–9.

    Article  CAS  PubMed  Google Scholar 

  6. Brosch R, Gordon SV, Marmiesse M, Brodin P, Buchrieser C, Eiglmeier K, Garnier T, Gutierrez C, Hewinson G, Kremer K, Parsons LM, Pym AS, Samper S, van Soolingen D, Cole ST. A new evolutionary scenario for the Mycobacterium tuberculosis complex. Proc Natl Acad Sci U S A. 2002;99(6):3684–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Rothschild BM, Martin LD, Lev G, et al. Mycobacterium tuberculosis complex DNA from an extinct bison dated 17,000 years before the present. Clin Infect Dis. 2001;33:305–11.

    Article  CAS  PubMed  Google Scholar 

  8. Kappelman J, Alcicek MC, Kazanci N, Schultz M, Ozkul M, Sen S. First Homo erectus from Turkey and implications for migrations into temperate Eurasia. Am J Phys Anthropol. 2008;135:110–6.

    Article  PubMed  Google Scholar 

  9. Ayvazian LF. History of tuberculosis. In: Reichman LB, Hershfield, editors. Tuberculosis. New York: Dekker; 1993.

    Google Scholar 

  10. Morse D, Brothwell DR, Ucko PJ. Tuberculosis in ancient Egypt. Am Rev Respir Dis. 1964;90:524–41.

    CAS  PubMed  Google Scholar 

  11. Zimmerman MR, Bull NY. Pulmonary and osseous tuberculosis in an Egyptian mummy. Acad Med. 1979;55(6):604–8.

    CAS  Google Scholar 

  12. Allison MJ, Mendoza D, Pezzia A. Documentation of a case of tuberculosis in Pre-Columbian America. Am Rev Respir Dis. 1973;107(6):985–91.

    CAS  PubMed  Google Scholar 

  13. Arriaza BT, Salo W, Aufderheide AC, Holcomb TA. Pre-Columbian tuberculosis in northern Chile: molecular and skeletal evidence. Am J Phys Anthropol. 1995;98(1):37–45.

    Article  CAS  PubMed  Google Scholar 

  14. Dubos R. The romance of death. Am Lung Assoc Bull. 1982;68:5–6.

    Google Scholar 

  15. Cave AJE. The evidence for the incidence of tuberculosis in ancient Egypt. Br J Tuberc. 1939;33:142–52.

    Article  Google Scholar 

  16. Brown L. The story of clinical pulmonary tuberculosis. Baltimore MD; 1941.

    Book  Google Scholar 

  17. Yeager RL. Opening remarks. Ann N Y Acad Sci. 1963;106:3–4.

    Article  Google Scholar 

  18. Bick KM. Classics of Orthopaedics. Philadelphia, PA: JB Lippincott Co; 1976.

    Google Scholar 

  19. Duraiswami PK, Tuli SM. 5000 years of orthopaedics in India. Clin Orthop Relat Res. 1971;75:269–80.

    Article  CAS  PubMed  Google Scholar 

  20. Daniel VS, Daniel TM. Old Testament biblical references to tuberculosis. Clin Infect Dis. 1999;29(6):1557–8.

    Article  CAS  PubMed  Google Scholar 

  21. Hippocrates (460-370 BCE). Book 1–Of the epidemics. In: Adams F, editor. The genuine works of Hippocrates. London: The Sydenham Society; 1849.

    Google Scholar 

  22. Murray JF, Rieder HL, Finley-Croswhite A. The King’s Evil and the Royal Touch: the medical history of scrofula. Int J Tuberc Lung Dis. 2016 Jun;20(6):713–6.

    Article  PubMed  Google Scholar 

  23. Sabbatani S. Historical insights into tuberculosis. Girolamo Fracastoro’s intuition on the transmission of tuberculosis and his opponents. History of an idea. Infez Med. 2004;12(4):284–91.

