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In Vitro Production of Coumarins

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Nutraceuticals Production from Plant Cell Factory

Abstract

Coumarin is a multitudinous nutraceutical compound naturally presented in various part of the plant and can be also produced by microorganisms. Additionally, coumarin can be produced at large-scale through in vitro plant cell culture systems. Coumarins can be found in simple, linear, and angular form, and the biosynthesis pathway of coumarins involves hydroxylation, glycolysis, and cyclization. The extraction process of coumarins requires using polar and nonpolar solvents, and the identification and quantification of coumarins can be performed by chromatographic techniques. Coumarins have attracted considerable attention in recent years due to their potential biological and pharmaceutical properties such as anticancer, anti-inflammatory, antimicrobial, antioxidant, and anticonvulsant properties. These medicinal properties of coumarin and its derivatives demonstrate their significance as promising nutraceutical for multifunctional applications. This chapter mainly discusses biosynthesis, in vitro production, different extractions, and detection methods of coumarins. In addition, the biological activities and the commercial applications of coumarins are also discussed.

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Abbreviations

bw:

Body weight

DAD :

Diode array detector

FTIR:

Fourier transform mid-infrared

GC-MS :

Chromatography-mass spectrometry

HPLC:

High-performance liquid chromatography

HPLC-MS/MS:

High-performance liquid chromatography-mass spectrometry

UHPLC:

Ultra-high-performance liquid chromatography

UHPLC-DAD:

Ultra-high-performance liquid chromatography-diode array detector

UV:

Ultraviolet

V:

Volt

W:

Watt

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Correspondence to Muneera Q. Al-Mssallem .

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© 2022 The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.

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Al-Mssallem, M.Q., Alissa, F.M. (2022). In Vitro Production of Coumarins. In: Belwal, T., Georgiev, M.I., Al-Khayri, J.M. (eds) Nutraceuticals Production from Plant Cell Factory. Springer, Singapore. https://doi.org/10.1007/978-981-16-8858-4_7

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