Abstract
The traditional Indian medicine like Ayurveda and Siddha and traditional Chinese medicine remain the most ancient therapies. While Ayurveda originated in North and is popular in entire India and world, Siddha system of medicine is majorly practiced in South of India. Similarly, Chinese system of medicine is also evolved and established in thousands of years. There is an important aspect of maintaining wellness from these traditional systems which includes the concept of development of inherent immunity to sustain better health throughout the life. There has been increased surge of global interest in traditional medicines’ probable prophylactic/therapeutic measure for the modulation of immune response. Herbs have shown potential of being used as immunomodulators especially the drugs used in alternative system of medicine have been documented to possess immunomodulatory properties. Modulation of immune response to mitigate the diseases was the approach of Rasayana in Ayurveda is based on interrelated principles. Rasayana drugs in Ayurveda are known to increase longevity, stop aging, and offer resistance to disease by increasing the immune system. Many plants like Terminalia arjuna, Glycyrrhiza glabra, Withania somnifera, Swertia chirayita, Nardostachys jatamansi, Picrorhiza sps., Chlorophytum borivilianum, Asparagus racemosus, etc. used in Ayurvedic system of medicine for Rasayana therapy have been investigated for their therapeutic effects on the immune system. There have been constant efforts to screen and standardize herbal drugs and traditional medicines from Ayurvedic and Himalayan plants. Traditional system of medicine still necessitates more extensive evidence-based scientific research. This chapter gives an overview of basic principles and cohesions of different traditional medicine system and key elements of these great plant-based traditions need to address to compete in global market. Further it incorporates an extensive data on plants used under these traditional systems as well the mechanism involved in the pharmacological findings with a view to appreciate immunomodulation properties of phytomolecules from these plants.
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References
Abdul KM, Ramchender RP (1995) Modulatory effect of plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone) on macrophage funct. Immunopharmacology 30:231–236
Abeysekera AM, De Silva KTD, Samarasinghe S, Seneviratne PAK, Van Den Berg AJJ, Labadie RP (1996) An immunomodulatory C-glucosylated propelargonidin from the unripe fruit of Aegle marmelos. Fitoterapia 67:367–370
Abu-Rizq HA, Mansour MH, Safer AM, Afzal M (2008) Cyto-protective and immunomodulating effect of Curcuma longa in Wistar rats subjected to carbon tetrachloride-induced oxidative stress. Inflammopharmacology 16:87–95
Afolayan FID, Erinwusi B, Oyeyemi OT (2018) Immunomodulatory activity of curcumin-entrapped poly d,l-lactic-co-glycolic acid nanoparticles in mice. Integr Med Res 7(2):168–175
Ahmad S, Mika D, Guruvayoorappan C (2012) Chemoprotective and immunomodulatory effect of Acacia nilotica during cyclophosphamide induced toxicity. J Exp Ther Oncol 10(2):83–90
Akram M, Hamid A, Khaliu A, Ghaffar A, Tayyaba N, Saeed A, Alf M, Naveed A (2014) Review on medicinal uses, pharmacological, phytochemistry and immunomodulatory activity of plants. Int J Immunopathol Pharmacol 27(3):313–319
Alexyuk PG, Bogoyavlenskiy AP, Alexyuk MS, Turmagambetova AS, Zaitseva IA, Omirtaeva ES, Berezin VE (2009) Adjuvant activity of multimolecular complexes based on Glycyrrhiza glabra saponins, lipids, and influenza virus glycoproteins
Anjum V, Arora P, Ansari SH, Najmi AK, Ahmad S (2017) Antithrombocytopenic and immunomodulatory potential of metabolically characterized aqueous extract of Carica papaya leaves. Pharm Biol 55(1):2043–2056. https://doi.org/10.1080/13880209.2017.1346690. PMID: 28836477; PMCID: PMC6130488
Ashok BT, Ali R (2003) Aging research in India. Exp Gerontol 38:597–603
Asteriou E, Gkoutzourelas A, Mavropoulos A, Katsiari C, Sakkas LI, Bogdanos DP (2018) Curcumin for the management of periodontitis and early ACPA-positive rheumatoid arthritis: killing two birds with one stone. Nutrients 10(7):908
Azad R, Babu NK, Gupta AD, Reddanna P (2018 Nov) Evaluation of anti-inflammatory and immunomodulatory effects of Premna integrifolia extracts and assay-guided isolation of a COX-2/5-LOX dual inhibitor. Fitoterapia 131:189–199. https://doi.org/10.1016/j.fitote.2018.10.016