    PubMed  Google Scholar 

  24. Saeed BW. Malignant tuberculosis. J Ayub Med Coll Abbottabad. 2006;18(3):1–2.

    PubMed  Google Scholar 

  25. Daniel TM. Captain of death: the story of tuberculosis. Rochester, NY: University of Rochester Press; 1997.

    Google Scholar 

  26. Daniel TM. Pioneers in Medicine and their Impact on Tuberculosis. Rochester, NY: University of Rochester Press; 2000. pp. 4, 29, 46-48, 50-51, 74-76

    Google Scholar 

  27. Dormandy T. The White Death: a history of tuberculosis. London: The Hambledon press; 1999. pp. 2, 4, 13, 34-36, 73-84, 92-94, 101-104, 129-137, 147, 392

    Google Scholar 

  28. Garrison FH. An introduction to the history of medicine. Philadelphia & London: W B Saunders & Co; 1921. pp. 109, 288, 411-413, 616

    Google Scholar 

  29. Major RH. Classic descriptions of disease. Springfield, USA: Charles C Thomas; 1932. pp. 49-56, 56-57, 58-61, 61-62

    Google Scholar 

  30. Daniel TM. The history of tuberculosis. Respir Med. 2006;100(11):1862–70.

    Article  PubMed  Google Scholar 

  31. Segen JC. The dictionary of modern medicine. Park Ridge, NJ: Parthenon; 1992. p. 783.

    Google Scholar 

  32. Villemin JA. Etudes sur la tuberculose. Paris: Bailliere; 1868.

    Google Scholar 

  33. Gradmann C. Robert Koch and the pressures of scientific research: tuberculosis and tuberculin. Med Hist. 2001;45(1):1–32.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  34. Bartolozzi G. Vaccini e vaccinazioni. Terza edizione. Milano: Elsevier; 2012.

    Google Scholar 

  35. Ziehl F. Zur F€arbung des tuberkelbacillus. Dtsch Med Wochenschr. 1882;8:451.

    Article  Google Scholar 

  36. Guidi G. Chirurgia è graeco latinum conversa. Paris: Petrus Galterius; 1544. p. 552.

    Google Scholar 

  37. Daniel TM. Hermann Brehmer and the origins of tuberculosis sanatoria. Int J Tuberc Lung Dis. 2011;15(2):161–2.

    CAS  PubMed  Google Scholar 

  38. Jones R, Lovett RW. Orthopaedic surgery. London, UK: Oxford Medical Publications; 1923.

    Google Scholar 

  39. Dobson J. Tuberculosis of spine. J Bone Joint Surg Br. 1951;33:517–31.

    Article  PubMed  Google Scholar 

  40. Fellander M. Radical operation in tuberculosis of the spine. Acta Orthop Scand Suppl. 1955;19:1–117.

    Article  CAS  PubMed  Google Scholar 

  41. Girdlestone GR. Modern trends in orthopaedics. Series I. London, UK: Butterworth and Co; 1950.

    Google Scholar 

  42. Seddon HJ. Pott’s paraplegia, prognosis and treatment. Br J Surg. 1935;22:769–99.

    Article  Google Scholar 

  43. Chipault A. Etudes de chirugie medullaire. Historique, chirugie operatoire, traitement. Paris: F. Alcan; 1894.

    Google Scholar 

  44. Menard V. Cause of paraplegia in Potts’s disease. Rev Orthop. 1894;5:47–64.

    Google Scholar 

  45. Griffiths DL. Tuberculosis of bones and joints: modern practice in tuberculosis, vol. II. London, UK: Butterworth and Co; 1952. p. 302–33.

    Google Scholar 

  46. Roaf R. Tuberculosis of the spine. J Bone Joint Surg Br. 1958;40:3–5.

    Article  PubMed  Google Scholar 

  47. Roaf R, Kirkaldy-Willis WH, Cathro AJM. Surgical treatment of bone and joints tuberculosis. Edinburgh, UK: E and S Livingstone; 1959.

    Google Scholar 

  48. Seddon HJ. Pott’s paraplegia. In: Platt SH, editor. Modern trends in orthopaedics. Series II. London, UK: Butterworth and Co; 1956. p. 230–4.

    Google Scholar 

  49. Capener N. Vertebral tuberculosis and paraplegia. J Bone Joint Surg Br. 1967;49(4):605–6.

    Article  CAS  PubMed  Google Scholar 

  50. Calot T. Sur le meilleur traitment localdes tuberculoses doses, articulations et ganglions lymphatique. Acta Chir Scand. 1930;67:206–26.

