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Overview on Biological Activities of Thiazole Derivatives

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Nanostructured Biomaterials

Part of the book series: Materials Horizons: From Nature to Nanomaterials ((MHFNN))

Abstract

In the disciplines of pharmaceutical chemistry and drug discovery process, thiazole derivatives are one of the most prominent and widely used heterocycles. The distinctive structural features processed by thiazoles place them in the special category of molecules that are essential in biological and medicinal chemistry fields. The thiazole cores exhibit a broad extent of pharmacological and biological activities using weak interactions with receptors and enzymes in the biological system. In particular, several thiazole derivatives with immense therapeutic potency have been well explored as clinical drugs to treat different types of diseases. This chapter illustrates the current developments on thiazole derivatives as antitumour, antimicrobial, anti‐inflammatory, antiviral, anticancer and other medicinal agents to attain prominence in medicinal chemistry fields.

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Abbreviations

U.S. FDA:

United States Food and Drug Administration

WHO:

World Health Organization

LEDs:

light-emitting diode

DNA:

Deoxyribonucleic Acid

CNS:

Central Nervous System

PBP3:

penicillin-binding protein 3

NTZ:

Nitazoxanide

NSAID:

Non-steroidal Anti-inflammatory Drugs

PFOR:

Pyruvate: Ferredoxin/Flavodoxinoxidoreductase

OAB:

Overactive Bladder Symptoms

HER2:

Human Epidermal Growth Factor Receptor 2

RNA:

Ribonucleic Acid

HCV:

Hepatitis C Virus

COX:

Cyclooxygenase

CYP3A:

Cytochrome P450 3A

AD:

Alzheimer's Disease 

GERD:

Gastroesophageal Reflux Disease

PI3K-α:

Phosphotidylinositol-3-kinase-α

TPOR:

Thrombopoietin Receptor

PARP:

poly(ADP-ribose)polymerase

IMPDH:

Inosine-5′-monophosphate dehydrogenase

TNF-α:

Tumour necrosis factor alpha

XMP:

Xanthosine monophosphate

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Authors and Affiliations

  1. Department of Chemistry, National Institute of Technology Manipur, Langol, Imphal, Manipur, 795004, India

    Raghuram Gujjarappa, Arup K. Kabi, Nagaraju Vodnala, Ujjawal Tyagi, Dhananjaya Kaldhi & Chandi C. Malakar

  2. Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), Kolkata, Chunilal Bhawan 168, Maniktala Main Road, Kolkata, 700054, India

    Sattu Sravani, Aakriti Garg & Sreya Gupta

Authors
  1. Raghuram Gujjarappa
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  2. Arup K. Kabi
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  4. Aakriti Garg
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  5. Nagaraju Vodnala
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  6. Ujjawal Tyagi
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  9. Chandi C. Malakar
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Correspondence to Chandi C. Malakar .

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  1. Department of Physics, National Institute of Technology Manipur, Imphal, India

    Bibhu Prasad Swain

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Gujjarappa, R. et al. (2022). Overview on Biological Activities of Thiazole Derivatives. In: Swain, B.P. (eds) Nanostructured Biomaterials. Materials Horizons: From Nature to Nanomaterials. Springer, Singapore. https://doi.org/10.1007/978-981-16-8399-2_5

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