Bafna AR, Mishra SH (2004) Immunomodulatory activity of methanol extract of flower-heads of Sphaeranthus indicus Linn. Ars Pharmac 45:281–291
Bafna AR, Mishra SH (2005) Immunomodulatory activity of methanol extract of roots of Cissampelos pareira Linn. Ars Pharm 46(3):253–262
Bhat BA, Dhar KL, Puri SC, Qurishi MA, Khajuria A, Gupta A, Qaz GN (2005) Isolation, characterization and biological evaluation of Datura lactones as potential immunomodulators. Bioorg Med Chem 13:6672–6677
Bhattacharjee S, Bhattacharjee A, Majumder S, Majumdar SB, Majumdar S (2012) Glycyrrhizic acid suppresses Cox-2-mediated anti-inflammatory responses during Leishmania donovani infection. J Antimicrob Chemother 67(8):1905–1914. https://doi.org/10.1093/jac/dks159. Epub 2012 May 15
Calabrese C, Berman SH, Babish JG et al (2000) A phase I trial of andrographolide in HIV positive patients and normal volunteers. Phytother Res 14(5):333–338
Chakraborty K, Bose A, Pal S, Sarkar K, Goswami S, Ghosh D, Laskar S, Chattopadhyay U, Baral R (2008) Neem leaf glycoprotein restores the impaired chemotactic activity of peripheral blood mononuclear cells from head and neck squamous cell carcinoma patients by maintaining CXCR3/CXCL10 balance. Int Immunopharmacol 8:330–340
Chattopadhyay SK, Pal A, Maulik PR, Kaur T, Garga A, Khanuja SPS (2006) Taxoid from the needles of the Himalayan yew Taxus wallichiana with cytotoxic and immunomodulatory activities. Bioorg Med Chem Lett 16:2446–2449
Chaturvedi VS (2008) Fit for life through ayurveda. Sterling Publishers Pvt. Ltd., New Delhi
Chauhan NS, Saraf DK, Dixit VK (2010) Effect of vajikaran rasayana herbs on pituitary-gonadal axis. Eur J Integr Med 2(2):89–91
Chavali SR, Francis T, Campbell JB (1987) An in vitro study of immunomodulatory effects of some saponins. Int J Immunopharmacol 9(6):675–683. https://doi.org/10.1016/0192-0561(87)90038-5
Chakrabortty S, Choudhary R (2014) Hemidesmus indicus (anantmool): rare herb of Chhattisgarh. Indian J Sci Res 4(1):89–93
Cheel J, Van Antwerpen P, Tůmová L, Onofre G, Vokurková D, Zouaoui-Boudjeltia K, Vanhaeverbeek M, Nève J (2010) Free radical-scavenging antioxidant and immunostimulating effects of a licorice infusion (Glycyrrhiza glabra L.). Food Chem 122(3):508–517. https://doi.org/10.1016/j.foodchem.2010.02.060
Cherng JM, Chiang W, Chian LC (2007) Immunomodulatory activities of common vegetables and spices of Umbelliferae and its related coumarins and flavonoids. Food Chem. https://doi.org/10.1016/j.foodchem.2007.07.005
Damre AS, Gokhale AB, Phadke AS, Kulkarni KR, Saraf MN (2003) Studies on the immunomodulatory activity of flavonoidal fraction of Tephrosia purpurea. Fitoterapia 74:257–261
Dangar K, Varsani V, Vyas S (2021) To review on Indian spices and herbs has a promising activity to boosting immunity against deadly coronavirus infection. Int J Bot Stud 6(1):89–91
Das K (2021) Herbal plants as immunity modulators against COVID-19: A primary preventive measure during home quarantine. J Herb Med 100501
Das A, Jawed JJ, Das MC, Sandhu P, De UC, Dinda B, Akhter Y, Bhattacharjee S (2017) Antileishmanial and immunomodulatory activities of lupeol, a triterpene compound isolated from Sterculia villosa. Int J Antimicrob Agents 50(4):512–522. https://doi.org/10.1016/j.ijantimicag.2017.04.022. Epub 2017 Jun 29
Dash S, Nath LK, Bhise S, Kar P, Bhattacharya S (2006) Stimulation of immune function activity by the alcoholic root extract of Heracleum nepalense D. Don. Indian J Pharmacol 38:336–340
Datta S, Sinha S, Bhattacharyya P (1999) Effect of a herbal protein, CI-1, isolated from Cajanus indicus on immune response of control and stressed mice. J Ethnopharmacol 67:259–267
Dhyani A, Nautiyal BP, Nautiyal MC (2010) Importance of Astavarga plants in traditional systems of medicine in Garhwal, Indian Himalaya. Int J Biodivers Sci Ecosyst Serv Manag 6(1-2):13–19
Ding Y, Chen L, Wu W, Yang J, Yang Z (2017) Liu S Andrographolide inhibits influenza A virus-induced inflammation in a murine model through NF-κB and JAK-STAT signaling pathway. Microbes Infect 19(12):605–615
Elabd H, Wang HP, Shaheen A, Yao H, Abbass A (2016) Feeding Glycyrrhiza glabra (liquorice) and Astragalus membranaceus (AM) alters innate immune and physiological responses in yellow perch (Perca flavescens). Fish Shellfish Immunol 54:374–384. https://doi.org/10.1016/j.fsi.2016.04.024