    Google Scholar 

  51. Albee FH. Transplantation of a portion of the tibia into the spine for Pott’s disease: a preliminary report. JAMA. 1911;57:885–6.

    Article  Google Scholar 

  52. Hibbs RA, Risser JC. Treatment of vertebral tuberculosis by fusion operation. JAMA. 1918;71:1372.

    Article  Google Scholar 

  53. Brittain HA. Architectural principles in arthrodesis. 2nd ed. Edinburgh, UK: Livingstone; 1952.

    Google Scholar 

  54. Mercer W. Then and now: the history of skeletal tuberculosis. J R Coll Surg Edinb. 1964;9:243–54.

    Google Scholar 

  55. Bochalli R. Die Entwicklung der Tuberkuloseforschung in der Zeit von 1878 bis 1959. Stuttgart: Thieme; 1959.

    Google Scholar 

  56. Luchino F. BCG vaccination. Am Rev Respir Dis. 1982;125:70–2.

    Google Scholar 

  57. Sakula A. Selman Waksman (1888–1973), discoverer of streptomycin: a centenary review. Br J Dis Chest. 1988;82:23–31.

    Article  CAS  PubMed  Google Scholar 

  58. Deroy MS, Fisher H. The treatment of tuberculous bone disease by surgical drainage combined with streptomycin. J Bone Joint Surg Am. 1952;34:299–330.

    Article  PubMed  Google Scholar 

  59. Hodgson AR, Stock FE. Anterior spinal fusion for the treatment of tuberculosis of the spine. J Bone Joint Surg Am. 1960;42:1147–56.

    Article  Google Scholar 

  60. Orell S. Chemotherapy and surgical treatment in bone and joint tuberculosis. Acta Orthop Scand. 1951;21:109–203.

    Google Scholar 

  61. Ostman P. Combined surgical and chemotherapy of abscesses in bone and joint tuberculosis. Acta Orthop Scand. 1951;21:204–10.

    Article  CAS  PubMed  Google Scholar 

  62. Hodgson AR, Stock FE, Fang HS, Ong GB. Anterior spinal fusion: the operative approach and pathological findings in 412 patients with Pott’s disease of the spine. Br J Surg. 1960;48:172–8.

    Article  CAS  PubMed  Google Scholar 

  63. Rajasekaran S. The problem of deformity in spinal tuberculosis. Clin Orthop Relat Res. 2002;398:85–92.

    Article  Google Scholar 

  64. Tuli SM. Results of treatment of spinal tuberculosis by middle path regime. J Bone Joint Surg Br. 1975;57:13–23.

    Article  CAS  PubMed  Google Scholar 

  65. Kondo E, Yamada K. End results of focal débridement in bone and joint tuberculosis and its indications. J Bone Joint Surg Am. 1957;39:27–31.

    Article  PubMed  Google Scholar 

  66. Wilkinson MC. Tuberculosis of the spine treated by chemotherapy and operative debridement: a long-term follow-up study. J Bone Joint Surg Am. 1969;51:1331–42.

    Article  CAS  PubMed  Google Scholar 

  67. Medical Research Council. A 10-year assessment of controlled trials comparing debridement and anterior spinal fusion in the management of tuberculosis of the spine in patients on standard chemotherapy in Hong Kong. Seventh report of the Medical Research Council Working Party on Tuberculosis of the Spine. J Bone Joint Surg Br. 1985;64:393–8.

    Google Scholar 

  68. A 15-year assessment of controlled trials of the management of tuberculosis of the spine in Korea and Hong Kong. Thirteenth report of the medical research council working party on tuberculosis of the spine. J Bone Joint Surg Br. 1998;80(3):456–62.

    Article  Google Scholar 

  69. A controlled trial of anterior spinal fusion and debridement in the surgical management of tuberculosis of the spine in patients on standard chemotherapy: a study in two centres in South Africa. Seventh report of the medical research council working party on tuberculosis of the spine. Tubercle. 1978;59(2):79–10544.

