Abstract
Aging is an inevitable process accompanied by the degradation of organisms. The pathogenesis and progression of aging-related diseases such as diabetes, obesity, and neurodegenerative diseases are closely related to increased oxidative stress, dysfunction of mitochondrial biogenesis, activation of inflammation, and impairment of autophagy. The sirtuin family (SIRT1-7) mainly consists of antiaging molecules that function as nicotinamide adenine dinucleotide (NAD+) -dependent enzymes with deacetylase activity. Sirtuins have antioxidative and anti-inflammatory effects, and they improve mitochondrial function and restore impaired autophagy in multiple tissues and organs, including the brain, liver, kidney, and heart. A series of studies have demonstrated that interventions based on activating sirtuins, including calorie restriction, and drug interventions may confer protection against aging-related disorders. Sirtuins may become potential targets for the treatment of aging-related metabolic diseases in the future.
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Xu, J., Kitada, M. (2022). Sirtuins and Metabolic Health. In: Mori, N. (eds) Aging Mechanisms II . Springer, Singapore. https://doi.org/10.1007/978-981-16-7977-3_10
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