Ehteshamfar SM, Akhbari M, Afshari JT et al (2020) Anti-inflammatory and immune-modulatory impacts of berberine on activation of autoreactive T cells in autoimmune inflammation. J Cell Mol Med 24(23):13573–13588. https://doi.org/10.1111/jcmm.16049
Escribano J, Daz-Guerra MJM, Riese HH, Ontanon J, Garca-Olmo D, Garca-Olmo DC, Rubio A, Fernandez JA (1999) In vitro activation of macrophages by a novel proteoglycan isolated from corms of Crocus sativus L. Cancer Lett 144:107–114
Gabhe SY, Tatke PA, Khan TA (2006) Evaluation of the immunomodulatory activity of the methanol extracts of Ficus benghalensis roots in rats. Indian J Pharmacol 38:271–275
Gautam M, Diwanay S, Gairola S, Shinde Y, Patki P, Patwardhan B (2004) Immunoadjuvant potential of Asparagus racemosus aqueous extract in experimental system. J Ethnopharmacol 91:251–255
Gayathri V, Asha VV, Subramoniam A (2005) Preliminary studies on the immunomodulatory and antioxidant properties of Selaginella species. Indian J Pharmacol 37:381–385
Geetha S, Sai Ram M, Singh V, Ilavazhagan G, Sawhney RC (2002) Anti-oxidant and immunomodulatory properties of sea buckthorn (Hippophae rhamnoides)—an in vitro study. J Ethnopharmacol 79:373–378
Ghafoor F (2020) Importance of herbs in aquaculture; Cinnamon a potent enhancer of growth and immunity in fish, Ctenopharyngodon idella. Iran J Aquat Anim Health 6(1):78–92
Ghazanfaria T, Hassanb ZM, Ebrahimi M (2002) Immunomodulatory activity of a protein isolated from garlic extract on delayed type hypersensitivity. Int Immunopharmacol 2:1541–1549
Ghosal S, Lal SJ, Srivastava R, Bhattacharya SK, Upadhyay SN, Jaiswal AK, Chattopadhyay U (1989) Immunomodulatory and CNS Effects of Sitoindosides IX and X, Two New Glycowithanolides from Withania somnifera. Phytother Res 3:201–206
Ghule BV, Murugananthan G, Nakhat PD, Yeole PG (2006) Immunostimulant effects of Capparis zeylanica Linn. Leaves. J Ethnopharmacol 24:311–315
Gokhale AB, Damre AS, Saraf MN (2003) Investigation into the immunomodulatory activity of Argyreia speciosa. J Ethnopharmacol 84:109–114
Gracious Ross R, Selvasubramanian S, Jayasundar S (2001) Immunomodulatory activity of Punica granatum in rabbits—a preliminary study. J Ethnopharmacol 78:85–87
Gupta A, Chaphalkar SR (2017) Assessment of immunomodulatory activity of aqueous extract of Calamus rotang. Avicenna J Phytomed 7(3):199–205. PMID: 28748166; PMCID: PMC5511971
Gupta S, Mishra KP, Dash PK, Parida M, Ganju L, Singh SB (2018) Andrographolide inhibits chikungunya virus infection by up-regulating host innate immune pathways. Asian Pac J Trop Med 11(3):214–221
Guruvayoorappan C, Kuttan G (2007) Immunomodulatory and antitumor activity of Biophytum sensitivum extract. Asian Pac J Cancer Prev 8:27–32
Hafeez BB, Haque R, Parvez S, Pandey S, Sayeed I, Raisuddin S (2003) Immunomodulatory effects of fenugreek (Trigonella foenum graecum L.) extract in mice. Int Immunopharmacol 3:257–265
Hamsa TP, Kuttan G (2010) Ipomoea obscura ameliorates cyclophosphamide-induced toxicity by modulating the immune system and levels of proinflammatory cytokine and GSH. Can J Physiol Pharmacol 88(11):1042–1053. https://doi.org/10.1139/y10-086
Harlev E, Nevo E, Lansky EP, Ofir R, Bishayee A (2012) Anticancer potential of aloes: antioxidant, antiproliferative, and immunostimulatory attributes. Planta Med 78(9):843–852
Huang CT, Hung CY, Hseih YC, Chang CS, Velu AB, He YC, Huang YL, Chen TA, Chen TC, Lin CY, Lin YC, Shih SR, Dutta A (2019 Nov) Effect of aloin on viral neuraminidase and hemagglutinin-specific T cell immunity in acute influenza. Phytomedicine 64:152904
Jantan I, Ahmad W, Bukhari SNA (2015) Plant-derived immunomodulators: an insight on their preclinical evaluation and clinical trials. Front Plant Sci 6:655
Jayaprakash B, Das A (2018) Extraction and characterization of chick PEA (Cicer arietinum) extract with immunostimulant activity in BALB/C MICE. Asian Pac J Cancer Prev 19(3):803–810. https://doi.org/10.22034/APJCP.2018.19.3.803. PMID: 29582638; PMCID: PMC5980859
Jayathirtha MG, Mishra SH (2004) Preliminary immunomodulatory activities of methanol extracts of Eclipta alba and Centella asiatica. Phytomedicine 11:361–365
Jee BS (1927) A short history of aryan medical science, 2nd edn. Shree Bhabyat Singh Jee Electric Printing Press, Gondal
Joharapurkar AA, Deode NM, Zambad SP, Umathe SN (2003) Immunomodulatory activity of alcoholic extract of Rubia cordifolia Linn. Indian Drugs 40:179–181
Joshi UP, Mishra SH (2008) Evaluation of aqueous and methanol extracts of Pistacia integerrima galls as potential immunomodulator. Pharmacogn Mag 4:126–131
Kaul A, Bani S, Zutshi U, Suri KA, Satti NK, Suri OP (2003) Immunopotentiating properties of cryptolepis buchanani root extract. Phytother Res 17:1140–1144
Ketha K, Gudipati M (2018 Nov) Immunomodulatory activity of non starch polysaccharides isolated from green gram (Vigna radiata). Food Res Int 113:269–276. https://doi.org/10.1016/j.foodres.2018.07.010
Khajuria A, Gupta A, Garaib S, Wakhloo BP (2007) Immunomodulatory effects of two sapogenins 1 and 2 isolated from Luffa cylindrica in Balb/C mice. Bioorg Med Chem Lett 17:1608–1612
Khajuria A, Gupta A, Suden P, Singh S, Malik F, Singh J, Gupta BD, Suri KA, Srinivas VK, Ella K, Qazi GN (2008) Immunomodulatory activity of biopolymeric fraction BOS 2000 from Boswellia serrata. Phytother Res 22:340–348
Kokate CK, Purohit AP, Gokhale SB (2010) Pharmacognosy. Publisher Nirali Prakashan, New Delhi
Kroes BH, Beukelman CJ, van den Berg AJ, Wolbink GJ, van Dijk H, Labadie RP (1997) Inhibition of human complement by beta-glycyrrhetinic acid. Immunology 90(1):115–120. https://doi.org/10.1046/j.1365-2567.1997.00131.x. PMID: 9038721; PMCID: PMC1456728
Kubo M, Namba K, Nagamoto N, Nagao T, Nakanishi J, Uno H, Nishimura H (1983) A new phenolic glucoside, curculigoside from rhizomes of Curculigo orchioides. Planta Med 47:52–55
Kulkarni SR, Karande VS (1998) Study of the immunostimulant activity of Naphthoquinone extract of leaves of Lawsonia alba Linn. Indian Drugs:427–433
Kumar KS, Bhowmik D, Dutta A, Yadav AP, Paswan S, Srivastava S, Deb L (2012) Recent trends in potential traditional Indian herbs Emblica officinalis and its medicinal importance. J Pharmacogn Phytochem 1(1):18–28
Kumar RA, Sridevi K, Kumar NV, Nanduri S, Rajagopal S (2004) Anticancer and immunostimulatory compounds from Andrographis paniculata. J Ethnopharmacol 92(2–3):291–295
Kumari R, Kumar S, Kumar A, Goel KK, Dubey RC (2017) Antibacterial, antioxidant and Immuno-modulatory properties in extracts of Barleria lupulina Lindl. BMC Complement Altern Med 17(1):484. https://doi.org/10.1186/s12906-017-1989-4. PMID: 29100518; PMCID: PMC5670697
Lad VS (2002) Fundamental Principles of Ayurveda. The Ayurvedic Press, Albuquerque, New Mexico
Lakshmi V, Pandey K, Puri A, Saxena RP, Saxena KC (2003) Immunostimulant principles from Curculigo orchioides. J Ethnopharmacol 89:181–184
Latha PG, Evans DA, Panikar KR, Jayavardhan KK (2000) Immunomodulatory and antitumour properties of Psoralea corylifolia seeds. Fitoterapia 71:223–231
Lee SY, Ryu IW, Shim CS (1997) Purification and characterization of bioactivity compound acemannan from Aloe vera. Korean J Pharmac 28:65–71
Lee JH, Lee JY, Park JH, Jung S, Kim JS, Kang SS, Kim YS, Han Y (2007) Immunoregulatory activity by daucosterol, a sitosterol glycoside, induces protective Th1 immune response against disseminated Candidiasis in mice. Vaccine 25:3834–3840
Lee G, Chung HS, Lee K, Lee H, Kim M, Bae H (2017 Sep) Curcumin attenuates the scurfy-induced immune disorder, a model of IPEX syndrome, with inhibiting Th1/Th2/Th17 responses in mice. Phytomedicine 15(33):1–6
Lee W, Yang S, Lee C, Park EK, Kim KM, Ku SK, Bae JS (2019) Aloin reduces inflammatory gene iNOS via inhibition activity and p-STAT-1 and NF-κB. Food Chem Toxicol 126:67–71. https://doi.org/10.1016/j.fct.2019.02.025. Epub 2019 Feb 13
Lei J, Shen Y, Xv G, Di Z, Li Y, Li G (2020) Aloin suppresses lipopolysaccharide-induced acute lung injury by inhibiting NLRP3/NF-κB via activation of SIRT1 in mice. Immunopharmacol Immunotoxicol 42(4):306–313
Logambal SM, Venkatalakshmi S, Dinakaran Michael RD (2000) Immunostimulatory effect of leaf extract of Ocimum sanctum Linn in Oreochromis mossambicus (Peters). Hydrobiologia 430:113–120
Madakkannu B, Ravichandran R (2017) In vivo immunoprotective role of Indigofera tinctoria and Scoparia dulcis aqueous extracts against chronic noise stress induced immune abnormalities in Wistar albino rats. Toxicol Rep 6(4):484–493. https://doi.org/10.1016/j.toxrep.2017.09.001. PMID: 28959678; PMCID: PMC5615165
Makare N, Bodhankar S, Rangari V (2001) Immunomodulatory activity of alcoholic extract of Mangifera indica L in Mice. J Ethnopharmacol 78:133–137
Malik F, Singh J, Khajuria A, Suri KA, Satti NK, Singh S, Kaul MK, Kumar A, Bhatia A, Qazi GH (2007) A standardized root extract of Withania somnifera and its major constituent withanolide-A elicit humoral and cell-mediated immune responses by up regulation of Th1-dominant polarization in BALB/c mice. Life Sci 80:1525–1538
Manjrekar PN, Jolly CI, Narayanan S (2000) Comparative studies of the immunomodulatory activity of Tinospora cordifolia and Tinospora sinensis. Fitoterapia 71:254–257
Manjula N, Gayathri B, Vinaykumar KS, Shankernarayanan NP, Vishwakarmab RA, Balakrishnan A (2006) Inhibition of MAP kinases by crude extract and pure compound isolated from Commiphora mukul leads to down regulation of TNF-a, IL-1h and IL-2. Int Immunopharmacol 6:122–132
Manjulatha K, Saritha K, Setty OH (2014) Phytochemistry, Pharmacology and Therapeutics of Hemidesmus indicus (L.) R. Br
Mashhadi NS, Ghiasvand R, Askari G, Hariri M, Darvishi L, Mofid MR (2013) Anti-oxidative and anti-inflammatory effects of ginger in health and physical activity: review of current evidence. Int J Prev Med 4(Suppl 1):S36
Maurya S, Sangwan NS (2019) Profiling of essential oil constituents in Ocimum species. Proc Ind Natl Acad Sci India Sect B Biol Sci 90(3):577–583. https://doi.org/10.1007/s40011-019-01123-8
Maurya R, Wazir V, Kapil A, Kapil S (1996) Cordifolioside A and B two new phenylpropene disaccharides from Tinospora cordifolia possessing immunostimulating activity. Nat Prod Lett 8:7–10
Mehrotra S, Mishra KP, Maurya R, Srimal RC, Singh VK (2002) Immunomodulation by ethanolic extract of Boerhaavia diffusa roots. Int Immunopharmacol 2:987–996
Melchior J, Spasov AA, Ostrovskij OV (2000) Double blind placebo controlled pilot and phase III study of activity of standardized Andrographis paniculata Herba Nees extract fixed combination (Kan jang) in the treatment of uncomplicated upper respiratory tract infection. Phytomedicine 7:341–350
Mishra PK, Singh N, Ahmad G, Dubeb A, Maurya R (2005) Glycolipids and other constituents from Desmodium gangeticum with antileishmanial and immunomodulatory activities. Bioorg Med Chem Lett 15:4543–4546
Misra L, Mishra P, Pandey A, Sangwan RS, Sangwan Neelam S, Tuli R (2008) Withanolides from Withania somnifera roots. Phytochem 69:1000–1005
Mishra SK, Sangwan NS, Sangwan RS (2007) Andrographis paniculata (Kalmegh): a review. Pharmacogn Rev 1(2):283–298
Michaelis M, Geiler J, Naczk P, Sithisarn P, Ogbomo H, Altenbrandt B, Leutz A, Doerr HW, Cinatl J Jr (2010) Glycyrrhizin inhibits highly pathogenic H5N1 influenza A virus-induced pro-inflammatory cytokine and chemokine expression in human macrophages. Med Microbiol Immunol 199(4):291–297. https://doi.org/10.1007/s00430-010-0155-0. Epub 2010 Apr 13. PMID: 20386921; PMCID: PMC7087222
Mojica-Henshaw M, Francisco AD, Guzman FD, Tigno XT (2003) Possible immunomodulatory actions of Carica papaya seed extract. J Clin Hemorheol Microcirc 29:219–229
Mahfuz S, Piao XS (2019) Application of Moringa (Moringa oleifera) as Natural Feed Supplement in Poultry Diets. Animals. 9(7):431. https://doi.org/10.3390/ani9070431
Mollazadeh H, Cicero AFG, Blesso CN, Pirro M, Majeed M, Sahebkar A (2017) Immune modulation by curcumin: the role of interleukin-10. Crit Rev Food Sci Nutr. 11:1–13. https://doi.org/10.1080/10408398.2017.1358139
Mungantiwar AA, Nair AM, Shinde UA, Dikshit VJ, Saraf VS, Thakur VS (1999) Studies on the immunomodulatory effects of Boerhaavia diffusa alkaloid fraction. J Ethnopharmacol 65:125–131
Naik RG, Kattige SL, Bhat SV, Alreja B, Desouza NJ, Rupp RH (1988) An inflammatory piperidyriylbenzopyranone from Dysoxylum binectariferum. Tetrahedron 44:2081–2086
Nair PK, Melnick SJ, Ramachandran R, Escalon E, Ramachandran C (2006) Mechanism of macrophage activation by (1,4)-alpha-D-glucan isolated from Tinospora cordifolia. Int Immunopharmacol 6:1815–1824
Narnoliya LK, Sangwan NS, Misra L et al (2021) Processes of high-yield isolation and flash chromatographic purification of azadiradione from neem fruits. Proc Natl Acad Sci, India Sect B Biol Sci 91(4):847–853. https://doi.org/10.1007/s40011-021-01254-x
Nandy S, Mukherjee A, Pandey DK, Ray P, Dey A (2020) Indian Sarsaparilla (Hemidesmus indicus): Recent progress in research on ethnobotany, phytochemistry and pharmacology. J Ethnopharmacol 254:112609
Nevin KG, Vijayammal PL (2005) Pharmacological and immunomodulatory effects of Aerva Lanata in Daltons lymphoma ascites-bearing mice. Pharm Biol 43:640–646
Otsuki N, Dang NH, Kumagai E, Kondo A, Iwata S, Morimoto C (2010) Aqueous extract of Carica papaya leaves exhibits anti-tumor activity and immunomodulatory effects. J Ethnopharmacol 127(3):760–767. https://doi.org/10.1016/j.jep.2009.11.024. Epub 2009 Dec 2
Pathak P, Shukla P, Kanshana JS, Jagavelu K, Sangwan NS, Dwivedi AK, Dikshit M (2021) Standardized root extract of Withania somnifera and Withanolide A exert moderate vasorelaxant effect in the rat aortic rings by enhancing nitric oxide generation. J Ethnopharmacol 278:114296. https://doi.org/10.1016/j.jep.2021.114296
Pandima DK, Sai Ram M, Sreepriya M, Ilavazhagan G, Devaki T (2003) Immunomodulatory effects of Premna tomentosa extract against Cr (VI) induced toxicity in splenic lymphocytes-an in vitro study. Biomed Pharmacother 57:105–108
Pandima DK, Sai Ram M, Sreepriya M, Devaki T, Ilavazhagan G, Selvamurthy W (2004) Immunomodulatory effects of Premna tomentosa (L. Verbenaceae) extract in J 779 macrophage cell cultures under chromate (VI)-induced immunosuppression. J Altern Complement Med 10:535–539
Park MY, Kwon HJ, Sung MK (2009) Evaluation of aloin and aloe-emodin as anti-inflammatory agents in aloe by using murine macrophages. Biosci Biotechnol Biochem 73(4):828–832
Patil JS, Nagavi BG, Ramesh M, Vijayakumar GS (1998) A study on the Immunostimulant activity of Centella asiatica in rats. Indian Drugs 38:711–714
Patwardhan B (2005) Botanical immunodrugs: scope and opportunities. Drug Discov Today 10:495–502
Peng GY, Zhou F, Ding RL, Li HD, Yao K (2002) Modulation of lianbizi injection (Andrographolide) on some immune functions. China J Chin Materia Medica 27(2):147–150
Prabhu V, Guruvayoorappan C (2012) Evaluation of immunostimulant activity and chemoprotective effect of mangrove Rhizophora apiculata against cyclophosphamide induced toxicity in Balb/c mice. Immunopharmacol Immunotoxicol 34:608–615
Pravansha S, Thippeswamy BS, Veerapur VP (2012 Dec) Immunomodulatory and antioxidant effect of Leptadenia reticulata leaf extract in rodents: possible modulation of cell and humoral immune response. Immunopharmacol Immunotoxicol 34(6):1010–1019
Pugh N, Ross SA, ElSohly MA, Pasco DSJ (2001) Characterization of Aloeride, a new high-molecular-weight polysaccharide from Aloe vera with potent immunostimulatory activity. J Agric Food Chem 49:1030–1034
Puri A, Sahai R, Singh KL, Saxena RP, Tandon JS, Saxena KC (2000) Immunostimulant activity of dry fruits and plant materials used in Indian traditional medical system for mothers after child birth and invalids. J Ethnopharmacol 71:89–92
Puri A, Saxena R, Saxena RP, Saxena KC (1993) Immunostimulant agents from Andrographis paniculata. J Nat Prod 56(7):995–999
Puri A, Saxena RP, Guru PY, Kulshreshtha DK, Saxena KC, Dhawan BN (1992) Immunostimulant activity of Picroliv, the iridoid glycoside fraction of Picrorhiza kurrooa, and its protective action against Leishmania donovani infection in hamsters. Planta Med 58:528–532
Puri A, Saxena R, Saxena RP, Saxena KC, Srivastava V, Tando JS (1994) Immunostimulant activity of Nyctanthes arbor tristis. J Ethnopharmacol 42:31–37
Puri HS (2002) Rasayana: ayurvedic herbs for longevity and rejuvenation. CRC Press, New Delhi
Qin LH, Kong L, Shi GJ, Wang ZT, Ge BX (2006) Andrographolide inhibits the production of TNF-alpha and interleukin-12 in lipopolysaccharide-stimulated macrophages: role of mitogen-activated protein kinases. Biol Pharm Bull 29(2):220–224
Raju N, Sakthivel KM, Kannan N, Vinod Prabhu V, Guruvayoorappan C (2015) Cuscuta chinensis ameliorates immunosuppression and urotoxic effect of cyclophosphamide by regulating cytokines - GM-CSF and TNF-alpha. Appl Biochem Biotechnol 176(3):742–757. https://doi.org/10.1007/s12010-015-1608-0
Ramprasath V, Shanthi P, Sachdanandam P (2006) Immunomodulatory and Anti-inflammatory Effects of Semecarpus anacardium Linn. Nut Milk Extract in Experimental Inflammatory Conditions. Biol Pharm Bull 29:693–700
Raphael TJ, Kuttan G (2003) Effect of naturally occurring triterpenoids glycyrrhizic acid, ursolic acid, oleanolic acid and nomilin on the immune system. Phytomedicine 10(6–7):483–489. https://doi.org/10.1078/094471103322331421
Routh HB, Bhowmik KR (1999) Traditional Indian medicine in dermatology. Clin Dermatol 17:41–47
Roy Deb S, Dash S, Dasgupta RK, Chakraborty J (2019) Modulatory potential on immune system of a new alkaloid isolated from Coccinea cordifolia root. Int J Biol Macromol 121:643–649. https://doi.org/10.1016/j.ijbiomac.2018.10.104