    Google Scholar 

  70. Rajasekaran S, Khandelwal G. Drug therapy in spinal tuberculosis. Eur Spine J. 2013;22(Suppl 4):587–93.

    Article  PubMed  Google Scholar 

  71. Oga M, Arizono T, Takasita M, Sugioka Y. Evaluation of the risk of instrumentation as a foreign body in spinal tuberculosis. Clinical and biologic study. Spine. 1993;18(13):1890–4.

    Article  CAS  PubMed  Google Scholar 

  72. Ha KY, Chung YG, Ryoo SJ. Adherence and biofilm formation of Staphylococcus epidermidis and Mycobacterium tuberculosis on various spinal implants. Spine (Phila Pa). 1976. 2005;30:38–43.

    Article  Google Scholar 

  73. Basu S, Chatterjee S, Bhattacharyya MK. Efficacy and safety of instrumentation in caries spine. Indian J Orthop. 2006;40:78–81.

    Article  Google Scholar 

  74. Chacko AG, Moorthy RK, Chandy MJ. The transpedicular approach in the management of thoracic spine tuberculosis: a short-term follow up study. Spine. 2005;29(17):E363–7.

    Article  Google Scholar 

  75. Sahoo MM, Mahapatra SK, Sethi GC, Dash SK. Posterior-only approach surgery for fixation and decompression of thoracolumbar spinal tuberculosis: a retrospective study. J Spinal Disord Tech. 2012;25(7):E217–23.

    Article  PubMed  Google Scholar 

  76. Zhang H, Sheng B, Tang M, Guo C, Liu S, Huang S, et al. One-stage surgical treatment for upper thoracic spinal tuberculosis by internal fixation, debridement, and combined interbody and posterior fusion via posterior-only approach. Eur Spine J. 2013;22(3):616–23.

    Article  PubMed  Google Scholar 

  77. Zaveri GR, Mehta SS. Surgical treatment of lumbar tuberculous spondylodiscitis by transforaminal lumbar interbody fusion (TLIF) and posterior instrumentation. J Spinal Disord Tech. 2009;22(4):257–62.

    Article  PubMed  Google Scholar 

  78. Rustomjee R, Diacon AH, Allen J, Venter A, Reddy C, Patientia RF, Mthiyane TC, De Marez T, van Heeswijk R, Kerstens R, et al. Early bactericidal activity and pharmacokinetics of the diarylquinoline TMC207 in treatment of pulmonary tuberculosis. Antimicrob Agents Chemother. 2008;52:2831–5.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  79. Matsumoto M, Hashizume H, Tomishige T, Kawasaki M, Tsubouchi H, Sasaki H, Shimokawa Y, Komatsu M. OPC-67683, a nitro-dihydroimidazooxazole derivative with promising action against tuberculosis in vitro and in mice. PLoS Med. 2006;3:e466.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  80. Gler MT, Skripconoka V, Sanchez-Garavito E, Xiao H, Cabrera-Rivero JL, Vargas-Vasquez DE, Gao M, Awad M, Park SK, Shim TS, et al. Delamanid for multidrug-resistant pulmonary tuberculosis. N Engl J Med. 2012;366:2151–60.

    Article  CAS  PubMed  Google Scholar 

  81. Ahmad Z, Peloquin CA, Singh RP, Derendorf H, Tyagi S, Ginsberg A, Grosset JH, Nuermberger EL. PA-824 exhibits time-dependent activity in a murine model of tuberculosis. Antimicrob Agents Chemother. 2011;55:239–45.

    Article  CAS  PubMed  Google Scholar 

  82. Diacon AH, Dawson R, Hanekom M, Narunsky K, Maritz SJ, Venter A, Donald PR, van Niekerk C, Whitney K, Rouse DJ, et al. Early bactericidal activity and pharmacokinetics of PA-824 in smear positive tuberculosis patients. Antimicrob Agents Chemother. 2010;54:3402–7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2022 The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Dagar, A., Sengupta, D.K. (2022). Historical Perspectives of Musculoskeletal Tuberculosis. In: Dhatt, S.S., Kumar, V. (eds) Tuberculosis of the Spine. Springer, Singapore. https://doi.org/10.1007/978-981-16-9495-0_1

Download citation

  • DOI: https://doi.org/10.1007/978-981-16-9495-0_1

  • Published:

  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-16-9494-3

  • Online ISBN: 978-981-16-9495-0

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics