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Micro- and Nano-containers for Smart Applications pp 327–357Cite as

CDs: A Potential Candidate for Improving Water Solubility and Stability of Hydrophobic Guest Molecules

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Part of the Composites Science and Technology book series (CST)

Abstract

CDs and their derivatives have been used in various industries due to their specific capability to form inclusion complexes via reversible interactions with hydropho and hydrophil chemical structures. This characteristic of CDs has caused their applications in solubility control (change the solubility), stabilization of volatile compounds, masking unpleasant smells of the guest, enhancing the complexation efficiency, reduction of volatility, directing chemical reactions, controlling Fluorescence and light absorption, compatibility with other materials, encapsulation of wide ranges of guest molecules and changing their properties and also controlled release of guest molecules in drug delivery systems. In pharmaceutical industry, improving water solubility and bioavailability of drugs are highly important and can act as a challenge in controlled drug delivery. Encapsulation bring out specific alteration in properties of the guest molecules such as increase shelf time, stabilization of light-sensitive molecules, oxygen-sensitive and highly volatile components, change chemical and physical properties of guest molecules, increasing solubility of guest molecules with low solubility, protection of substances against degradation by microorganisms, UV light, oxidation and chemical reactions and masking unpleasant smells or tastes, pigments or the color of guest molecules. In this review, application of CDs inclusion complex formation for improving water solubility and controlled release of some hydrophobic guests (ibuprofen, acetaminophen, curcumin, cinnamon essential oil, ciprofloxacin and ofloxacin) were explained.

Keywords

  • CD
  • Inclusion complex formation
  • Ciprofloxacin
  • Ibuprofen
  • Curcumin
  • Cinnamon essential oil
  • Ofloxacin
  • Acetaminophen
  • Phase solubility

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Author information

Authors and Affiliations

  1. Department of Polymer Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran

    Sahar Amiri

  2. Department of Polymer Engineering, Amirkabir University of Tehran, Tehran, Iran

    Sanam Amiri

Authors
  1. Sahar Amiri
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  2. Sanam Amiri
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Corresponding author

Correspondence to Sahar Amiri .

Editor information

Editors and Affiliations

  1. Department of Science, Alliance University, Faculty of Science & Technology, Bengaluru, Karnataka, India

    Dr. Jyotishkumar Parameswaranpillai

  2. Swinburne University of Technology, Hawthorn, VIC, Australia

    Dr. Nisa V. Salim

  3. King Mongkut's University of Technology, Bangkok, Thailand

    Dr. Harikrishnan Pulikkalparambil

  4. King Mongkut's University of Technology, Bangkok, Thailand

    Dr. Sanjay Mavinkere Rangappa

  5. King Mongkut's University of Technology, Bangkok, Thailand

    Prof. Dr. Ing. habil Suchart Siengchin

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Amiri, S., Amiri, S. (2022). CDs: A Potential Candidate for Improving Water Solubility and Stability of Hydrophobic Guest Molecules. In: Parameswaranpillai, J., V. Salim, N., Pulikkalparambil, H., Mavinkere Rangappa, S., Suchart Siengchin, I.h. (eds) Micro- and Nano-containers for Smart Applications. Composites Science and Technology . Springer, Singapore. https://doi.org/10.1007/978-981-16-8146-2_15

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