Sai Ram M, Neetu D, Yogesh B, Anju B, Dipti P, Pauline T, Sharma SK, Sarada SKS, Ilavazhagan G, Kumar D, Selvamurthy W (2002) Cyto-protective and immunomodulating properties of Amla (Emblica officinalis) on lymphocytes: an in-vitro study. J Ethnopharmacol 81:5–10
Sakthivel KM, Guruvayoorappan C (2015) Acacia ferruginea inhibits cyclophosphamide-induced immunosuppression and urotoxicity by modulating cytokines in mice. J Immunotoxicol 12(2):154–163. https://doi.org/10.3109/1547691X.2014.914988
Saravanan S, Pandikumar P, Prakash Babu N, Hairul Islam VI, Thirugnanasambantham K, Gabriel Paulraj M, Balakrishna K, Ignacimuthu S (2014) In vivo and in vitro immunomodulatory potential of swertiamarin isolated from Enicostema axillare (Lam.) A. Raynal that acts as an anti-inflammatory agent. Inflammation 37(5):1374–1388
Sangwan NS, Sangwan RS (2014) In: Opatrný Z, Nick P (eds) Secondary metabolites of traditional medical plants – case study Ashwaganda in applied cell technology in plant cell monographs. Springer, Germany, pp 325–367. ISBN 978-3-642-41786-3
Sangwan NS, Tripathi S, Srivastava Y, Mishra B, Pandey N (2017) Phytochemical genomics of ashwagandha. In: Kaul A, Wadhwa R (eds) Science of ashwagandha: preventive and therapeutic potentials. Springer, Cham, pp 3–36
Sehar I, Kaul A, Bani S, Pal HC, Saxena AK (2008) Immune up regulatory response of a non-caloric natural sweetener, stevioside. Chem Biol Interact 28:115–121
Singh SK, Valicherla GR, Bikkasani AK, Cheruvu SH, Hossain Z, Taneja I, Ahmad H, Raju SKR, Sangwan NS, Singh SK, Dwivedi AK, Wahajuddin M, Gayen JR (2020) Elucidation of plasma protein binding, blood partitioning, permeability, CYP phenotyping and CYP inhibition studies of Withanone using validated UPLC method: An active constituent of neuroprotective herb Ashwagandha. J Ethnopharmacol 270(113819):0378–8741. https://doi.org/10.1016/j.jep.2021.113819
Shukla S, Mehta A, John J, Mehta P, Vyas SP, Shukla S (2009) Immunomodulatory activities of the ethanolic extract of Caesalpinia bonducella seeds. J Ethnopharmacol. 125(2):252–256. https://doi.org/10.1016/j.jep.2009.07.002
Sharma RK, Cwiklinski K, Aalinkeel R, Reynolds JL, Sykes DE, Quaye E, Oh J, Mahajan SD, Schwartz SA (2017 Nov) Immunomodulatory activities of curcumin-stabilized silver nanoparticles: Efficacy as an antiretroviral therapeutic. Immunol Investig 46(8):833–846
Sharma V, Thakur M, Chauhan NS, Dixit VK (2010) Immunomodulatory activity of petroleum ether extract of Anacyclus pyrethrum. Pharm Biol 48(11):1247–1254
Sharma ML, Kaul A, Khajuria A, Singh S, Singh GB (1996) Immunomodulatory activity of boswellic acids (pentacyclic triterpene acids) from Boswellia serrata. Phytother Res 10:107–112
Sharma PV (1983). Charka Samhita. Ed. Chankhambhia orientalia, Vol. II, Varanasi
Sharma RK, Dash VB (1996) Agnivesha “Charak Samhita”, vol I, 1st edn. Chawkhamba Sanskrit Series Office, Varanasi
Shinde UA, Phadke AS, Nair AM, Mungantiwar AA, Dikshit VJ, Saraf MN (1999) Preliminary studies on the immunomodulatory activity of Cedrus deodara wood oil. Fitoterapia 70(4):333–339
Shuto T (2013) Regulation of expression, function, and inflammatory responses of innate immune receptor Toll-like receptor-2 (TLR2) during inflammatory responses against infection. Yasuaki zasshi 133(12):1401–1409
Srivastava A, Nigam AK, Mittal S, Mittal AK (2018) Role of aloin in the modulation of certain immune parameters in skin mucus of an Indian major carp, Labeo rohita. Fish Shellfish Immunol 73:252–261
Stites DP, Stobo JD, Fundenberg HH (1982) Basic and clinical immunology. Lange, Los Altos, CA
Sudha P, Asdaq SM, Dhamingi SS, Chandrakala GK (2010) Immunomodulatory activity of methanolic leaf extract of Moringa oleifera in animals. Indian J Physiol Pharmacol 54(2):133–140
Sunil MA, Sunitha VS, Ashitha A, Neethu S, Midhun SJ, Radhakrishnan EK, Jyothis M (2019 Jan) Catechin rich butanol fraction extracted from Acacia catechu L. (a thirst quencher) exhibits immunostimulatory potential. J Food Drug Anal 27(1):195–207. https://doi.org/10.1016/j.jfda.2018.06.010
Sunila ES, Kuttan G (2004) Immunomodulatory and antitumor activity of Piper longum Linn. and piperine. J Ethnopharmacol 90:339–346
Tawfik AF, Bishop SJ, Ayalp A, El-feraly FS (1990) Effects of artemesin, dihydroartemesin and arteether on immune responses of normal mice. Int J Immunopharmacol 12:385–389
Thakur M, Connellan P, Deseo MA, Morris C, Praznik W, Loeppert R, Dixit VK (2012) Characterization and in vitro immunomodulatory screening of fructo-oligosaccharides of Asparagus racemosus Willd. Int J Biol Macromol 50(1):77–81. https://doi.org/10.1016/j.ijbiomac.2011.09.027
Thakur M, Bhargava S, Dixit VK (2006) Immunomodulatory activity of chlorophytum borivilianum Sant.F. Evid Based Complement Alternat Med 4:419–423
Thejass P, Kuttan G (2007) Immunomodulatory activity of Sulforaphane, a naturally occurring isothiocyanate from broccoli (Brassica oleracea). Phytomedicine 14:538–545
Tiwari U, Rastogi B, Singh P, Saraf DK, Vyas SP (2004) Immunomodulatory effects of aqueous extract of Tridax procumbens in experimental animals. J Ethnopharmacol 92:113–119
Trivedi MK, Mondal SC, Gangwar M, Jana S (2017 Dec) Immunomodulatory potential of nanocurcumin-based formulation. Inflammopharmacology 25(6):609–619
Upadhyay SN, Dhawan S, Garg S, Talwar GP (1992) Immunomodulatory effect of neem (Azadirachta indica) oil. Int J Immunopharmacol 14:1187–1193
Vayalil PK, Kuttan G, Kuttan R (2002) Rasayanas: evidence for the concept of prevention of diseases. Am J Chin Med 30:155–171
Vázquez B, Avila G, Segura D, Escalante B (1996) Antiinflammatory activity of extracts from Aloe vera gel. J Ethnopharmacol. 55(1):69–75. https://doi.org/10.1016/s0378-8741(96)01476-6. PMID: 9121170
Wadekar RR, Agrawal SV, Teweri KM, Shinde RD, Mate S, Patil K (2008) Effect of Baliospermum montanum root extract on phagocytosis by human neutrophils. Int J Green Pharm 2:46–49
Wagner H (1986) Immunostimulants from higher plants. In: Hostettmann K, Lea PJ (eds) Biologically active natural products. Blackwell Scientific, Oxford, pp 127–128
Wagner H, Prokesh A (1985) Economic and medicinal plant research, vol 1. Academic Press, London, p 113
Wang W, Wang J, Dong SF, Liu CH, Italiani P, Sun SH, Xu J, Boraschi D, Ma SP, Qu D (2010) Immunomodulatory activity of andrographolide on macrophage activation and specific antibody response. Acta Pharmacol Sin 31(2):191–201
Xu Y, Chen A, Fry S, Barrow RA, Marshall RL, Mukkur TK (2007) Modulation of immune response in mice immunised with an inactivated Salmonella vaccine and gavaged with Andrographis paniculata extract or andrographolide. Int Immunopharmacol 7(4):515–523
Yousaf F, Shahid M, Riaz M, Atta A, Fatima H (2017) Immunomodulatory potential of Anacyclus pyrethrum (L.) and Mucuna pruriens (L.) In male albino rats. J Biol Regul Homeost Agents 31(2):425–429
Zhang C, Shao Z, Hu X, Chen Z, Li B, Jiang R, Bsoul N, Chen J, Xu C, Gao W (2020) Inhibition of PI3K/Akt/NF-ÎşB signaling by Aloin for ameliorating the progression of osteoarthritis: In vitro and in vivo studies. Int Immunopharmacol 89(Pt B):107079
Zhang XF, Wang HM, Song Y, Nie L, Wang L, Liu B, Shenb., P., and Liu, Y.. (2006) Isolation, structure elucidation, antioxidative and immunomodulatory properties of two novel dihydrocoumarins from Aloe vera. Bioorg Med Chem Lett 16:949–953
Zhang YH, Isobe K, Nagase F, Lwin T, Kato M, Hamaguchi M, Yokochi T, Nakashima I (1993) Glycyrrhizin as a promoter of the late signal transduction for interleukin-2 production by splenic lymphocytes. Immunology 79(4):528–534. PMID: 8406577; PMCID: PMC1421919
Zhao G, Kan J, Li Z, Chen Z (2005) Characterization and immunostimulatory activity of an (1-->6)-a-D-glucan from the root of Ipomoea batatas. Int Immunopharmacol 5:1436–1445
Zhao J, Wang J, Zhou M, Li M, Li M, Tan H (2019) Curcumin attenuates murine lupus via inhibiting NLRP3 inflammasome. Int Immunopharmacol 69:213–216
Zhong J, Wang F, Wang Z, Shen C, Zheng Y, Ma F, Zhu T, Chen L, Tang Q, Zhu J (2019) Aloin attenuates cognitive impairment and inflammation induced by d-galactose via down-regulating ERK, p38 and NF-κB signaling pathway. Int Immunopharmacol 72:48–54
Zhu T, Chen Z, Chen G, Wang D, Tang S, Deng H, Wang J, Li S, Lan J, Tong J, Li H, Deng X, Zhang W, Sun J, Tu Y, Luo W, Li C (2019) Mediat Inflamm 3(2019):4927430
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The authors would like to acknowledge DHR-ICMR project no. V.25011/286-HRD/2016-HR for financial assistance.
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Chauhan, N.S., Singh, M.R., Sharma, V., Yadav, N., Sangwan, N.S., Singh, D. (2022). Traditional Indian Knowledge of Immunity from Plants. In: Sangwan, N.S., Farag, M.A., Modolo, L.V. (eds) Plants and Phytomolecules for Immunomodulation. Springer, Singapore. https://doi.org/10.1007/978-981-16-8117-2_9
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